1.Giant scalp malignant peripheral nerve sheath tumor: one case report.
Da-wei CHEN ; Wei-hong GU ; Shuang-lin FU
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2011;46(12):1047-1048
Head and Neck Neoplasms
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pathology
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Humans
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Male
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Middle Aged
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Neurilemmoma
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pathology
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Neurofibroma
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pathology
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Scalp
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pathology
2.Disseminated histoplasmosis in a boy presenting fever and jaundice as first manifestations.
Liang CHENG ; Chun-Yuan CHEN ; Yong-Hong GU
Chinese Journal of Contemporary Pediatrics 2010;12(11):927-928
Child, Preschool
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Fever
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etiology
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Histoplasmosis
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complications
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diagnosis
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pathology
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Humans
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Jaundice
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etiology
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Male
3.Viral nephropathy.
Gu-ming ZOU ; Yi-pu CHEN ; Hong-rui DONG
Chinese Journal of Pathology 2010;39(2):130-132
Adenovirus Infections, Human
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pathology
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virology
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Glomerulonephritis, Membranous
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pathology
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virology
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HIV Infections
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pathology
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virology
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Hepatitis B
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pathology
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virology
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Hepatitis C
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pathology
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virology
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Herpes Zoster
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pathology
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virology
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Herpesvirus 3, Human
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isolation & purification
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Humans
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Kidney
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pathology
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virology
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Kidney Diseases
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pathology
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virology
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Nephritis, Interstitial
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pathology
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virology
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Parvoviridae Infections
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pathology
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virology
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Parvovirus B19, Human
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isolation & purification
4.Malignant atrophic papulosis: report of a case.
Qian CHEN ; Yong-hong GU ; Zhan-san SU ; Qiong ZOU
Chinese Journal of Pathology 2009;38(12):845-846
Adult
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Female
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Humans
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Intestinal Perforation
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etiology
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pathology
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surgery
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Malignant Atrophic Papulosis
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complications
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pathology
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surgery
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Young Adult
5.Behavioral characteristics of children with tic disorder at different clinic conditions
Chengyao LI ; Hong CHEN ; Jinping JL ; Zhang LIU ; Hongli GU
Clinical Medicine of China 2011;27(12):1334-1337
Objective To assess the behavior of children with tic disorder (TD),and to analyze the behavioral characteristics among children with TD at different clinic conditions.Methods Sixty-three children with TD were evaluated with Child behavior checklist (CBCL).ANOVA and t-test were used to analyze the difference in the total and individual scores of CBCL in the children classified according to the different clinical types,the severity of TD,and comorbid attention-deficit hyperactivity disorder(ADHD).Results There were no significant differences among the total and individual scores of CBCL in the patients of the different clinic types( P < 0.05 ) ;the scores of body complain in the patients in moderate to severe conditions (4.15 ± 2.34) were higher than that of those in mild condition ( 2.68 ± 2.22 ) ( t =- 2.540,P =0.014) ; the scores of attention problem (9.94 ± 3.57 ),disciplinary offence ( 3.94 ± 3.06 ),aggressive behavior ( 15.39 ± 5.12 ),exportoriented behavior problems ( 13.98 ± 7.34)and behavior problem (47.89 ± 17.51 )in TD comorbid ADHD were higher than in simple TD group ( 7.31 ± 3.34,2.44 ± 2.22,7.24 ± 4.93,9.78 ± 6.55,37.07 ± 17.98 ) ( t =- 2.774,- 2.166,- 1.930,- 1.956,- 2.174,P =0.007,0.034,0.048,0.04 1,0.034 ).Conclusion Children with TD at different clinical conditions have varied behavioral problems and behavioral characteristics,while comorbid ADHD is the most significant factor to affect TD patient's behaviors.
6.Gene therapy with human vascular endothelial growth factor in prevention of restenosis after angioplasty
Shaoping CHEN ; Hong GU ; Yongchun WANG ; Yongwen QIN ; Guoyuan ZHANG
Academic Journal of Second Military Medical University 2001;22(5):443-446
Objective: To investigate the effect of human vascular endothelial growth factor on restenosis after angioplasty. Methods: A rabbit model of injured carotid artery was established using percutaneous transluminal angioplasty. The pcDNA3/hVEGF165(500 μg,n=12) and pcDNA3 (500 μg,n=12) were separately transfected into injured arterial wall with 30 min incubation. The carotid artery was imaged by arotic angiography at the end of week 2 and week 4. Pathology analysis and Northern blot analysis were performed for harvested injured artery segment. Results: Arotic angiography showed carotid artery diameter narrowness were obviously lessened at week 2 and week 4 in experimental group than that in control group; H-E stains showed lumina narrow ratio were obviously reduced at week 2 and week 4 in experimental group than that in control group[(9.58±1.35)% vs (31.72±1.72)%;(18.09±2.93)% vs (44.05±3.28)%, P<0.01 ]; By Northern blot analysis, the expression of hVEGF165mRNA in experimental group were upregulated than in contol group. Conclusion: pcDNA3/hVEGF165 can be transfected into smooth muscle cell and continue to secret bioactivity protein at least for 4 weeks; it can accelerate reendothelialization and prevent restenosis.
7.The relationship between inhibition of hepatitis B virus replication induced by tumor-necrosis factor α and the up-regulated proprotein convertases
Yan CHEN ; Hong SHI ; Lin GU ; Xiaomou PENG
Chinese Journal of Infectious Diseases 2014;32(2):85-88
Objective To investigate the effects of tumor-necrosis factor α (TNF-α) on the expressions of proprotein convertases (PC) and its relationship with the inhibition of hepatitis B virus (HBV) replication.Methods HepG2.2.15 cells cultured routinely were exposed to 20 μg/L recombinant TNF-α and/or 20 μmol/L PC inhibitor (DEC) for 18 h.Then Followed cells werecollected and cell total RNA and HBV DNA were extracted.PC mRNA and core-associated HBV DNA were measured using real-time polymerase chain reaction (PCR) techniques.Measurement data was compared using t-test.Results When PC mRNA expressions in the blank group was as to 1,the expressions of PC1/3、PC2、furin、PC4 、PC5/6 、PACE4 and PC7/8 mRNA in HepG2.2.15 cells treated with 20μg/L TNF-α treatment for 18 h were all up-regulated,which were 3.3±0.7、79.3±3.3、77.5±1.3、19.2±3.1、1.3±0.1、1.4± 0.2、274.8± 7.1,respectively (all P<0.05).Treatment of 20 μg/L recombinant TNF-α for 18 h significantly reduced core-associated HBV DNA compared with blank gourp (0.21∶1,t =8.79,P =0.002),while 20 μmol/L DEC significantly up-regulated core-associated HBV DNA (3.84∶ 1,t=7.67,P=0.004).Moreover,core-associated HBV DNA in group of DEC and TNF-α treatment was significantly higher than group of TNF-α treatment (0.31∶0.21,t=10.49,P=0.007).Conclusion Up-regulated PC mRNA expression induced by TNF-α is significantly associated with the inhibition of HBV replication.
8.Analysis of Clinical Symptoms and Blood Lipid Components in Simple Obesity Children
A-YI-GU-LI ; yong-hong, CHEN ; jun-bao, DU
Journal of Applied Clinical Pediatrics 2004;0(07):-
Objective To analyze blood lipid components in simple obesity children and to explore the effects of obesity in the lipid metabolism and its clinical significance.Methods A total of 90 children,including 50 simple obesity children(obesity group)and 40 normal children(control group),were enrolled in this study.The age ranged from 2.5 to 16.0 years.Their blood lipid profiles of all the children were analyzed.The blood lipid profiles were examined by biochemical analysis,including triglyeride(TG),total cholesterol(TC),low density lipoprotein(LDL) and high density lipoprotein(HDL),and the livers of all the children were analyzed.The blood lipid profiles were examined by ultrasonograph.Results 1.There were no significant differences in age and height in obesity group and control group,but there were significant differences in body mass index(BMI) and blood pressure(P0.05),which had no statistical meaning.3.Liver ultra sonogram showed that 18 cases had fatty liver(36%) in simple obesity children.Conclusions Metabolic disorder of blood lipid is present in simple obesity children,who have a tendency to get fatty liver.LDL is markedly elevated in obesity group.Arteriosclerotic cardiovascular disease should be prevented at earlier period of childhood.
9.Stability assessment of neonatal parenteral nutrition solutions with various amino acid concentrations
Yingfen GU ; Li HONG ; Minling CHEN ; Shiying HUANG ; Juan WU
Chinese Journal of Clinical Nutrition 2017;25(2):72-77
Objective To explore the influence of various concentrations of amino acid on the stability of neonatal parenteral nutrition solutions .Methods Five formulations were designed with 5 different amino acid concentrations containing the same components .The final amino acid concentrations of admixtures were 0%, 1%, 2%, 3%, and 3.5%, respectively .The appearance , pH, and osmolality were observed or meas-ured after preparation (0 hour) and at 12, 24, 48 and 72 hours after preparation.The average size and the size distribution of the lipid globules were also evaluated by laser nanometer particle size analyzer .Results There was no observable alteration in color , phase separation , precipitate , and flocculation in any admixture at any of the observation time points.The mean pH values for all groups were between (5.49 ±0.01) to (6.19 ±0.01) within 72 hours.The mean osmolalities for all groups were between (774 ±3) to (1106 ±13) mOsm/kg.The mean diameters of lipid globules for all groups were between (280.6 ±0.7 ) mm to (332.2 ±2.0 ) nm.The mean polydispersity for all groups were between (0.200 ±0.011) to (0.245 ±0.012).The enrichment of ami-no acid concentration was linked to lower pH ( P=0.000 ) , higher osmolality ( P=0.000 ) and larger average lipid globules size ( P=0.000 ) .However , there was no distinct linear dependence between amino acid concen -tration and polydispersity value ( P=0.628 ) .Conclusion After 72 hours of storage at room temperature , the appearance, pH, osmolality, and the average lipid globules diameter of the parenteral nutrition solutions are within the safe range when the amino acid is not contained or the concentrations are no more than 3.5%.
10.Analysis of malignant tumor incidence and mortality surveillance in Jiaxing from 2010 to 2015
Jianwei WANG ; Xia HONG ; Wenyan CHEN ; Jun MA ; Weiling GU
Chinese Journal of Geriatrics 2017;36(9):1019-1023
Objective To analyze the changes and characteristics of cancer incidence and mortality among Jiaxing residents in the past 6 years,and to provide evidence for the prevention and control of cancer incidence and mortality.Methods Registered malignant tumor data from the Zhejiang Chronic Disease Information Monitoring and Management System were collected and analyzed based on the International Statistical Classification of Diseases (ICD-10).The statistical indexes used for analyses included crude incidence,standardized incidence,crude ortality,standardized mortality,potential years of life lost (PYLL),average years of life lost (AYLL),rate of potential years of life (PYLL‰) and so on.Results From 2010 to 2015,the crude incidence,the standardized incidence,the crude mortality,and the standardized mortality were 342.52/105,240.89/105,194.71/105 and 126.27/105,respectively.The crude incidence and mortality for males were both higher than those for females(378.44/105 vs.307.49/105,x2=763.06,P<0.01;255.31/105vs.135.62/105,x2-3 814.11,P<0.01).The PYLL,AYLL and PYLL‰ of residents in Jiaxing were 248,307 years,6.16 years and 12.00‰,respectively.The PYLL‰for males was significantly higher than that for females(x2=37073.85,P<0.01).The AYLL for females was 6.50 years,higher than that for males(5.98 years)(t =125.15,P<0.01).The incidence of malignant tumors increased with age,especially in the older than 40 age group,with the older than 80 age group showing the highest rate at 1 779.01/105 (x2 =38 840 907,P < 0.01).Rates for Lung cancer (70.59/105),colorectal cancer (39.86/105),liver cancer (29.14/105),breast cancer(26.73/105) and stomach cancer (26.00/105) were the most common malignant tumors in Jiaxing.Conclusions The morbidity and mortality of malignant tumors are showing signs of rising and the incidences of lung cancer and gastrointestinal cancer are particularly pronounced in Jiaxing.In consequence,measures for the prevention and control of malignant tumors should be developed with clearly defined objectives and research on the pathogenesis of malignant tumors should be stepped upto reduce the incidence and mortality of malignant tumors.