ve To investigate the effects of different doses of diltiazem alone or combination with isoflurane on stunned isolated rat heart. Methods Adult male Wistar rats weighing 325-350g were anesthetized with intraabdominal pentobarbital sodium 60mg?kg-1. Heparin 200IU was injected into femoral vein. Chest was then opened and heart was removed and connected to Langendorff preparation. The isolated rat heart was perfused at 100cm H2O with Krebs-Hensleit buffer(KHB) balanced with 95%O2 and 5%CO2 at 37℃ and electrically paced at 300 bpm. Global myocardial ischemia was produced by suspension of perfusion. The isolated rat heart underwent 20 min ischemia followed by 30min reperfusion. 40 rat hearts were randomly allocated to one of 5 groups of eight each, group Ⅰ received no treatment and served as control; group Ⅱ: the isolated heart was perfused with 0.1/?mol?L-1 diltiazem for 10 min before the onset of ischemia; group Ⅲ: with 0.5?mol?L-1 diltiazem; group Ⅳ: with 0. 1?mol?L-1 diltiazem + 1.5MAC isoflurane; group Ⅴ: with 0.5?mol?L-1 diltiazem + 1.5MAC isoflurane. Left ventricle developed pressure(DP) was measured from a fluid-filled Latex balloon placed in left ventricle. The volume of the fluid in the balloon was regulated to maintain the left ventricle end-diastolic pressure at 5-8 mm Hg. Peak systolic pressure(PSP), end-diastolic pressure(EDP) and developed pressure(DP) were measured after the isolated heart was stabilized for 10min (baseline value) and 5, 10, 15, 20, 25, 30min after reperfusion. Maximum intraventricular pressure was measured during ischemia when the isolated heart was not paced and at a stand still. Results There was no significant difference in DP, EDP, + dp/dtmax and - dp/dtmin after the isolated hearts were stabilized for 10min, before ischemia among the five groups. Perfusion with 0.1?mol?L-1 diltiazem did not affect DP significantly but 0.5?mol?L-1 diltiazem significantly decreased DP (P

0.05).Conclusion The therapeutic mechanism of AEP of Chinese herbal medicine for asthma may be related with the inhibition of EOS infiltration,the decrease of peripheral IL-4 content and the increase of IFN-?.

OBJECTIVE:To investigate the effects of clopidogrel plus atorvastatin on ischemic cardiovascular diseases and to explore the clinical significance of drug interactions.METHODS:Literatures were retreived from EMBase,PubMed,Cochrane Library and CNKI with clopidogrel,atorvastatin,clinical trial as

Objective To investigate the clinical efficacy of fire needle puncture combining with chinese herbal medicine for treating sciatica. Methods Sciatica outpatients were randomly allocated to a Fire needle puncture plus chinese herbal medicine of 37 cases( treatment group) and a western medication group of 32cases( comparison group). In the former, fire needle puncture and chinese herbal medicine was performed for two or three treatment courses; in the latter, only western medication was given during the same period. Results A comparison of the curative effects at one day after the treatment showed that the marked efficacy rate and effective rate in the treatment group were 78.4% and 97.20% respectively, and in the comparison group was 43.8% and 84.4%. The comparison of the curative effects between the two groups showed that all these patients got better in the treatment group than in the comparison groups and there was very significant difference ( P

OBJECTIVE To explore optimal change dressing of the incision of trachea.METHODS Seventy-eight patients were randomly and equally divided into the traditional group and test group.In traditional group,after dressings change with conventional disinfection,the sterile gauze was cut into "E" shape and overlapping covered on the incision of trachea around the trachea cannula from top to bottom and fixed with adhensive plaster.In test group,after dressings change with conventional disinfection,the special sterile drainage was fixed and smoothed around the trachea cannula from left to right(or from right to left).RESULTS In test group,skin incision colonies of patients were significantly lower than that in traditional group(P

Child ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; Phytotherapy ; Pneumonia, Mycoplasma ; diagnosis ; drug therapy

Objective To evaluate the value of percutaneous endoscopic gastrostomy (PEG) in the treatment of amyotrophic lateral sclerosis (ALS) patients with dysphagia. Method Sixty-five ALS patients underwent PEG from April 2005 to July 2010 were analysed retrospectively. Results All the 65 patients underwent PEG,and 2 patients failed because of dyspnea. Totally 63 patients were intubated successfully,the successful rate was 96.9%(63/65). The operation time was 8-17 min. Two patients had local infection.After 3 months, the body mass index was increased from (18.3 ± 1.0) kg/m2 to (19.7 ± 1.2) kg/m2(t = 15.8,P ＜ 0.01), without peritonitis, migration of the gastrostomy tube and other complications. Conclusions PEG is a safe method with a low complication for ALS patients to get enteral nutrition. Dyspnea is the main reason of failure.

Objective To compare the effect of acupuncture and swallowing training on dysphagia in recove-ring stroke patients. Methods One hundred and thirty-two subacute stroke inpatients,73 males and 59 females,with a mean age of(67.9±9.0)years,26 cerebral hemorrhage patients and 106 cerebral infarct patients,participa-ted in the study.The patients were divided into a swallowing training group(ST,n=53)treated with thermal-tactile stimulation,deglutition exercises and food swallowing training;an acupuncture group(AP,n=48) treated with acu-puncture at the Fengchi(GB20),Lianquan(RN23),Bailao(EX-HN15),Jinjing(EX-HN12) and Yuye (EX-HN13)acupoints;and a control group(CG,n=31).The interventions were administered once a day,6 times a week.Before and after treatment,the patients were evaluated with a water-swallowing test and the"Any Two"test,and the arterial oxygen saturation(SpO_2) was monitored by pulse oximetry. Results The ST and AP groups showed significant improvement in water-swallowing and on the"Any Two"test after the treatment regimen,and were significantly better than the control group.There was no significant difference between the ST and AP groups.The average decrease in SpO_2 during water-swallowing was under 2%.After treatment,the baseline SpO_2 and post-water-swallowing SpO_2 of the ST group were significantly higher than those of the control group.The post-water-swallowing SpO_2 of the AP group was also significantly higher than that of the control group. Conclusions Acupuncture and swallowing training have similar effects in treating dysphagic stroke patients.Swallowing function and misaspiration cannot be predicted based on decreases in SpO_2.

Objective To investignte the effects of ambroxol on lung injury in children undergoing cardiac surgery with cardiopulmonary bypass (CPB).Methods Thirty-six ASA Ⅱ or Ⅲ children of both sexes aged≤8 yr,weighing≤25 kg undergoing repair of ventricular septal defect (VSD) under CPB were randomly divided into 3 groups (n=12 each):I control group (C);II low dose ambroxol group (2.25 mg/kg) (A,) and III moderate dose ambroxol group (4.50 mg/kg) (A2).Ambrexol was diluted with normal saline 10 ml and infused slowly after skin incision in group A1 and A2.In group C equal volume of normal saline(10 ml) was infused instead of ambroxol.Blood samples were taken from radial artery before skin incision,at 20 rain of CPB,20 rain after aortic unclamping,2 h and 6 h after temtination of CPB and 12 h after operation for determination of plasma MDA concentration and SOD activity and blood gas analysis.Respiratory index (RI) and pulmonary compliance (CL)were calculated.Results The plasma MDA concentration and RI were significantly lower while plasma SOD activity was significantly higher in group A2 than in group C and A1·CL was significantly higher in group A2 than in group C.Conclusion Ambroxol 4.50 mg/kg can attenuate lung injury in children undergoing cardiac surgery with CPB by decreasing lipid peroxidation.