1.Analysis of Drug Resistance of Clinical Pathogenic Bacteria in Our Hospital in 2006
China Pharmacy 2005;0(20):-
OBJECTIVE: To analyze the drug resistance of common pathogenic bacteria in our hospital.METHODS: A retrospective analysis was conducted on the pathogenic bacteria clinically isolated in 2006.RESULTS: Of the total 1 723 clinical isolated strains,77.9% were gram negative bacteria.Leading the first 6 places on the list of common clinical pathogenic bacteria were Escherichia coli,klebsiella pneumoniae,pseudomonas aeruginosa,acinetobacter baumannii,enterobacter cloacae,and staphylococcus aureus.CONCLUSION: Drug resistance is a very severe problem faced by the clinic.It is urgent to carry out monitoring of bacterial resistance and rational use of antibacterials.
2.Expression and significance of eotaxin in nasal secretions
Chongqing Medicine 2014;(3):288-289,292
Objective To discuss the expression and significance of eotaxin in the nasal secretions of the patients with nasal pol-yps .Methods The nasal secretion samples were collected from 40 patients including 15 cases of nasal polyps ,15 cases of chronic si-nusitis and 10 cases of nasal septum deviation .The enzyme-linked immunosorbent assay(ELISA) was adopted to detect the concen-tration of eotaxin .Results The average concentration of eotaxin was (468 .82 ± 440 .64)pg/mL in nasal polyps ,(443 .85 ± 334 .68) pg/mL in chronic sinusitis and (149 .23 ± 49 .01)pg/mL in nasal septum deviation .The eotaxin concentrations in the nasal polyps group and the chronic sinusitis group were higher than those in the nasal septum deviation group ,the difference was statistically significant(P<0 .05) .Conclusion The eotaxin concentration in the nasal secretions of the patients with nasal polyps is significantly increaseed ,which might be concluded that eotaxin may play an important role in the occurrence and development process of nasal polyps .
3.Organ-sparing surgery in andrology.
National Journal of Andrology 2015;21(12):1059-1063
Penile and testicular tumors, especially those of the malignant nature, usually require radical excision, which alters the organ image, affects sexual and urinary functions, and consequently undermines the self-confidence and quality of life of the patient. Recent studies show that organ-sparing surgery can be an alternative to radical excision for superficial tumors and small masses. Penis-sparing surgery (PSS) has been indicated for superficial penile cancer, such as Tis and T1a lesions, and testis-sparing surgery (TSS) is feasible for benign small bilateral or solitary testicular masses (TIN). Long-term follow-ups after PSS or TSS show that the patients may retain a satisfactory appearance of the organ as well as desirable sexual and reproductive functions.
Andrology
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methods
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Humans
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Libido
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Male
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Organ Sparing Treatments
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methods
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Patient Satisfaction
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Penile Neoplasms
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surgery
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Quality of Life
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Self Concept
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Testicular Neoplasms
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surgery
6.Research on the clinical efficacy and safety of atropine with short covering for amblyopia in children
International Eye Science 2016;16(8):1528-1530
Abstract?AIM: To discuss clinical efficacy and safety of 10g/L atropine with short covering for children with amblyopia.?METHODS: Eighty -eight children ( 88 eyes ) with amblyopia, staying in hospital from February 2011 to February 2014 for treatment, were divided into control group ( n =44 ) and observation group ( n =44 ) . The control group only given short covering therapy was observed.Observation group was given 10g/L atropine treatment besides covering.Clinical efficacy, treatment compliance, visual acuity, corrected spherical degree of amblyopia eye and adverse events were observed and compared.?RESULTS:1) After treatment, total effective rate of the observation group was 95% ( 42/44 ) , significantly higher than that of control group ( 80%, 35/44, P<0.05 ); 2 ) excellent compliance rate of the observation group was 95% ( 42/44 ) , significantly higher than that of control group (82%, 36/44, P<0.05);3) visual acuity of the two groups when the disease was first diagnosed was not significantly different (P>0.05), but increased number of lines of vision and corrected spherical degree of amblyopia eye in the observation group were significantly higher (P<0.05);4) in the observation group total rate of adverse events was 9% ( 4/44 ) , significantly lower than that in the control group (23%, 10/44, P<0.05).?CONCLUSION: The combined therapy, 1% atropine with short covering, is effective and safe for amblyopia in children.
8.Research advances of miR-126 and ophthalmic diseases
Ning-Ning, GAO ; Fan-Qian, SONG ; Hong-Yan, GE
International Eye Science 2017;17(6):1066-1068
Up to now, a variety of microRNAs have been found in a number of studies, that specifically expressed in retinal neuroepithelial, lens, cornea and retinal pigment epithelium, in which miR-126 plays a certain role in the proliferation of tumor cells, the development of thymus lymphocytes and cardiovascular diseases.Some researches show that miR-126 has certain correlations with the formation of corneal neovascularization, the development of diabetic retinopathy, and the immune system related eye disease.In this paper, the current miR-126 in the role of eye disease mechanism and research progress were reviewed.
9.Discuss The Strategy of the Development of Scientific Research Secretary in Clinical Department
Xiao CAI ; Ning NING ; Hong ZHI ; Hao GUO
Chinese Journal of Medical Science Research Management 2016;29(3):216-217,221
Scientific research management has become a crucial work in each hospital.The quality of scientific research management directly affects the level of scientific research development.Scientific research secretaries act as the direct participants and grassroots community of scientific research management,whose strengths and weaknesses of development related to the level of scientific research management directly.This study put forward several countermeasures on the barriers of hospital scientific research secretaries development,aiming to promote the development of hospital's scientific research and discipline construction.
10.Association of depression with dietary fatty acids and the progress of mechanism research
Ning-ning ZHANG ; Zhen-zhen WANG ; Nai-hong CHEN
Acta Pharmaceutica Sinica 2021;56(4):906-912
Depression is one of the diseases with the highest disability rate in the world. A large number of studies have shown that the intake of unsaturated fatty acids can deal with depression while chronic overconsumption of saturated fatty acids is a risk factor for depression. It was suggested that the mechanism of saturated fatty acids inducing depression is related to the following four aspects: regulating the function which links to depression in whole brain and specific brain regions, including the hippocampus, the hypothalamic-pituitary-adrenal axis, the striatum, and the prefrontal cortex; stimulating the secretion of inflammatory factors; affecting the balance and function of metabolic regulatory hormones, including leptin, adiponectin, glucocorticoid, and insulin; inducing the disturbance of intestinal flora. This article reviews the relationship between dietary fatty acids and depression, and the possible mechanisms by which saturated fatty acids induce depression from the four aspects mentioned above.