Objective:To study the clinical effect of blood purification and sustained glucocorticoid therapy on severe pancreatitis with respiratory distress syndrome,for providing clinical reference for such concomitant diseases.Methods:A total of 132 patients from April 2012 to June 2014in our hospital with severe pancreatitis and respiratory distress syndrome were studied,they were randomly divided into two groups,patients in the two groups were given conventional anti-infective,gastrointestinal decompression,rehydration therapy and other infrastructure,the control group were treated with continuous blood purification treatment,the observation group were treated with continuous blood purification and high-dose dexamethasone,the clinical symptoms,laboratory indicator in time,the levels of inflammatory cytokines,the APACHE Ⅱ scores and MODS scores and survival were compared.Results:The time of abdominal distention disappeared,blood amylase,urine amylase and pancreatic edema improvement in observation group was significantly improved than the control (P＜0.05);when compared with before,the CRP,IL-6,IL-8 and TNF-α of two groups were significantly decreased,and the index in observation group decreased more significantly,the difference was statistically significant (P＜0.05);when compared with before,the score of APACHE Ⅱ and MODS were significantly lower than control,the difference was statistically significant(P＜0.05);The final survival rate in observation group was 90.8％,which significantly higher than 61.5％ in control,the difference was statistically significant(P＜0.05).Conclusion:The effect of continuous blood purification combined with glucocorticoids (eg dexamethasone) in patients with severe pancreatitis and respiratory distress syndrome is remarkable,the clinical symptoms can significantly improved,the levels of inflammatory factors,effective recovery laboratory indicators,APACHE Ⅱ score and MODS score were decreased,the survival was higher,it was worthy of clinical use.

The study was carried out in Thanh Tri district on 109 infants aged 0-3 months who received a dose of 0.05mg of intradermal BCG vaccine. The result showed that: the tuberculin conversion rate in infants was satisfactory (96.33%), the rate of non-suppurative adenitis was 3.67% and the rate of suppurative adenitis was 0.917%.
Immune System ; BCG Vaccine ; infant

The study was conducted in 796 newborns and infants aged 1-90 days. The newborns were randomly divided into three groups receiving different doses (0.05mg and 0.025mg) of Nha Trang BCG vaccine and 0.05mg of Pasteur BCG vaccine, intradermally. The results showed that the tuberculin conversion was satisfactory in both groups (receiving 0.05mg and 0.025mg dose of Nha Trang BCG vaccine), while the percentage of suppurative adenitis was found significantly higher in the group receiving 0.05mg BCG vaccine
BCG Vaccine ; Pharmaceutical Preparations ; child ; Infant, Newborn

Objective To probe into clinical application value of tetramethylpyrazine injection as an adjuvant of 1,6-diphosphate in the treatment of neonatal hypoxic-ischemic encephalopathy.Methods From January 2012 to December 2012,98 neonatal hypoxic-ischemic encephalopathy children patients were selected in the Second Affiliated Hospital of Shenyang Medical College.The children patients were divided into observation group and control group randomly.There were 49 cases in each group.Both two groups adopted 1 ,6 diphosphate - fructose,and the observation group adopted ligustrazine injection on the basis of control group.The clinical treatment and prognosis of the children patients in two groups were compared and analyzed.Results The rates of significant efficiency and total efficiency were 67.35%and 93.88%in observation group,which were higher than those in control group (51.02%,71.43%),and there were statistically significant (P <0.05 );compared with control group,the NBNA scores of observation group were improved significantly after 3rd,7th and 14th days treatment,and there were statistically significant (P<0.05);compared with control group,the ratio of cerebral palsy,epilepsy,mental retardation and death in observation group showed different degree of reduction,but there were no statistically significant.Conclusion The effect of tetramethylpyrazine injection adjuvant 1 ,6-diphosphate in treatment of neonatal hypoxic-ischemic encephalopathy was effective and significant.It has positive role in promoting the improvement and upgrading of the clinical efficacy and prognosis.

The aim of this review is to evaluate the recent advances in chemotherapy for upper gastrointestinal tumors (esophagus,stomach,pancreas,liver).The role of both the neoadjuvant,adjuvant and palliative chemotherapy regimens, efficacy and side effects will be discussed,as well as its future development.

Background and purpose:The mutation of BRCA1 gene is widely acknowledged to be related to the incidence of triple-negative breast cancer (TNBC). The aim of this study was to investigate the association between TNBC and single nucleotide polymorphisms (SNPs) of BRCA1-associated genes. Methods:This study investigated the associations between the BRCA1-A complex genes and risk of developing TNBC in a case-control study of Chinese Han Women population including 414 patients with TNBC and 354 cancer-free controls diagnosed in the Fudan University Shanghai Cancer Center during 2008-2011. This study also detected 37 common variants in Abraxas, BRE, Rap80, NBA1 and BRCC36 genes encoding the BRCA1-A complex and evaluated their genetic susceptibility to the risk of TNBC. An additional cohort with 652 other types of breast cancer (non-TNBC) cases and 890 controls were used to investigate the associations between TNBC-speciifc SNPs genotype and non-TNBCs susceptibility. Results:This study found that rs7250266 in the promoter region of NBA1 confers a decreased risk to TNBC (P<0.01). Compared with CC genotype, women with the GC genotype (OR=0.70, 95%CI:0.51-0.97) and GG genotype (OR=0.48, 95%CI:0.21-1.07) had a lower risk of developing TNBC (P=0.03). In addition, the haplotypes containing two polymorphisms rs7250266 and rs2278256 were associated with a lower chance of TNBC development. In the second part of the study, the result showed that there was no difference in rs7250266 expression between non-TNBC and normal people (0.19 vs 0.18, P=0.85).Conclusion:Genetic variants in NBA1 may be an important genetic determinant of TNBC susceptibility in Chinese women.

Objective To explore the effect of acupuncture combined with rehabilitation training on unilateral spatial neglect (USN).Methods One hundred stroke patients with USN were randomly divided into a treatment group (n=50) and a control group (n=50).Both groups were treated with routine rehabilitation training for 4 weeks,while the treatment group was additionally treated with acupuncture.Before and after the treatment,the degree of USN was evaluated in both groups along with the Fugl-Meyer assessment,the modified Barthel index and the incidence of shoulder pain.Results No significant differences were found between the 2 groups in any of the measurements before the treatment.After the treatment the incidence of shoulder pain in the treatment group was significantly lower than that in the control group.All the other measurements were significantly higher in the treatment group than in the control group.Conclusion Acupuncture combined with rehabilitation training can significantly improve the symptoms of unilateral spatial neglect,improve motor function in a hemiplegic limb and improve performance in the activities of daily living.

The changes of lipid peroxidation in the ischemic (renal artery occlusion for 75 min) and ischemie/reperfusion (renal artery occlusion 60 min plus 15 min reflow) kidney was studied in 19 male SD rats. The results showed that malondialdehydc of renal cortex and medulla was increased, but in both groups SOD and GSH-Px were not changed significantly. Activity of xanthine oxidase activity in the ischemic/reperfusion kidney were increased as compared with normal. These results suggest that lipid pcroxidation was involved in the ischemic and ischemic/reperfusion renal injury, and xanthine-xanthine oxidase might be one of the major sources of oxygen free radical when oxygen supply to ischemic kidney was restored.

Objective To explore the clinical significance of gastric hyperplastic polyp pits under magnifying endoscopy. Methods Summary confirmed by magnifying endoscopy and pathological examination gastric hyperplastic po]yp's performance of magnifying endoscopy,Hp positive and the results of pathology during February 2004 to De-cember 2006. Results 55 patients found 116 gastric polyp,41.4% (48/116) with type A,26.7% (31/116) with type B,19. 8% (23/116) with type C,8. 6% (10/116) with type D,2. 6% (3/116) with type E,one case gastric pits blurred(type F) 0. 9% (1/116). 4 cases with type E and type F found moderate-severe atypical hyperplasia. Conclu-sion Gastric hyperplastic polyp pits with type E and type F ,their results of pathology to display atypical hyperplasia.

Background and purpose: Paget's disease (PD) of the breast is a rare disease. The survival of PD was reported to be related to the characteristics of the underlying carcinoma. This study aimed to investigate the char-acteristics and survival of PD patients with underlying invasive breast carcinoma (IBC). Methods: Fifty-four patients diagnosed with PD and an associated IBC in Fudan University Shanghai Cancer Center from 2002 to 2007 were re-cruited in this study as study group. Since most PD overexpress HER-2, 72 patients with HER-2-overexpressing breast cancer were randomly recruited as control group. This study compared survival between these two groups. Results:Twenty-five (46.3％) patients in study group had no clinical manifestation of PD and were diagnosed unexpectedly by a histologic examination. Thirty-five (64.8％) patients in study group had tumors larger than 2 cm, twenty-six(48.1％) patients in study group had chance of axillary lymph node involvement. Compared with control group, patients in study group tended to have more events (5-year relapse-free survival: 76.4％ vs 48.5％, P<0.01). In the control group, most events occurred in the first 3 years after operation, while recurrence might happen all along in the 5 years after opera-tion in study group. Patients in study group also had a poorer overall survival than in control group (61.0％ vs 80.6％, P=0.01). Conclusion: Patients with Paget's disease and underlying invasive breast cancer tend to have poorer survival than those with HER-2-overexpressing breast cancer.