The Purpose of this paper is to give consideration to the Ttought Underliying the clinical practice of Moxa treatment before Meiji period.
I investigated the literature on the therapy from a point of “technological thought”.
My study reveals that in Japan they had atlached more and more importance to the “Ying-yang and Wu-xingTheory” (_??__??__??__??__??_), that was not originally emphasized in China.

The authors investigated the efficacy, safety and usefulness of the Kampo extract Shoseiryu-to (TJ-19) in the treatment of adult bronchial asthma. The multi-center study used the same methods presently in use in Japan for clinical evaluation of Western drugs and included a total of 69 patients in an open trial.
After long-term (4-8 weeks) administration of the Kampo formula in conjunction with conventional bronchial dilators, a significant improvement was seen in the frequency score, clinical score and asthma score. Significant improvement was observed in individual symptoms such as phlegm viscosity and amount, daily life, sleep, sneezing and nasal discharge. Overall, the results indicated marked improvement in 13 patients (18.8%), moderate improvement in 23 patients (33.3%) and slight improvement in 19 patients (27.5%). Thus, the authors obtained the favorable results of moderate or better improvement in 52.2% and slight or better improvement in 79.9% of the patients. We observed almost no abnormal findings in laboratory examinations due to the drugs. Side effects developed only in a few patients in the form of a slight cough. Symptoms of nasal allergy improved most frequently according to the impressions of the physicians in charge. Recently, combination therapy using various Kampo extracts has increased in Japan in order to improve treatment quality.

A 71-year-old woman presented with a 2-month history of progressive exophthalmos. Magnetic resonance imaging revealed a tumor occupying the right frontal sinus that compressed the right orbit and eye ball. The tumor was resected through a right frontal craniotomy. The pathologic diagnosis was leiomyoma and similar to the histologic diagnosis of a uterine leiomyoma resected 4 years earlier. We suggest that this rare sinonasal leiomyoma was a benign metastasizing leiomyoma from the uterus to the nasal sinus.

For the purpose of protecting the rights of Lentinula edodes breeders, we developed a new simple sequence repeat (SSR) marker set consisting only of genetically independent tetranucleotide or longer core motifs. Using available genome sequences for five L. edodes strains, we designed primers for 13 SSR markers that amplified polymorphic sequences in 20 L. edodes cultivars. We evaluated the independence of every possible marker pair based on genotype data. Consequently, eight genetically independent markers were selected. The polymorphic information content values of the markers ranged from 0.269 to 0.764, with an average of 0.409. The markers could distinguish among 20 L. edodes cultivars and produced highly repeatable and reproducible results. The markers developed in this study will enable the precise identification of L. edodes cultivars, and may be useful for protecting breeders' rights.