1.Epidemiological and clinical studies of hepatocirrhosis and cancer of the liver.
Iwao SUGIMURA ; Minoru FUKUI ; Hisashi TOMARU ; Tsuneo NARISAWA ; Hiromasa MINEMOTO ; Yukio KONISHI
Journal of the Japanese Association of Rural Medicine 1986;35(4):735-741
Studies were performed on 44 cases of hepatocirrhosis found by laparoscopy and 75 cases resulting in death from hepatocirrhosis in order to shed light on the etiology of this disease.
Thanks to progress in radiographic diagnosis, it has become possible to detect minute tumors in the liver. In our hospital, six patients have been diagnosed as having less than 5 cm tumors in the liver. The diagnositic procedures that had led to the detection of the lesions were reviewed.
Furthermore, the treatment methods of liver cancer were analyzed using the ten cases.
2.Concentrated autologous bone marrow aspirate transplantation versus conservative treatment for corticosteroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus
Yohei TOMARU ; Tomokazu YOSHIOKA ; Junichi NANAKAMURA ; Hisashi SUGAYA ; Shigeo HAGIWARA ; Kento NAWATA ; Seiji OHTORI ; Masashi YAMAZAKI ; Hajime MISHIMA
Journal of Rural Medicine 2021;16(1):1-7
Objective: To compare the outcomes of steroid-associated osteonecrosis of the femoral head in patients with systemic lupus erythematosus who underwent conservative treatment and concentrated autologous bone marrow aspirate transplantationMethods: Osteonecrosis of the femoral head was classified according to the Japanese Investigation Committee system. Concentrated autologous bone marrow aspirate transplantation was performed by aspirating the bone marrow from both iliac crests and then transplanting it to the necrotic area after the core decompression. Patients with >2-year follow-up after the concentrated autologous bone marrow aspirate transplantation in our institution (Group I) and those with >2-year follow-up after the first hospital visit in a cooperative institution (Group II) were included in this study. After a randomized matching based on age, sex, type, stage, and etiology, the collapse rate in pre-collapsed stages and total hip arthroplasty conversion rate in all stages were compared between the two groups.Results: After the matching adjustment, 33 pairs of hips were included. Preoperatively, 1, 2, 16, and 14 hips were classified as types A, B, C1, and C2, respectively, and 15, 13, 2, and 3 hips were classified as stages 1, 2, 3A, and 3B, respectively. The collapse rates in the pre-collapsed stages were 68% and 39% in Groups I and II, respectively. Total hip arthroplasty conversion rates were 33% and 45% in Groups I and II, respectively. However, Group I had significantly higher and lower conversion rates in stages 1 and 3, respectively (both P<0.05).Conclusion: Conservative treatment may be preferable in stage 1 hips. In addition, concentrated autologous bone marrow aspirate transplantation may prevent further collapse in stage 3.