A 16-year-old Indian girl presented with increased facial hair growth, weight gain, amenorrhea and generalized weakness for the last 3 months. On examination she was found to have severe hirsutism, her modified Ferriman-Gallwey score was 24/36, she had broad purple striae on abdomen, hypertension and proximal myopathy. On investigations, the patient was found to have ACTH dependent Cushing's syndrome
Cushing Syndrome ; Hirsutism

D.R. presented with hirsutism, virilization and polycythemia. Hormonal assays, imaging studies and laparotomy revealed a steroid cell tumor of the ovary. The coexistence of ovarian tumor and polycythemia is discussed.
Human ; Female ; Adult ; POLYCYTHEMIA ; HIRSUTISM ; OVARY

Virilizing tumors during pregnancy are extremely rare. This case of a 33 year old, gravid 3 para 2, presented with hirsutism and clitoromegaly at 5 months age of gestation. Her past medical and menstrual histories were non-contributory. Ultrasound done during her prenatal check-up at 34 weeks age of gestation revealed an ovarian new growth on the left ovary features suggestive of a benign nature. On her 38th week of pregnancy, LTCS III with right tubal ligation and left salpingooophorectomy were performed and a baby boy weighing 3000 grams without any gross abnormalities was delivered. Histopathologically, the tumor proved to be a benign mucinous cystadenoma. This paper presented an ovarian mucinous cystadenoma with virilizing features that are transient and reversible. Therefore, an ovarian neoplasm should always be considered as a differential diagnosis for causes of virilization during pregnancy.
Human ; Female ; Adult ; HIRSUTISM ; PREGNANCY ; CYSTADENOMA, MUCINOUS

A 19 year old female patient presented with diffuse alopecia as her chief medical complaint. A clinical examination revealed hirsutism limited only to the on midline lower abdomen with elevated DHEA-S(dehydroepiandrosterone sulfate) and total testosterone levels. Polycystic ovarian disease (PCOD) was diagnosed during the treatment with dexamethasone and spironolactone, which was effective to improve her alopecia. We believe that, with increasing, concerns about hair conditions of teen-age girls there should be increasing chances for dermatologists to care for patients of PCOD first before other specialities in medicine.
Abdomen ; Alopecia* ; Dexamethasone ; Female* ; Hair ; Hirsutism ; Humans ; Ovarian Diseases* ; Spironolactone ; Testosterone ; Young Adult

Hypertrichosis refers to the increase of hair density or length beyond the accepted limits of normal for a particular age, race, or sex. It is an overgrowth of hair in androgen-independent areas and it differs from hirsutism, which refers to hair growth in women in areas of the body where hair growth is under androgen control. It may be classified into congenital and acquired types according to age of development, and localized or generalized types according to the range of involvement. Acquired localized hypertrichosis may occur secondary to infective or inflammatory diseases, traumas, drugs, fracture and cast, lymphedema, sympathetic dystrophy, topical steroid application, denervation, or congenital AV fistula. Any situation that results in persistent and repetitious inflammation in the dermis or individual susceptibility may cause hypertrichosis. We report two cases of acquired localized hypertrichosis associated with cellulitis and contusion.
Cellulitis* ; Continental Population Groups ; Contusions* ; Denervation ; Dermis ; Female ; Fistula ; Hair ; Hirsutism ; Humans ; Hypertrichosis* ; Inflammation ; Lymphedema

OBJECTIVE: To investigate the relationship between serum dehydroepiandrosterone sulfate (DHEAS) or free testosterone (FT) levels and aging. METHODS:One hundred and thirty one women without androgen excess symptoms such as oligomenorrhea or amenorrhea or hirsutism were recruited for measuring serum DHEAS, FT levels by radioimmunoassay. A P-value <0.05 was considered to be significant statistically. RESULTS: The levels of DHEAS were 211.39+/-33.01 microg/dL (twenties, n=10), 127.99+/-11.79 microg/dL (thirties, n=31), 94.30+/-7.49 microg/dL (forties, n=57) and 71.79+/-5.71 microg/dL (over fifties, n=33) respectively (mean+/-SE, P<0.001). The levels of FT were 3.98+/-0.94 pg/ml (twenties, n=10), 3.37+/-0.47 pg/mL (thirties, n=31), 2.68+/-0.30 pg/mL (forties, n=57) and 1.97+/-0.28 pg/mL (fifties, n=33) respectively (mean+/-SE, P=0.030). Mean value declining of DHEAS (r=-0.48865, P<0.0001) was bigger than those of FT (r=-0.29334, P<0.0007). CONCLUSION: Both DHEAS and FT levels decline with age and DHEAS decreases more steeply than FT.
Aging ; Amenorrhea ; Dehydroepiandrosterone ; Dehydroepiandrosterone Sulfate ; Female ; Hirsutism ; Humans ; Oligomenorrhea ; Radioimmunoassay ; Testosterone

OBJECTIVE: To investigate the relationship between serum dehydroepiandrosterone sulfate (DHEAS) or free testosterone (FT) levels and aging. METHODS:One hundred and thirty one women without androgen excess symptoms such as oligomenorrhea or amenorrhea or hirsutism were recruited for measuring serum DHEAS, FT levels by radioimmunoassay. A P-value <0.05 was considered to be significant statistically. RESULTS: The levels of DHEAS were 211.39+/-33.01 microg/dL (twenties, n=10), 127.99+/-11.79 microg/dL (thirties, n=31), 94.30+/-7.49 microg/dL (forties, n=57) and 71.79+/-5.71 microg/dL (over fifties, n=33) respectively (mean+/-SE, P<0.001). The levels of FT were 3.98+/-0.94 pg/ml (twenties, n=10), 3.37+/-0.47 pg/mL (thirties, n=31), 2.68+/-0.30 pg/mL (forties, n=57) and 1.97+/-0.28 pg/mL (fifties, n=33) respectively (mean+/-SE, P=0.030). Mean value declining of DHEAS (r=-0.48865, P<0.0001) was bigger than those of FT (r=-0.29334, P<0.0007). CONCLUSION: Both DHEAS and FT levels decline with age and DHEAS decreases more steeply than FT.
Aging ; Amenorrhea ; Dehydroepiandrosterone ; Dehydroepiandrosterone Sulfate ; Female ; Hirsutism ; Humans ; Oligomenorrhea ; Radioimmunoassay ; Testosterone

We have experienced 3 cases of Cornelia de Lange syndrome in Korean female infants. They showed typical clinical features of a microbrachycephaly, hirsutism and characteristic face with low forehead bushy eye brows, antimongolian slant, large and depressed briedge of nose, thin protruding lips with down turning of the corners and micrognathia. They also had skeletal abnormalities and chromosomal abnormalities. The diagnosis was established by clinical, laboratory and X-ray findings. The brief review of literature was made.
Chromosome Aberrations ; De Lange Syndrome* ; Diagnosis ; Female ; Forehead ; Hirsutism ; Humans ; Infant ; Lip ; Nose

OBJECTIVES: To investigate the distribution and functional significance of CYP11alpha (tttta)n microsatellite polymorphism in Korean patients with polycystic ovary syndrome MATERIALS AND METHODS: Analysis of CYP11alpha(tttta)n microsatellite polymorphism was carried out on DNA samples from 97 patients with polycystic ovary syndrome and 70 normal controls. Comparison were done between PCOS patients and controls concerning CYP11alpha (tttta)n microsatellite polymorphism genotype or allele frequencies. RESULTS: The most frequent allele observed in the controls was an allele with six repeats (60.7%). Significant difference in the frequency of genotype (4R (-) genotype) having no copy of four-repeat-allele were observed between PCOS patients and controls (66.0% vs 34.0%, p=0.038, OR=1.939). But no significant difference was observed in the serum levels of total testosterone or free testosterone between 4R (+) genotype and 4R (-) genotype among PCOS patients. However, hyperandrogenic PCOS patients with 4R (+) genotype showed a higher serum testosterone levels compared to controls (mean+/-S.D: 0.49+/-0.21 ng/ml vs 0.37+/-0.18 ng/ml, p=0.037). CONCLUSION: The alleleic distribution of CYP11alpha (tttta)n microsatellite polymorphism in Korean subjects were different from those reported in Caucasians. CYP11alpha (tttta)n microsatellite polymorphism was associated with polycystic ovary syndrome in the Korean population, and may play a role in the synthesis of androgens in patients with polycystic ovary syndrome.
Alleles ; Androgens ; DNA ; Gene Frequency ; Genotype ; Hirsutism ; Humans ; Hyperandrogenism ; Microsatellite Repeats* ; Polycystic Ovary Syndrome* ; Testosterone

The Cornelia de Lange syndrome is characterized by severe growth and mental retardations and a cluster of minor malformations, the facial appearance being most characteristic. In the present paper, we shall report I case of this syndrome in Korean male infant and the variability of de Lange syndrome is discussed. The bady showed hirsutism, low forehead coved with lanugo-like hair, bushy eyebrows that meet in the midline, long curely eyelashes as well as low pitched, growling cry and skeletal abnormalities of hand bones. There is no positive family history and the karyotype was normal. Although the de Lange syndrome has received more interest there is no agreement as to the possible cause.
De Lange Syndrome* ; Eyebrows ; Eyelashes ; Forehead ; Hair ; Hand Bones ; Hirsutism ; Humans ; Infant ; Karyotype ; Male