The purpose of this study was to investigate the physiological and psychological effects of sit to stand exercise using a video game. Twelve young male adults performed sit to stand exercise with a video game and without a video game. Heart rate, oxygen consumption (VO₂), electromyogram of lower limbs (%MVC) and perceived exertion (RPE) were measured during exercise. Mood states (POMS) were measured before and after exercise. There were no significant differences in physiological measurements between the two conditions. On the other hand, depression scale was significantly decreased after exercise only in the game condition. These results suggest that sit to stand exercise with a video game may have positive psychological effects without change in physiological load compared to the same exercise without a video game.