1.Malignant Transformation Of Breast Ductal Adenoma: A Diagnostic Pitfall
Hiroko Hayashi ; Hiroshi Ohtani
The Malaysian Journal of Pathology 2015;37(3):281-285
We present what is believed to be the first report of heterogeneous carcinoma arising from breast ductal
adenoma. A 57-year-old woman presented with a nodule in her right breast. Histological examination
of a vacuum-assisted biopsy specimen revealed epithelial tubular proliferation and papillary apocrine
epithelium. The myoepithelial cells lining the tubules were confirmed by immunohistochemistry.
The nodule had increased in size 18 months later and tumorectomy was performed. The surgical
specimen revealed proliferating apocrine epithelium with sheet-like and cribriform architecture
within a mammary duct. Some myoepithelial cells showed irregular proliferation around the tubular
epithelium. All three components, including apocrine, myoepithelial and glandular cells, showed
prominent nuclear atypia and significant mitotic activity. The patient was diagnosed with malignant
transformation of ductal adenoma. The malignant potential of ductal adenoma has not previously
been discussed, but this heterogeneous carcinoma could represent a serious pitfall in the diagnosis
of ductal adenomas.
2.Changes of ventilatory function in patients with bronchial asthma during swimming training in a hot spring pool.
Yoshiro TANIZAKI ; Haruki KOMAGOE ; Michiyasu SUDO ; Chiharu OKADA ; Hiroshi MORINAGA ; Jun OHTANI ; Ikuro KIMURA
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 1984;47(2):99-104
4.Clinical effects of spa therapy on patients with bronchial asthma and characteristics of its action mechanisms.
Yoshiro TANIZAKI ; Haruki KOMAGOE ; Michiyasu SUDO ; Hiroshi MORINAGA ; Jun OHTANI ; Ikuro KIMURA
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 1985;48(2):99-103
Twenty-nine patients with bronchial asthma received spa therapy at Okayama University Medical School, Misasa Branch Hospital. Twenty out of 29 cases were steroid-dependent intractable asthma.
Spa therapy was markedly effective in 8 cases (27.6%), moderately effective in 14 cases (48.3%), slightly effective in 5 cases (17.2%) and not effective in 2 cases out of 29 cases.
Spa therapy was more effective in the cases with age over 40 years than in the cases under 40 years. Non-atopic type asthma was more successfully treated with spa therapy compared to atopic type asthma. Regarding pathophysiological classification, spa therapy was greatly effective in the cases with bronchiolar obstruction and with hypersecretion.
5.Temporary External Bypass during Abdominal Aortic Aneurysm Operation: Two Patients with Heart Failure of Aortic Dissection.
Hiroshi Yamamoto ; Tadahiro Sasajima ; Masashi Inaba ; Norifumi Ohtani ; Masahiko Ishikawa ; Nobuyoshi Azuma ; Nobuyuki Akasaka ; Kazutomo Goh ; Yoshihiko Kubo
Japanese Journal of Cardiovascular Surgery 1995;24(3):186-189
We report two cases of an abdominal aortic aneurysm, one with congestive heart failure, and the other with a dissecting aortic aneurysm (type IIIb), who underwent an aorto-bifemoral bypass operation under a temporary external axillofemoral bypass. In one patient (Case 1, a 74-year-old male), who had an abdominal aortic aneurysm with congestive heart failure due to aortic valve insufficiency and stenosis, perioperative transesophageal echocardiography demonstrated that, with a temporary external axillofemoral bypass, the regurgitant doppler signal was unchanged during the cross-clamping period of the abdominal aorta. In the other patient (Case 2, a 71-year-old male), who had a dissecting thoracoabdominal aortic aneurysm with the lower abdominal aorta having a true aneurysm formation, the transesophageal echocardiography demonstrated that, with a temporary external axillofemoral bypass, the false lumen of the dissecting thoracic aneurysm had no change in size during the cross-clamping period of the abdominal aorta. Thus, a temporary external axillofemoral bypass might avoid any unfavorable hemodynamic effect during and after the abdominal aortic clamping in patients suffering from an abdominal aortic aneurysm with cardiovascular complications.