1.Usefulness of ISN/RPS Classification of Lupus Nephritis.
Journal of Korean Medical Science 2009;24(Suppl 1):S7-S10
About 50-80% of patients with lupus suffer from lupus nephritis which is one of major causes of morbidity and mortality. Renal pathologists and nephrologists should evaluate the degree of histological damages to establish therapeutic plans for lupus nephritis. In order to standardize definitions, to emphasize clinically relevant lesions, and to improve interobserver reproducibility, the International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification was proposed. Recently, several retrospective validation studies concerning the utility of the ISN/RPS classification, especially among class IV, were performed. In these reports, reproducibility is improved by the definition of diagnostic term, but the outcome related with classification, especially in class IV, is controversial. We performed retrospective analysis of 99 biopsy- proven subjects with lupus nephritis in our facility using the ISN/RPS classification. The class IV-G group tended to exhibit a worse renal outcome, but the difference compared with IV-S was not significant. In a Cox proportional hazards models, Independent histological predictors of poor renal outcome were extracapillary proliferation, glomerular sclerosis and fibrous crescents, while hyaline thrombi and fibrous adhesions were of favorable renal outcome. Both were similarly observed in IV-G and IV-S. The more qualitative categorization by the response to standard treatment may be needed to emphasize clinically relevant lesion related to renal outcome.
Cell Proliferation
;
Humans
;
Kidney/pathology
;
Kidney Glomerulus/*pathology
;
Lupus Nephritis/*classification/*diagnosis
;
Nephrology/*methods/standards
;
Proportional Hazards Models
;
Sclerosis/pathology
;
Societies, Medical
;
Treatment Outcome
2.Gender differences in preferences for mentoring styles and topics in academic medicine in Japan
Hiroki Mishina ; Ken Sakushima ; Kenei Sada ; Junji Koizumi ; Takashi Sugioka ; Naoto Kobayashi ; Masaharu Nishimura ; Junichiro Mori ; Hirofumi Makino ; Mitchell D Feldman ; Shunichi Fukuhara
Medical Education 2014;45(1):1-7
Objective: To evaluate gender differences in mentee’s preference for mentoring styles and topics in academic medicine in Japan.
Methods: We conducted a cross-sectional questionnaire survey of mentees at 6 graduate schools of medicine in Japan from December 2011 through January 2012. The study participants were 1700 Japanese-speaking graduate students and postdoctoral fellows. The primary outcome was the percentage of respondents who desired to be mentored with a particular style or topic.
Results: A total of 676 (227 women) mentees responded to the survey. Women were less likely than men to prefer a hierarchical mentoring relationship (men, 82%; women, 71%; p=0.001) but were more likely to desire a mentor for career consultation (men, 51%; women, 64%; p=0.001). Women were more likely than men to want guidance in developing a research portfolio (men, 85%; women, 90%; p=0.04), in computer skills/statistical skills (men, 68%; women, 81%; p=0.001), and in long-term career planning (men, 38%; women, 50%; p=0.003).
Conclusion: Women mentees in Japan express different preferences for mentoring styles and topics from men. Mentors in Japan must take these differences into consideration.