The effects of human atrial natriuretic peptide (HANP, carperitide) were studied in 21 patients undergoing mitral valve surgery. The patients were randomized to receive either no carperitide treatment (control group, n=10) or carperitide (HANP group, n=11). Their hemodynamic status, diuresis and renal function were assessed perioperatively. The HANP group received continuous intravenous infusion of carperitide for 3 hours at a rate of 0.05μg/kg/min 3 hours after cardiopulmonary bypass. The HANP group had significantly lower systemic vascular resistance and less temperature difference between the rectum and the sole, and significantly greater cardiac index compared with those in the control group during infusion of carperitide, suggesting the improvement of cardiac performance by reducing afterload. The HANP group also had greater urinary output during the administration of carperitide, suggesting the significant diuretic effect of the regimen. The results indicated that the administration of carperitide may be a viable alternative strategy for the management of patients with postoperative heart failure. However, since transient oliguria was observed in 2 hypovolemic patients after the discontinuation of carperitide, careful monitoring is required during and after the infusion of the regimen in such patients.

Thirty six patients with post-infarction complications underwent operation, and the postoperative and late follow-up results were analyzed. There were post-infarction ventricular septal perforation (VSP) in 9 patients and left ventricular aneurysm formation in 27 patients. The operative indications were poor physical work capacity in 13, cardiogenic shock or severe congestive heart failure in 10, left ventricular thrombus in 7, severe ventricular arrhythmia in 6, and repeated angina in 6. Left ventricular aneurysmectomy was performed in 14 patients and VSP closure was in 8. Coronary arteries were simultaneously bypassed in 14 patients. Three patients were died of sudden postoperative arrhythmia 10 days, 55 days and four years after operation. All survivors except two patients with preoperative massive cerebral infarction or prolonged heart failure were in New York Heart Association Class I or II in their late postoperative periods. However, five patients in whom the significant coronary lesion had not been bypassed or the bypassed grafts had occluded complained of mild angina after operation. Postoperative arrhythmia was one of major factors in the late results and simultaneous coronary artery bypass grafting was important to improve the symptoms in the late postoperative periods.