Objective: To show the preventive effect of dietary supplements on metabolic syndrome.
Methods: Twenty dietary supplements were examined for inhibition of α-glucosidase, absorption of sugar in mice, lipids accumulation and adiponectin production in rat visceral adipocytes.
Results: In twenty dietary supplements, Bombyx mori and mulberry leaves inhibited rat intestinal α-glucosidase more than acarbose, and inhibited absorption of sugar in mice. In visceral adipocytes, Ganoderma lucidum, mate and Japanese yew inhibited accumulation of lipid and Artemisia Capillaris Flowers and Ground-ivy increased production of adiponectin in rat visceral adipocytes.
Conclusion: Mulberry leaves, Bombyx mori, Glechoma hederacea, Artemisia Capillaris Flowers are natural products which offer promise in the prevention of diabetes and metabolic syndrome. Incorporating dietary supplements into a treatment plan with medicines with similar effects requires further study.

Liver fibrosis reflects tissue scarring in the liver due to the accumulation of excessive extracellular matrix in response to chronically persistent liver injury. Hepatocyte cell death can trigger capillarization of liver sinusoidal endothelial cells, stimulation of immune cells including macrophages and Kupffer cells, and activation of hepatic stellate cells (HSCs), resulting in progression of liver fibrosis. Liver cirrhosis is the terminal state of liver fibrosis and is associated with severe complications, such as liver failure, portal hypertension, and liver cancer. Nevertheless, effective therapy for cirrhosis has not yet been established, and liver transplantation is the only radical treatment for severe cases. Studies investigating HSC activation and regulation of collagen production in the liver have made breakthroughs in recent decades that have advanced the knowledge regarding liver fibrosis pathophysiology. In this review, we summarize molecular mechanisms of liver fibrosis and discuss the development of novel anti-fibrotic therapies.

Liver fibrosis reflects tissue scarring in the liver due to the accumulation of excessive extracellular matrix in response to chronically persistent liver injury. Hepatocyte cell death can trigger capillarization of liver sinusoidal endothelial cells, stimulation of immune cells including macrophages and Kupffer cells, and activation of hepatic stellate cells (HSCs), resulting in progression of liver fibrosis. Liver cirrhosis is the terminal state of liver fibrosis and is associated with severe complications, such as liver failure, portal hypertension, and liver cancer. Nevertheless, effective therapy for cirrhosis has not yet been established, and liver transplantation is the only radical treatment for severe cases. Studies investigating HSC activation and regulation of collagen production in the liver have made breakthroughs in recent decades that have advanced the knowledge regarding liver fibrosis pathophysiology. In this review, we summarize molecular mechanisms of liver fibrosis and discuss the development of novel anti-fibrotic therapies.

Although it is very important in view of public health to understand the mosquito breeding sites and key reservoirs existing around residential areas, such information is lacking in temporary housing sites constructed after the serious tsunami strikes on 26 December 2004 in Sri Lanka. This study clarified the situation regarding mosquito breeding 14 months after the tsunami in Sri Lanka by surveying temporary housing and non-damaged village areas, and also by examining people‘s knowledge related to mosquito breeding sites and mosquito-borne diseases. The relative frequency of mosquito larvae in wastewater pools was significantly higher in temporary housing than in village areas. The prevalence of storage containers at temporary housing and village areas was not significantly different. It was found that wastewater pools in temporary housing sites were the main breeding site of Culex quinquefasciatus Say, Cx. tritaeniorhynchus Giles, and Aedes albopictus Skuse whereas storage containers in village areas were the main breeding site of Cx. quinquefasciatus and Ae. albopictus. No mosquitoes bred in storage containers in the temporary housing but some Ae. albopictus did so in village areas. The questionnaires indicated a significant difference between residents of temporary housing and villages in response to the question: Do you know where mosquitoes breed? The proportion of the “wastewater pools” response was higher among temporary housing residents than among village residents. This knowledge among temporary housing residents may relate to the fact that wastewater pools are latent breeding sites for mosquitoes in temporary housing sites. Although residents in the temporary housing sites put salt and abluent into storage containers to prevent mosquitoes from breeding, wastewater pools receiving a constant supply of wastewater provided the best breeding site for mosquitoes.