Objective:Objective To investigate the clinical effect of Misoprostol promoting cervical mature for before abortion . Method:8 patients of induced abortion operation were enrolled in our hospital from January 2013 to January 2012 , and were randomly divided into observation group and control group, each group had 124 cases, the observation group was given misoprostol which placed in cvaginal fornix preoperative , and control group without prompting cervical ripening drug. Observation of cervical dilatation, degree of pain, operation time and bleeding volume in two groups of patients. Result: The efficiency rate of observation group was 96. 8%, significantly higher than 82. 3% in the control group, the difference was statistically significant (P<0. 05);there were 100 cases of painless in the observation group , and 51 cases in control group, the degree of pain in the observation group were obviously improved than the control group , the difference was statistically significant (P<0. 05);,operation time of treatment group was shorter than the control group, the amount of bleeding surgery was significantly lower than the control group, the differences were statistically significant (P<0. 05). Conclusion:Misoprostol is given before induced abortion , can relax cervical effectively, shorten operation time, reduce the patients' pain, reduce the difficulty of operation, increase the safety of operation , is worth the clinical promotion.