In 1964, Blumberg B.S. found the antigen Au, a surface antigen of hepatitis B virus (HBSAg). Then the serum properties of hepatitis A, D, E and C were found, respectively. In 1995, the new hepatitis viruses including GB agent, hepatitis G virus, hepatitis TTV and hepatitis SEN viruses were found. In 1992, the vaccine of hepatitis A was introduced. There were many improvements of the treatment of hepatitis B and hepatitis C by the traditional and modern medicine
Hepatitis ; Hepatitis B virus ; hepatitis A ; hepatitis C ; Hepatitis Viruses

A serum panel from Vietnamese blood donors including 225 positive and 300 negative sera has been used to evaluate antigenicity of 8 hepatitis C virus (HCV) recombinant proteins cloned and expressed in Escherichia coli c22-3, c33/1b, mosaic NS4, NS5a/1b proteins presented identical results while third-generation HCV recombinant immunoblot assay (RIBA-3) sera were positive. All recombinant proteins highly detected HCV RNA positive sera known genotype (80-95%). NS3-16/6a demonstrated greater reactivity than other proteins, indeed a good protein (c33c/1b) in the same region while HCV genotype was 6a (specific HCV genotype in Vietnam).
Hepatitis C virus ; Escherichia coli

100 patients with HCC, diagnosed by the clinical, Alpha Foetoprotein, imaging and cytological criteria; 50 patients in the control group. Anti HCV are performed by the techniques of EIA. HCV RNA is detected by RT PCR (reverse transcriptase PCR). The molecular biological techniques are performed at the Central Bio-medical laboratory in Hanoi Medical School. The frequency of serum anti HCV(ELISA) and especially of HCV RNA (RT-PCR) in the patients with HCC is also significantly higher than the one in the group of control: Anti HCV and HCV RNA.The co infection HBV-HCV is not significant in the hepatocarcinogennesis in our study. This study showed that hepatitis B virus is an important etiologic factor in the hepatocarinogenesis in Thua Thien Hue. The role of HCV is also remarkable and the co infections HCV-HBV are not significant in our study
Carcinoma, Hepatocellular ; Hepatitis C virus

A study on patients with hepatocellular carcinoma in HuÕ hospital during 1990-1995 and 2000 has shown that the disease was increasingly during 1990-2000, the morbidity rate was predominant higher than this in women, and average age of patients was reduced. The major etiological agent was hepatitis B virus. The alcohol played a combined role with hepatitis B virus in the hepatocellular carcinoma. The role of hepatitis C virus was not statistical significant.
Carcinoma, Hepatocellular ; Hepatitis C virus ; Hepatitis B virus

Identified ratio of infectious HBV, HCV in 723 specimens of patient with HIV positive. As a result, ratio infectious HIV-HBV: 20,6%; HIV-HCV: 88.4% HIV-HBV-HCV: 19.1%. Ratio infectious HBV, HCV in male is higher than female. In 10 children age from new born to 18 months with HIV positive, 40% with HIV antigen P24 positive, 30% HCV positive.
HIV ; Hepatitis B virus ; Hepatitis C virus ; HIV Infections

Hepacivirus ; pathogenicity ; Hepatitis C ; virology ; Receptors, Virus

In 1997, the Blood Bank in ViÖt §øc hospital discovered 14 cases of HIV1 positive: 1 case was not enough serum to make further test, 1 was regular donor with HIV positive, Anti HCV negative, HBsAg negative. The incidence of Anti HCV (Hepatitis C) was 12/13 positive (92.3%). The incidence of heroin users was 12/13 (92.3%). The incidence of HBsAg (Hepatitis B) was: 1/13 positive (7.8%).
HIV ; Hepatitis C virus ; Hepatitis B Surface Antigens ; Blood Donors

Hepatitis C virus ; Chronic ; Hepatitis B virus measurement ; Therapeutic procedure ; Hepatitis

The cytokine patterns secreted by T cells at the site of viral replication may influence the final outcome of HBV and HCV infection. The different cytokine profiles of T cells within the liver in chronic HBV (Th0/Th2 cytokine) and HCV (Th1 cytokine) infections illustrate a different behavior of the local immune response in these two infections. The predominance of Th1-type cytokine responses has been reported to play an important role in viral clearance of patients with both acute and chronic hepatitis B. In contrast, a combined Th1-and Th2-like responses were found in chronic hepatitis C, exhibiting a pattern like that of acute hepatitis C with chronic evolution. It suggests that different patterns of cytokine expressions between HBV and HCV infection involve the difference in chronicity in each infection.
Cytokines* ; Hepacivirus ; Hepatitis B virus ; Hepatitis B, Chronic* ; Hepatitis C ; Hepatitis C, Chronic ; Hepatitis, Chronic* ; Humans ; Liver ; T-Lymphocytes

Serum samples from 123 males and 123 females collected by age in 1996 were analyzed for antibodies against surface antigen of Hepatitis B virus and C22-3, C200 antigens of Hepatitis C virus. Sera from the children under the age of 10 showed 30% seropositivity to the surface antigen of Hepatitis B virus, 33.3% in 10~19 year group, 20% in 20~29 year group, 17.6% in 30~39 year group, 3.3% in 40~49 year group, 5.9% in 50~59 year group, 8,3% in 60~69 year group, 2.9% in 70~79 year group, but antibody could not found in 80~86 year group. 12 out of 123 male sera were positive, 19 out of 123 female sera were positive and overall rate of positivity of antibody against surface antigen of Hepatitis B virus was 12.6%. Serum samples from peoples under the age of 30 had not antibody against C22-3, C200 antigens of Hepatitis C virus. The positivity rate was 2.9% in 30~39 year group. 5 out of 30 sera from 40~49 year age group were positive, and 3 positive sera showed extremely high titer (1:524,288) but the titers of two remaining sera were 1:32, 1:8,192 respectively. 5.9% was positive in 50~59 year group, 8.3% in 60~69 year group, 11.8% in 70~79 year group but all negative in 80~86 yea. group. 6 out of 123 male sera were positive (4.9%), 9 out of 123 female sera were positive (7.3%). Overall .ate of positivity of antibody against C22-3, C200 antigen of Hepatitis C virus was 6.1%. None out of 246 sera had both antibodies against Hepatitis B virus and Hepatitis C virus.
Antibodies* ; Antigens, Surface ; Child ; Female ; Hepacivirus* ; Hepatitis B virus* ; Hepatitis B* ; Hepatitis C* ; Hepatitis* ; Humans* ; Male