No abstract available.
Antigens, Surface* ; Hepatitis B* ; Hepatitis*

Background: Vietnam is located in the endemic region of hepatitis B virus (HBV) infection, but no data of occult HBV infection was reported at present. Objectives: To investigate the prevalence of occult HBV infection in different ethnics of people and generations. Subjects and method: 80 voluteers with HbsAg negative from five different ethnics: Kinh, Tay, Mong, Giay and Dao in a Chino \ufffd?Vietnamses border province (Lao Cai) were enrolled in the study. After HBV-DNA was extracted, nested PCR of S gene and of Core-promoter/Pre-core region were used to detect HBV-DNA. Specifying nucleotide sequence was confirmed by direct sequencing. Results:The prevalence of occult HBV infection in population study was very high 73/80 (91,3%) by nested PCR of Core-promoter/Pre-core, significantly more sensitive than nested PCR of S gene (26,3%) (p<0,0001). The prevalence of occult HBV infection was notdifferent between ethnics of people or between children, adults. Conclusion: Occult HBV infection in Vietnamese is very common; however, nationwide further studies should be carried out to confirm this preliminary results and evaluate the impact of occult HBV infection in Vietnam.
Hepatitis B virus ; Hepatitis B Surface Antigens ;

Hepatitis B virus (HBV) transmission mainly occurs for the public active persons. Test diagnose HBV, that is cheap cost, adjacent easy and effective relatively result, is HBsAg and anti-HBs. If test is positive HBs, body is infecting HBV. If test is positive anti-HBs, body were infected HBV. Study on 1138 people with age of from 0-60 year old, were divided into 10 groups according to WHO. Results shown that positive HBsAg related with age, group of age from 0-29 has the directly proportional rate, age increased according to disease increased. But age of from 30 - 60, the disease related with inversely proportional rate with age. From 20-60 years old, HBV infected rate is fluctuated from 40-45%.
Hepatitis B Surface Antigens ; Hepatitis B virus

The indicators are usually used in diagnosis of Hepatitis B were HBsAg, HBeAg antigens and SGOT, SGPT. 150 persons with the positive HBsAg among persons who was waiting for injection of Hepatitis B vaccine in the Highland institute of epidemiology tested have shown that there was closely relation between these indicators which demonstrated that there was an interaction between person and pathogen via immunological and biochemical reactions.
Hepatitis B virus ; Hepatitis B Surface Antigens

51 patients with acute hepatitis B were studied at Infectious and Tropical Diseases Department, Hue Central Hospital with criteria of clinical features, transaminase 5 times higher than normal upper limit and positive HbsAg at hospitalized time. 62% of them admitted hospital from 1 to 14 days after developed disease, reminder admitted hospital later than 15thday. Symptoms: 45,1% patients no fever; 88,2% oligouria and dark urine; 58,8% without swell of liver; 9,8% bleeding; 9,8% faint. Test results: there were 11% of patients with prothrombin <60%, 82,4% with bilirubin <340µg/l. 62,7% with De Ritis<1, 35,3% with HbeAg(+) and 33,3% with HbsAg (+) remained for 6 months. HbsAg positive remained for 6 months is associated with the group of patients admitted hospital later than 15thday (X2=5.1, P<0,05), the group with no fever (X2=10.1, P<0,05), the group with oligouria and dark urine (X2=13.6, P<0,05) and the group with jaundice (X2=5.1, P<0,05). The associations also existed between bilirubin level <340µg/l and the remained HbsAg (+) for 6 months and HbsAg (+) at the patients’ admission and the remained HbsAg (+) for 6 months (X2=5.5, P<0,05 and X2=31.3, P<0,05, respectively). The latter is strongly positive association.
Hepatitis B ; Hepatitis B Surface Antigens

Two positive clones inserted DNA fragment of HBV coded for intracellular HBsAg synthesis from 2 strains of P.pastoris: GS115-47-4 (Mut+ His 4) and KM71-47-1 (Muts; His4 arg4 aox1: ARG4) were selected for developing a DNA recombinant hepatitis B vaccine in laboratory scale. Different types of growth media and expression media were used for the study on HBsAg expression levels from those two clones. The highest level of HBsAg - 1318mcg/l with MGYH/MMH medium after 96h and 2220 mcg/l with BMGY/BMMY medium after 72h of induction was obtained in clone GS115-47-4 and 241 mcg/l after 48h and 1680 mcg/l after 48h in clone KM71-47-1 observed were respectively.
Hepatitis B Surface Antigens ; DNA

Out of 160 individuals, who were positive with HBsAg in primary blood testing, 122 cases have performed a further blood test after 6 months to identify HBsAg status. Results showed that there is no significant difference between two sexes in becoming HBsAg carrier (p>0.05). The prevalence of HBsAg carriers in general population is about 5.76%. There is close correlation between the age of onset HBV infection and the risk of becoming HBsAg carrier (r = 0.84; p<0.01).
Hepatitis B Surface Antigens ; DNA ; Hepatitis B ; Hepatitis B virus

No abstract available.
Antibodies* ; Hepatitis B Surface Antigens* ; Hepatitis* ; Prevalence*

Research on 39 patients with acute virus hepatitis and 33 patients with chronic virus hepatitis, 9 patients have clinical cirrhosis symptoms. All of them suffer HbsAg (+) and liver function disorderly. Results: in lower 40 ages group, the incidence of acute virus hepatitis higher than chronic virus hepatitis and cirrhosis. Man with hepatitis and cirrhosis higher than woman byfar (80,2% vs 19,8%). Reducing aglobulia, pigment blood ……….. in man patients with acute virus hepatitis, chronic virus hepatitis are higher than healthy people. Number of Glomerule in chronic hepatitis and cirrhosis group and man with acute hepatitis reduce significantly compare health people. In suffer acute virus hepatitis, there are different significantly between nomal acute virus hepatitis and severe acute virus hepatitis
Hepatitis ; Liver ; Hepatitis B Surface Antigens

No Abstract Available.
Hepatitis B e Antigens* ; Hepatitis B Surface Antigens*