1.Seropositivity of anti-HBs titer among college students several years after completion of the primary hepatitis B vaccination series
Monique P. Valerio-Fabros ; Jay Ron O. Padua
Pediatric Infectious Disease Society of the Philippines Journal 2024;25(2):11-21
BACKGROUND
The Philippines is hyperendemic for hepatitis B infection. Vaccination is crucial for protection. Local data on the antibody response after completion of the primary vaccination series is limited.
OBJECTIVEThis study aimed to measure the anti-HBs levels among college students who completed primary hepatitis B vaccination series, compare seropositivity across stratified groups and correlate anti-HBs levels with the time elapsed since the last vaccine dose.
METHODSThis cross-sectional study included 111 college students in health-related courses with immunization record showing the complete primary Hepatitis B vaccination series. Participants were stratified based on the following vaccination schedules: 0-1-6-month group; 0-1-2-month group; and booster group. Anti-HBs titers were determined.
DATA ANALYSISStatistical analyses included One-way ANOVA, Kruskal-Wallis test, Fisher’s Exact test and Shapiro-Wilk normality test. Kaplan-Meier Survival Estimate assessed the probability of anti-HBs seropositivity over time. Data were analyzed using STATA 13.1.
RESULTSThe baseline characteristics of the study population were homogenous. The median anti-HBs titer several years after primary vaccination was low at 2.9 mIU/mL. Participants in the booster group had the highest seropositivity rate (57.14%) with a median titer of 30.16 mIU/mL. There was an inverse relationship between anti-HBs titer and elapsed time since the last vaccine dose. Kaplan-Meier Survival Estimate showed that the seropositivity decreases to 90.56% after 15.8 years, 51.3% after 17.5 years, and 2.97% at 18 years.
CONCLUSIONThis study revealed low anti-HBs titers among students who previously completed primary vaccination series, with no significant difference between two schedules. Booster doses resulted in the highest seropositivity. Over-all, seropositivity declines over time.
Hepatitis B ; Hepatitis B Antibodies
2.Preventin of Hepatitis B.
Journal of the Korean Pediatric Society 1983;26(5):421-427
No abstract available.
Hepatitis B*
;
Hepatitis*
3.Vectical Transmission of Hepatitis B.
Journal of the Korean Pediatric Society 1983;26(5):412-412
No abstract available.
Hepatitis B*
;
Hepatitis*
4.Hepatitis B Virus-Associated Nephropathy.
Korean Journal of Nephrology 2000;19(6):987-988
No abstract available.
Hepatitis B*
;
Hepatitis*
6.Anti-viral Treatment in Chronic Viral Hepatitis B.
Journal of the Korean Academy of Family Medicine 2003;24(6):503-509
No abstract available.
Hepatitis B*
;
Hepatitis*
7.Prevention of Hepatitis B.
Journal of the Korean Pediatric Society 1986;29(4):1-4
No abstract available.
Hepatitis B*
;
Hepatitis*
8.Antiviral Therapy Hepatitis B in Renal Transplant Recipients.
Korean Journal of Nephrology 2006;25(6):877-885
No Abstract available.
Hepatitis B*
;
Hepatitis*
;
Transplantation*
9.A comparative study on the efficacy of low-dose intradermal hepatitis B vaccination.
Journal of the Korean Academy of Family Medicine 1992;13(1):28-34
No abstract available.
Hepatitis B*
;
Hepatitis*
;
Vaccination*
10.Knowledge, attitude, practice survey (KAP) on liver disease, hepatitis B and EPI at Thanh Hoa
Journal of Preventive Medicine 2001;11(2):18-23
The KAP survey on liver disease, hepatitis B and EPI was conducted in Quang Xuong and Ngoc Lac (Thanh Hoa) in October 2000. The results: there were more than 50% of interviewees giving completely correct answers on liver disease. Monthly visits of EPI staffs increased three times in Ngoc Lac to compare with this of 3 years ago. Radio/TV and loudspeakers are still the main ways to inform EPI activities. Knowledge of mothers on vaccination has been improved. The rate of having birth at CHS has increased in Ngoc Lac (from 6.2% to 34.2%)
Hepatitis, Chronic
;
hepatitis B
Result Analysis
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