Objective To study the X-ray and CT findings of pneumocystis carinii pneumonia(PCP)in AIDS.Methods 18 cases with PCP in AIDS proved by clinic and pathologically were collected.HIV antibody was positive in all cases.Chest radigraphy and CT scan were taken in all cases.The imaging findings were analysed.Results The typical features of PCP on radiography and CT included unsymmetric diffuse mesh or reticulo-nodular changes,symmetric ground-glass opacification and many more even lobar consolidations which distributed in bilateral hilar regions and middle-lower lung fields.The atypical manifestations included cystic lesions,lobar consolidation,hilar and/or mediastinal adenopathy,pleural effusion,pneumothorax,atelectasis,mass and cavity-mass.Conclusion Plain chest film and CT scan are of important value in diagnosis of PCP.It is possible to diagnose PCP in patients with typical imaging manifestations positive HIV and in combination with clinical data.

Objective To discuss the CT characteristics of AIDS's brain common disease,so that to improve the diagnostic level.Methods CT features of brain lesions in 25 patients with AIDS were retrospectively analyzed.Results Acute HIV encephalitis(n=6),CT features included low density at the basis festival area and the ventriculi laterals,no enhancement on contrast-enhanced scan in 1 case.Subacute HIV brain illness(n=5),CT images showed different degree of atrophy.Toxoplasmosis(n=4),CT images showed iso-dense tubercles with edema in the deep part of brain white matter or iso-dense circle at the edema area.Cytomegalovirus encephalitis(n=3),CT images showed symmetrical low density at bilateral cerebral occipital lobe,internal capsule and thalamus.Progressive multifocal leukoencepathy(n=3),CT showed multiple low density at the inferior surface of brain cortex,the gyri close of focus was clearer,and far of tapetum room system.Mixed infectious(n=4),mixed CT characteristics.Conclusion CT is beneficial in the differential diagnosis of brain disease in AIDS.

OBJECTIVE：To provide reference for improving the mechanism of drug supervision in Guangdong-Hong Kong-Macao Greater Bay Area. METHODS ：Based on the evolutionary game theory ，the stakeholders of Guangdong-Hong Kong-Macao Greater Bay Area in the stage of drug safety supervision were identified ；the evolutionary game model was established so as to obtain the behavioral selection and evolutionary stability strategy of the each party through and put forward the suggestions for improving the mechanism of drug supervision in Guangdong-Hong Kong-Macao Greater Bay Area. RESULTS & CONCLUSIONS：Based on evolutionary game theory ，the three-party evolutionary game model of drug administration ，drug inspection and manufacturing enterprises was established. According to the model established in this study ，it could be concluded that：when the compliance cost of the production enterprise was less than the sum of the violation cost and the bribery cost minus the additional income ，or less than the sum of violation cost and punishment and reputation lossminus the additional income ，the manufacturing enterprises could achieve the equilibrium state of compliance production ；the supervision probability was inversely proportional to the supervision cost ，and strict inspection was inversely proportional to inspection cost ；compliance productivity rate and strict detection rate were in direct proportion to the intensity of supervision and penalties ；the higher the supervision probability was，the higher the strict detection rate was ，and the compliance productivity would gradually increase. It is proposed to link enterprise information files ，lay the foundation of four party cogovernance ；introduce the “cost-benefit”supervision system ，make reasonable use of the third-party inspection institutions ；clarify the boundary of personnel responsibility ，and use the intelligent system for real-time supervision so as to promote the improvement of drug safety supervision in Guangdong-Hong Kong-Macao Greater Ba y Area.