1.Seventeen years of life support courses for nurses: where are we now?
Singapore medical journal 2017;58(7):453-455
The Life Support Course for Nurses (LSCN) equips nurses with the resuscitation skills to be first responders in in-hospital cardiac arrests. Seventeen years after the initiation of the LSCN, a confidential cross-sectional Qualtrics™ survey was conducted in May 2016 on LSCN graduands to assess the following: confidence in nurse-initiated resuscitation post-LSCN; defibrillation experience and outcomes; and perceived barriers and usefulness of the LSCN. The majority of respondents reported that the course was useful and enhanced their confidence in resuscitation. Skills retention can be enhanced by organising frequent team-based resuscitation training. Resuscitation successes should be publicised to help overcome perceived barriers.
2.Magnetic Resonance Elastography and Other Magnetic Resonance Imaging Techniques in Chronic Liver Disease: Current Status and Future Directions.
Cher Heng TAN ; Sudhakar Kundapur VENKATESH
Gut and Liver 2016;10(5):672-686
Recent advances in the noninvasive imaging of chronic liver disease have led to improvements in diagnosis, particularly with magnetic resonance imaging (MRI). A comprehensive evaluation of the liver may be performed with the quantification of the degree of hepatic steatosis, liver iron concentration, and liver fibrosis. In addition, MRI of the liver may be used to identify complications of cirrhosis, including portal hypertension, ascites, and the development of hepatocellular carcinoma. In this review article, we discuss the state of the art techniques in liver MRI, namely, magnetic resonance elastography, hepatobiliary phase MRI, and liver fat and iron quantification MRI. The use of these advanced techniques in the management of chronic liver diseases, including non-alcoholic fatty liver disease, will be elaborated.
Ascites
;
Carcinoma, Hepatocellular
;
Diagnosis
;
Elasticity Imaging Techniques*
;
Fatty Liver
;
Fibrosis
;
Hypertension, Portal
;
Iron
;
Liver Cirrhosis
;
Liver Diseases*
;
Liver*
;
Magnetic Resonance Imaging*
;
Non-alcoholic Fatty Liver Disease
4.Multiparametric MRI in Active Surveillance of Prostate Cancer: An Overview and a Practical Approach
Chau Hung LEE ; Teck Wei TAN ; Cher Heng TAN
Korean Journal of Radiology 2021;22(7):1087-1099
MRI has become important for the detection of prostate cancer. MRI-guided biopsy is superior to conventional systematic biopsy in patients suspected with prostate cancer. MRI is also increasingly used for monitoring patients with low-risk prostate cancer during active surveillance. It improves patient selection for active surveillance at diagnosis, although its role during follow-up is unclear. We aim to review existing evidence and propose a practical approach for incorporating MRI into active surveillance protocols.
5.Multiparametric MRI in Active Surveillance of Prostate Cancer: An Overview and a Practical Approach
Chau Hung LEE ; Teck Wei TAN ; Cher Heng TAN
Korean Journal of Radiology 2021;22(7):1087-1099
MRI has become important for the detection of prostate cancer. MRI-guided biopsy is superior to conventional systematic biopsy in patients suspected with prostate cancer. MRI is also increasingly used for monitoring patients with low-risk prostate cancer during active surveillance. It improves patient selection for active surveillance at diagnosis, although its role during follow-up is unclear. We aim to review existing evidence and propose a practical approach for incorporating MRI into active surveillance protocols.
6.Clinics in diagnostic imaging (157). Acinar cell carcinoma (ACC) of the pancreatic tail.
Marcus Jian Fu ONG ; Yee Lin TANG ; Cher Heng TAN
Singapore medical journal 2014;55(11):564-quiz 568
A 50-year-old Chinese man presented to the clinic with left hypochondrial pain, more than 10 kg of weight loss over a 3-month period, and a firm, large, ill-defined mass in the left upper quadrant. Contrast-enhanced computed tomography of the abdomen and pelvis revealed a well-circumscribed exophytic pancreatic mass with features suggestive of acinar cell carcinoma (ACC). The patient underwent chemotherapy and radiotherapy, with no evidence of local recurrence detected at one-year follow-up. He remains under close surveillance by his oncologist. Treatment for ACC includes surgical resection with adjuvant radiotherapy. Better overall survival is seen in patients with surgically resectable ACC as compared to those with the more common ductal cell carcinoma.
Carcinoma, Acinar Cell
;
diagnostic imaging
;
pathology
;
Humans
;
Male
;
Middle Aged
;
Pancreatic Neoplasms
;
diagnostic imaging
;
pathology
;
Tomography, X-Ray Computed
7.Renal-related adverse effects of intravenous contrast media in computed tomography.
Kheng Song LEOW ; Yi Wei WU ; Cher Heng TAN
Singapore medical journal 2015;56(4):186-193
Renal-related adverse effects of intravascular contrast media (CM) include contrast-induced nephropathy in computed tomography and angiography. While large retrospective studies have been published, the exact pathogenesis of this condition is still unknown. We review the main international guidelines, including the American College of Radiology white paper and the guidelines of European Society of Urogenital Radiology, Royal College of Radiologists and Canadian Association of Radiologists, as well as their references, regarding this subject. We present a simplified, concise approach to renal-related adverse effects of CM, taking into consideration the basis for each recommendation in these published guidelines. This will allow the reader to better understand the rationale behind appropriate patient preparation for cross-sectional imaging.
Angiography
;
methods
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Contrast Media
;
adverse effects
;
Drug-Related Side Effects and Adverse Reactions
;
Humans
;
Kidney Diseases
;
chemically induced
;
Tomography, X-Ray Computed
;
methods
8.Minimal fat renal angiomyolipoma with central scar and stellate calcification mimicking a calyceal calculus.
Eugene LOW ; Cher Heng TAN ; Bernard HO ; Simon CHONG
Singapore medical journal 2013;54(11):e221-3
Renal angiomyolipomas are benign neoplasms composed of varying amounts of adipose tissue, smooth muscles and blood vessels. They typically contain macroscopic fat, which is seen as negative attenuation on computed tomography. Calcification and scarring is rarely seen in renal angiomyolipomas. We report the case of a 40-year-old man who was found to have a renal angiomyolipoma with a central stellate scar and focal calcification. The lesion was initially misdiagnosed as a calyceal calculus.
Adipose Tissue
;
diagnostic imaging
;
pathology
;
Adult
;
Angiomyolipoma
;
diagnosis
;
surgery
;
Biopsy, Needle
;
Calcinosis
;
diagnostic imaging
;
pathology
;
Diagnosis, Differential
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Humans
;
Immunohistochemistry
;
Kidney Calculi
;
diagnosis
;
surgery
;
Kidney Calices
;
diagnostic imaging
;
pathology
;
Kidney Neoplasms
;
diagnosis
;
surgery
;
Low Back Pain
;
diagnosis
;
etiology
;
Male
;
Risk Assessment
;
Tomography, X-Ray Computed
;
methods
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Treatment Outcome
;
Urography
;
methods
9.A national trauma database analysis of alcohol- associated injuries.
Maxine Aiting LAM ; Su Xian LEE ; Kenneth Wei Jian HENG
Singapore medical journal 2019;60(4):202-209
INTRODUCTION:
Knowledge of the pattern of alcohol-associated injury (AAI) is lacking in Singapore. We aimed to determine the local demographic pattern, injury mechanism, injury severity and outcomes of AAI.
METHODS:
Data on trauma cases presenting to emergency departments in 2012-2013 was extracted from the National Trauma Registry. Cases with missing data fields and those aged 1-15 years were excluded. Patients were classified as alcohol positive (A+) or negative (A-) based on clinical assessment. The two groups' demographics, injury mechanism, injury severity, mortality and disposition were compared. Logistic regression analysis was used to determine independent associations with mortality.
RESULTS:
105,468 trauma cases met the inclusion criteria. 3.9% were A+ and their peak age range was 25-44 years. The A+ group had more Indian males (p < 0.001), and significantly more assaults, self-harm and falls (p < 0.001). Injuries in the A+ group were more common in public areas and less common in homes, recreational facilities and workplaces. Outcomes in the A+ group showed higher mean Injury Severity Score and mortality (p < 0.001). Significantly more A+ patients were admitted to hospital but had shorter mean length of stay (p < 0.001). Multivariate logistic regression revealed age > 44 years and male gender as independent predictors of mortality.
CONCLUSION
AAI in Singapore is associated with more severe injuries and resource utilisation. Using data from the registry, 'at risk' demographic groups are identified for targeted injury prevention. However, alcohol use is not an independent predictor of mortality in trauma cases.
10.Evaluation of non-contrast magnetic resonance imaging as an imaging surveillance tool for hepatocellular carcinoma in at-risk patients.
Jing Kai Joel LIU ; Chau Hung LEE ; Cher Heng TAN
Singapore medical journal 2022;63(4):203-208
INTRODUCTION:
This study aimed to evaluate the potential of non-contrast-enhanced magnetic resonance (MR) imaging as an imaging surveillance tool for detection of hepatocellular carcinoma (HCC) in at-risk patients and to compare the performance of non-contrast MR imaging with ultrasonography (US) as a screening modality for the same.
METHODS:
In this retrospective study, patients diagnosed with HCC between 1 January 2010 and 31 December 2015 were selected from our institution's cancer registry. Patients who underwent MR imaging and had US performed within three months of the MR imaging were included. For each MR imaging, two non-contrast MR imaging sequences - T2-weighted fat-saturated (T2-W FS) sequence and diffusion-weighted imaging (DWI) - were reviewed for the presence of suspicious lesions. A non-contrast MR image was considered positive if the lesion was seen on both sequences. The performance of non-contrast MR imaging was compared to that of hepatobiliary US for the detection of HCC.
RESULTS:
A total of 73 patients with 108 HCCs were evaluated. Sensitivity of non-contrast MR imaging for the detection of HCC using T2-W FS and DWI was 93.2%, which was significantly higher than that of US, which was 79.5% (p = 0.02). In a subgroup of 55 patients with imaging features of liver cirrhosis, the sensitivity of non-contrast MR imaging was 90.9%, which was also significantly higher than that of US, which was 74.5% (p = 0.02).
CONCLUSION
Our pilot study showed that non-contrast MR imaging, using a combination of T2-W FS and DWI, is a potential alternative to US as a screening tool for surveillance of patients at risk for HCC.
Carcinoma, Hepatocellular/pathology*
;
Contrast Media
;
Diffusion Magnetic Resonance Imaging/methods*
;
Gadolinium DTPA
;
Humans
;
Liver Neoplasms/pathology*
;
Magnetic Resonance Imaging/methods*
;
Pilot Projects
;
Retrospective Studies
;
Sensitivity and Specificity