No abstract available.
Hemodilution*

Hemodilution* ; Oxygen*

42 operated patients having mean blood losses of 476.67 (264.24ml have been applied for the normovolemic intensive hemodilution. The blood losses, the blood immediate miccer - hematocrites (Ht) were closely evaluated. The volume of blood immediate losses was well compensated with the infusion with a physiologic solution of NaCl 9‰ at 1.5 to 3 volumes as much as the one of blood losses, the blood transfusion was only done whenever the Ht reduced under 30%. All clinical and laboratory evaluations were well maintained before, during and after the operation. In comparison with 34 patients, in whom the volume of blood losses was compensated with the equal volume of homologous transfusion, there were no any differences between these two groups.
Blood ; Hemodilution

Anemia ; Hemodilution ; Humans ; Hypothermia

No abstract available.
Antibodies ; Hemodilution ; Humans ; Korea

BACKGROUND: Hemodilution reduces the concentration of clotting factors in blood and this may induce some degree of impairment of coagulation. But there are some evidence that hemodilution may induce a hypercoagulable state. The goal of this study is to investigate the changes of coagulation status during progressive hemodilution. METHODS: Whole Blood was diluted by 10% increment to 80% with 0.9% normal saline. At each 10% dilution blood coagulation status was analysed using thrombelastography (TEG) and was compared with that of an undiluted control specimen obtained concurrently from the same patients. RESULTS: Hemodilutions up to 40% decrease r and K times and increase values of MA and angle. Hemodilutions more than 70% increase r and K times and decrease values of MA and angle. CONCLUSIONS: Hemodilutions up to 40% increase coagulability and hemodilutions more than 70% decrease coagulability of whole blood in vitro.
Blood Coagulation ; Hemodilution* ; Humans ; Thrombelastography

Fifty three years old, healthy female patient had presented an acute severe anemia after intestinal bleeding within 2 days. She was hemodynamically stable even during extreme hemodilution with hemoglobin (Hb) below 3 g/dL. However, her condition deteriorated dramatically after Hb nearly 2 g/dL. The patient died solely of anemia at a hemoglobin concentration of 1.2 g/dL. We presumed the hemoglobin concentrations below 2 g/dL are maximally life-threatening; this is the terminal hemoglobin threshold that the hemoglobin concentration could be an independent predictor of death.
Anemia ; Female ; Hemodilution ; Hemoglobins ; Hemorrhage ; Humans

Brain Ischemia* ; Hemodilution* ; Intracranial Embolism ; Rabbits*

Since it's introduction by Hattersley in 1966, the acivated coagulation time(ACT) is widely used as a indicator of coagulation status of a patient during cardiac surgery. There have been many studies about the pre-heparin and post-heparin(post-protamine) ACT's, but the results vary. Comparisons of baseline ACT to postprotamine ACT revealed that there were studies which showed postprotamine ACT significantly above baseline ACT, while others were opposite. So we checked baseline ACT at three different point of time: 1) before anesthetic induction; 2) after anesthetic induction; 3) after sternotomy. We also checked postheparin and postprotamine ACT, and compared it with baseline ACTs. The postprotamine ACT showed significant increase compared with the preinduction and postinduction ACT and no significant differences between preheparin ACTs. We think that hemodilution and hypothermia might have influenced on the postprotamine ACT. It seems that baseline ACT can be measured anytime before the injection of heparin. But there are many factors which can influence the measurement of the ACT. Therefore, cares must be taken in the interpretating the result of ACT, considering the factors of ACT variability and clinical observations of blood coagulability.
Hemodilution ; Heparin ; Humans ; Hypothermia ; Sternotomy ; Thoracic Surgery*

BACKGROUND: This study was performed to investigate the clinical usefulness of combined autotransfusion using preoperative autologous donation(PAD) and acute normovolemic hemodilution(ANH) compared with autotransfusion using only PAD in 30 patients undergoing spinal surgery(posterior decompression and fusion). METHODS: Control group(n=15) were transfused with PAD(3 units), and received intra- and postoperative autotransfusion. Combined group(n=15) received ANH(2 units) in addition to above 3 methods applied to control group. Patients were not allowed to predonate or receive ANH if their Hct were below 34%. We applied induced hypotension only to the control group. RESULTS: There were no significant differences between groups in perioperative Hb and Hct levels. Mean volume of autologous blood salvaged by cell saver was significantly greater in combined group(710 ml) than in control group(288 ml). Besides autologous blood, 2.33 units(mean) of homologous blood were used postoperatively in 3 patients of control group and 2 units(mean) of predonated blood were unused and discarded in 3 patients of combined group. CONCLUSION: It appears that combined autotransfusion using PAD and ANH is useful and it increases success rate of autotransfusion.
Blood Transfusion, Autologous* ; Decompression ; Hemodilution* ; Humans ; Hypotension