From January 1997 to January 1998, there were 21 patients with chronic myelogenous leukemia who admitted to the Clinical Department, National Institute of Hematology and Blood Transfusion, B¹ch Mai Hospital. Mean age of patients was 42.85 for men and 38.12 for women. Among these patients, splenomegaly was observed in 100% of patients. Hyperleukocytosis, hyperthrombocytemia, erythrocytopenia, and hyperuricemia all were measured. 94% of patients were positive with Philadelphia chromosome
Leukemia ; Hydroxyurea ; Hematologic Agents ; diagnosis

No abstract available.
Anticoagulants ; Hematologic Agents ; Atrial Fibrillation

Invasive fungal disease (IFD) causes a high morbidity and mortality in patients with hematological malignancies. Reactivation of IFD after chemotherapy or hematopoietic stem cell transplantation (HSCT) is very common and associated with poor prognosis. Secondary antifungal prophylaxis (SAP) is effective in preventing IFD recurrence. With effective SAP, a history of IFD is not an absolute contraindication to allogeneic HSCT or continuation of high-dose chemotherapy. In recent years, a variety of antifungal drugs such as voriconazole, itraconazole, AmB and caspofungin have been found to be effective for SAP. However, its management during granulocytopenia and immunosuppression remains challenging. This review summarizes the current status of SAP in patients with hematological malignancies.
Antifungal Agents ; Hematologic Neoplasms ; Humans ; Immune Tolerance ; Immunosuppression ; Mycoses

Paraneoplastic cancer polyarthritis is a very rare manifestation of musculoskeletal disorders associated with several solid and hematologic malignancies. We describe a 71-year-old woman who presented initially with an abrupt onset of rheumatoid arthritis-like symmetrical polyarthritis. The patient was diagnosed with pancreatic cancer with multiple hepatic metastases approximately six months later. Her symptoms of polyarthritis improved after the introduction of medication including non-steroidal anti-inflammatory drugs and disease modifying anti-rheumatic drugs. This case suggests that a hidden malignancy should always be considered in elderly patients, who present with an abrupt onset of symmetric polyarthritis for the first time in their life.
Aged ; Antirheumatic Agents ; Arthritis ; Arthritis, Rheumatoid ; Female ; Hematologic Neoplasms ; Humans ; Neoplasm Metastasis ; Pancreatic Neoplasms ; Paraneoplastic Syndromes

Rhinocerebral mucormycosis (RCM) is an opportunistic, potentially life-threatening fungal disease. This infective disease invades not only the facial sinuses, but also the maxilla, zygoma, and rhino-cerebral structures with a massive destruction of the facial skeletons and soft tissue. This disease progresses within various underlying diseases, such as diabetes mellitus, hematologic malignancy, renal failure, and systemic immunodepression. The relationship between mucormycosis and these underlying conditions have been discussed extensively in the literature. The authors studied 6 cases of RCM diagnosed by a tissue biopsy and treated at the department of oral and maxillofacial surgery, from 1997 to 2012. Patients were treated with several kinds of surgical interventions and antifungal agents, and their clinical & radiological signs, underlying conditions, surgical methods, and outcomes were analyzed.
Antifungal Agents ; Biopsy ; Diabetes Mellitus ; Hematologic Neoplasms ; Humans ; Maxilla ; Mucormycosis* ; Renal Insufficiency ; Skeleton ; Surgery, Oral ; Zygoma

Systemic or disseminated candidiasis is a not uncommon serious complication among patients with impaired host-defense mechanisms, particularly among those with hematologic malignancies. Although widespread organ involvement is characteristic of disseminated candidiasis, there is only a few reports of skin manifestation in Korea. The diagnosis is often difficult to establish, since Candida organisms can be cultured from blood specimens in only 25% of the patients. Unless treated, the disease is rapidly fatal. If there is any evidence of respiratory distress or signs of sepsis in hematologic malignancy patients the possibility of systemic candidiasis and the need for parenteral antifungal therapy must be considered by early pathologic diagnosis of heralding skin lesions. We describe three hematologic malignancy patients with systemic candidiasis with disseminated maculopapules and vesicular eruption and respiratory distress. Skin biopsies showed multiple spores and pseudohyphae in the dermis and subcutis. These patients did not respond to intravenous antifungal agents and had fatal course.
Antifungal Agents ; Biopsy ; Candida ; Candidiasis* ; Dermis ; Diagnosis ; Hematologic Neoplasms* ; Humans ; Korea ; Sepsis ; Skin Manifestations* ; Skin* ; Spores

Antineoplastic Agents ; administration & dosage ; therapeutic use ; Hematologic Neoplasms ; drug therapy ; Humans

Anti-Infective Agents ; administration & dosage ; Clinical Competence ; Hematologic Diseases ; Hospitals, Special ; manpower ; Humans ; Medical Staff, Hospital

Antineoplastic Agents ; administration & dosage ; Drug Delivery Systems ; Genetic Therapy ; methods ; Hematologic Neoplasms ; drug therapy ; therapy ; Humans

Antibodies, Monoclonal ; therapeutic use ; Antineoplastic Agents ; therapeutic use ; Hematologic Neoplasms ; drug therapy ; Humans ; Liposomes