2.Echocardiographic diagnosis for ventricular non-compaction cardiomyopathy in foetus and the pathologically comparative study.
Jia ZHOU ; Leiqi TIAN ; Qichang ZHOU ; Shi ZENG ; Jiawei ZHOU ; Rongsen ZHANG ; Hai TONG
Journal of Central South University(Medical Sciences) 2015;40(7):754-759
OBJECTIVE:
To evaluate the echocardiographic diagnosis for ventricular non-compaction cardiomyopathy (NCCM) in foetus and to analyze the pathologic features of NCCM.
METHODS:
A total of 9 patients with fetal NCCM were examined by prenatal echocardiography from 2004 to 2013, which was compared with postnatal echocardiography or autopsy to analyze the fetal characteristic of myocardial ultrastructure.
RESULTS:
The results of echocardiography displayed an excessive muscle trabecular meshwork and muscle trabecular crypt, and the ventricular myocardium and non-compaction/compaction ratio was ≥2.0. Among the 9 fetuses of NCCM, 6 fetuses were involved in left ventricle, 2 in both left and right ventricles and 1 in right ventricle. Two fetuses were confirmed by postnatal echocardiography, the remaining 7 patients were chosen to terminate their pregnancies, which were confirmed by autopsy later. Muscle biopsies revealed the abnormal myocardial mitochondria, sarcomeres and myocardial fibrosis.
CONCLUSION
It is feasible to accurately diagnose NCCM by prenatal echocardiography. Fetal NCCM most often involves the left ventricle, but it can involve the right ventricle or both, too. The myocardial ultrastructure of fetal NCCM possesses certain unique characteristics, such as the low maturation of the mitochondria, sarcomeres and myocardial fibers.
Cardiomyopathies
;
diagnosis
;
Echocardiography
;
Fetus
;
Heart Ventricles
;
pathology
;
Humans
;
Myocardium
;
pathology
3.Neonatal gigantic rhabdomyoma of the left ventricle: a case report.
Xiao-Fei QIN ; Wan-Hai FU ; Chu-Ming YOU ; Yan-Yu CHEN
Chinese Journal of Contemporary Pediatrics 2009;11(12):1025-1026
Heart Neoplasms
;
pathology
;
Heart Ventricles
;
pathology
;
Humans
;
Infant, Newborn
;
Male
;
Rhabdomyoma
;
pathology
4.Huge right ventricular fetal type rhabdomyoma in infant--a case report.
Bao-hui GAO ; Li-wei XIE ; Zhi-guang ZHAO ; Zon-min WANG ; Sheng-li WANG
Chinese Journal of Pathology 2004;33(3):302-302
Female
;
Heart Neoplasms
;
pathology
;
Heart Ventricles
;
pathology
;
Humans
;
Infant
;
Rhabdomyoma
;
pathology
5.Assessment of Tricuspid Insufficiency and the Function of Right Ventricle Using Cardiac Magnetic Resonance Imaging Combined with Echocardiography.
Hui CHEN ; Yanling ZHAO ; Jianqun YU
Journal of Biomedical Engineering 2015;32(4):940-944
Right-sided cardiac valvular diseases have traditionally been considered less important than disease of mitral or aortic valve. However, severe tricuspid regurgitation could lead to right ventricle dysfunction and reduce patients' survival rate. In clinic setting, tricuspid valve disease should be paid more attention for patients with secondary tricuspid regurgitation caused by left-sided valvular surgery combined with irreversible annular dilatation increasing the risk of reoperation. In this review, we summarize the epidemiology, anatomy, pathology, diagnosis, ultrasound and cardiac magnetic resonance imaging findings in patients with tricuspid regurgitation.
Echocardiography
;
Heart
;
Heart Valve Diseases
;
diagnosis
;
Heart Ventricles
;
diagnostic imaging
;
pathology
;
Humans
;
Magnetic Resonance Imaging
6.Giant blood cyst tumor in the left ventricular outflow tract.
Chong ZHANG ; Jian HU ; Yi-Ming NI ; Zhi-Nong JIANG ; He-Yun XU
Chinese Medical Journal 2007;120(12):1109-1110
7.Left ventricular aneurysm with a calcified thrombus in the absence of chronic coronary artery occlusion.
Lei SU ; Hai-peng XIAO ; Juan ZHENG ; Wen HE
Chinese Medical Journal 2013;126(15):2997-2997
Adult
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Calcinosis
;
Heart Aneurysm
;
pathology
;
Heart Ventricles
;
Humans
;
Male
;
Thrombosis
;
pathology
8.Association between clinical features and histopathological findings in patients with left ventricular non-compaction cardiomyopathy.
Hong ZHAO ; Email: ZHAOHONGFW@ALIYUN.COM. ; Yang SUN ; Laifeng SONG ; Qingzhi WANG ; Yan CHU ; Jie HUANG ; Shengshou HU
Chinese Journal of Cardiology 2015;43(5):418-422
OBJECTIVETo investigate the association between clinical and histopathological features in patients with left ventricular non-compaction cardiomyopathy (LVNC).
METHODSHistopathological examinations were made on 11 LVNC recipient hearts from June 2004 to June 2014 in Fuwai Hospital, myocardial ultrastructure changes were detected using transmission electron microscopy. Association between clinical and pathological features were analyzed.
RESULTSPatients were (24 ± 11) years old. There were 6 patients with mucus matrix LVNC, 3 patients with fibrous fatty infiltration, and 2 patients with cardiomyocytes proliferation. The gross morphological changes of LVNC hearts were characterized by numerous and prominent trabeculations with deep intratrabecular recesses in left ventricular myocardium. Ratios of the thicker noncompacted endocardial layer (N) and thin epicardial compacted layer (C) (N/C ratio) were ≥ 2.0, and the most serious lesions were located in the left ventricular apex, and followed by the left ventricular free wall. Histological microscopic examinations evidenced numerous matrix-like material and immature cardiomyocytes on endocardial tissue. Transmission electron microscopy revealed mitochondrial abnormalities on morphology, number, and distribution, underdeveloped cardiomyocytes and anomalies of intercalated disc structure, increased deposition of extracellular matrix-like substance and perinuclear glycogen. Pathological changes on cytoplasmic matrix and intercalated disc were present in all three tissue types of LVNC in this cohort and mitochondria hyperplasia was detected in patients with fibrous fatty infiltration. Heart weight ≥ 350 g is often associated with increased number of mitochondria. Increased cytoplasmic matrix was often detected in patients with LVEF ≥ 30% while intercalated disc anomalies were often detected in patients with LVEF < 30%.
CONCLUSIONHistological changes were closely related clinical features in patients with LVNC.
Adolescent ; Adult ; Cardiomyopathies ; pathology ; Endocardium ; pathology ; Heart Ventricles ; pathology ; Humans ; Mitochondria, Heart ; pathology ; Myocardium ; pathology ; ultrastructure ; Young Adult
9.Two cases of ventricular noncompaction myocardium with preexcitation syndrome.
Zhao-kui ZHANG ; Ju-lan MA ; Ying-lu LI
Chinese Journal of Cardiology 2008;36(5):465-465
Adult
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Child, Preschool
;
Heart Ventricles
;
pathology
;
Humans
;
Male
;
Myocardium
;
pathology
;
Pre-Excitation Syndromes
;
etiology
;
pathology
10.Author Reply.
Yonsei Medical Journal 2005;46(2):310-312
No abstract available.
Echocardiography
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Heart Defects, Congenital/*diagnosis/pathology
;
Heart Ventricles
;
Humans
;
Magnetic Resonance Imaging
;
Tomography, X-Ray Computed