Coronary Disease ; Humans ; Smoking

With the development of the dialysis technology,the survival time of patients with chronic renal failure is prolonged,while more complications which affect the quality of life or even threat the life of patients are followed.Secondary hyperparathyroidism(SHPT)with a certain incidence and mortality is one of the common complications,and its main characteristic performances ale hyperphosphatemia,hypocalcemia and high level of parathyroid hormone.Most patients Can be cured by the treatment of medicine while surgical treatment is still required by some cases in which the disorder of the parathyroid function can not be well regulated through medicine treatment.The purpose of this paper is to make a review of the recent studies of surgical treatment in patients with SHPT.

Toll-like receptors is a super-family of pathogen recognition-receptors discovered in recent years.During the process of ischemia-reperfusion, the Toll-like receptor 4 (TLR4) combines with lipopolysaccharide and many endogenous ligands such as high mobility group protein B1, heparan sulfate, and fibrinogen. Through the myeloid differentiation protein 88 -dependent and -independent signaling pathways, the products induce the release of inflammatory cytokine-mediated inflammatory response, leading to injuries. ω-3 polyunsaturated fatty acids, by inhibiting the signal pathway activation and target gene expression of TLR4, can influence the function of many immune cells and regulate the body's inflammatory response and immune function. This article reviews the function of TLR4 during ischemia-reperfusion injury and the possible interventional role of ω-3 polyunsaturated fatty acids.

Objective: To investigate the expression of the transcription factor GATA-4 in human heart development.Methods: Immunohistochemistry was used to detect the expression of GATA-4 in 45 normal human embryonic hearts of 6-23 gestational weeks.Results: In the early stage of the fetal heart morphogenesis,we observed no GATA-4 expression in the ventricle,weak expression in the atria and relatively high expression in the trabecular nets.With the heart development,the GATA-4 expression was enhanced in the atria,ventricle,trabecular nets and atrial-ventricular valves,as well as in the muscular and membranous interventricular septum,the highest in each part of the heart.Conclusion: The transcription factor GATA-4 plays an important role in human heart development.

With the development of chemical analysis technology and data processing technology,metabonomics has become the important method in functional genomics study.In this paper,the definition and advangtages of metabonomics are provided.The implication of metabolomics in pharmacology are summarized and future perspectives are discussed.

This year an outbreak of influenza in Mexico comes from a new epidemic of influenza viruses:A/H1N1 influenza virus.This virus is a kind of virus mixture,including human,avian and swine influenza virus gene fragments.The pathogenic mechanism of avian,swine and human influenza virus in its natural host were compared.The main purpose is to assess the risk of which pigs and poultry has the possibility to become one of zoonotic disease and to assess the possible role in process of avian flu transmission from pigs to people.As zoonotic disease,avian influenza and swine influenza virus have the key role in the process of human infection.But the influenza virus spread of crossing species barrier is not sufficient to cause a large outbreak of human influenza.Animal influenza viruses must have a significant genetic variation before they could live for a long term in the crowd.

Objective To generalize widely the use of laboratory electronic order system in hospital,and rebuild and optimize laboratory workflow. Methods The workflows were confirmed by step-by-step and deployed synthetically materials preparation and staff training,which improved the system continuously during its working. Results All the concerned modules runs stably,which functions are improved greatly and the expected goals of design and application generalization are reached. Conclusion The functional applicability and manipulability of interface are in favor of generalizing the use of the health information system.

The portable high frequency (HF) X-ray machine for field use is introduced in this paper, which applies HF technology and the microcomputer. Compared with the traditional one, it has many new functions such as the self-motion exposal, real-time inspection and display, the alarm of the failure and the automatic disposal. With the advanced technology, it has overcome the deficiencies of the traditional one, including the overweight, bulkiness and unportability. Equipped with the portable mobile shelf, this machine is fit for field operations.

Objective To evaluate the relationship between ischemic cerebrovascular desease(ICVD) and carotid atherosclerosis and its risk factors.Methods 186 cases with ICVD and 194 cases without cerebrovascular disease or healthy people(control group) were enrolled in this study.Carotid ultrasonagraphy was performed in the two groups and blood biochemical indexes were detected in the meanwhile.The data were compared between the two groups.Results Higher age(69?7years) and higher prevalence of hypertension(66.1%),diabets mellitus(53.4%) and metabolic syndrome(44.6%) were found in ICVD group than in control groups [(61?5)years,48.8%,15.2%,12.9%](all(P