Objective To study the results from Cutting balloon for stiff and uncompliant coronary lesion. Methods Thirty-three patients with coronary artery disease underwent conventional coronaryangioplasty with high pressure balloon. Cutting balloon was used for those lesions after they failed in high pressure balloon angioplasty. Results The total success rate for cutting balloon for stiff and uncompliant lesion was 87.9%. We got remarkable results from cutting balloon (MLD 2.47?0.54 mm; DS 16%?15%) with less dilation pressure and dilation time (8.93?1.23 atm; 1.65?0.44 min). Conclusion Our results show that cutting balloon can be used in the stiff lesion and some calcified lesion which was once considered to be contraindiction it could be a high procedural successful rate and very safe with less complications compared with other kinds of new technology.