1.Fungal Genotyping – Current Clinical Application
Malaysian Journal of Medical Sciences 2014;21(6):1-2
The emergence of fungal species as opportunistic pathogens has warranted further studies on their pathogenicity, epidemiology, and transmissibility. Fungal genotyping has been employed to study the genetic relatedness within the organism, in order to obtain answers to epidemiological questions (such as in outbreak confirmation) as well as to provide basis for the improvement for patients care. Various fungal genotyping methods have been previously published, which can be chosen depending on the intended use and the capability of individual laboratory.
2.Laryngeal mask airway (LMA-ProSeal™) malfunction causing acute airway obstruction
Binu Puthur SIMON ; Syed Harun HABIBULLAH
Brunei International Medical Journal 2012;8(4):205-209
The Laryngeal Mask Airway ProSeal™ (LMA-ProSeal™; Laryngeal Mask Company Limited) is a reusable supraglottic airway device developed to enhance supraglottic airway protection and extend the benefits of the classic LMA (Laryngeal Mask Airway) to greater number of patients. Added features include an additional drain tube to channel fluid away from the airway and a tighter seal against the glottic opening with no increase in mucosal pressure. Clinicians have extended the use of the LMA-ProSeal™ inside and outside the operating theatre including use for difficult airway management and airway rescue. However, even these new devices have their limitations. We report an unforeseen acute airway obstruction caused by LMA-ProSeal™ malfunction during ophthalmic surgery. The cuff of the device was deformed with herniation to one side upon insufflation of the balloon.
Laryngeal Masks
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Equipment Failure
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Complications
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Percutaneous Coronary Intervention
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Stents
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Thrombosis
3.An Assessment of the Movement and Function of Children with Specific Learning Disabilities: A Review of Five Standardised Assessment Tools
Nur Sakinah Baharudin ; Dzalani Harun ; Masne Kadar
Malaysian Journal of Medical Sciences 2020;27(2):21-36
ract
Various standardised assessment tools have been used to evaluate children with
disabilities. However, assessment tools that provide information on the movement and function
of children with specific learning disabilities (SLD) are still limited. This article provides a
narrative review of the characteristics of five movement and/or function assessment tools. The
strengths and limitations of the tools will be highlighted. Empirical studies on the assessment tools
used are reviewed based on three criteria: (i) standardised tools; (ii) assessment of movement
and/or function; (iii) applicability to children with SLD ranging from 4–17 years of age and
widely used in practice. The following instruments have been included as they have been found
to fulfil the criteria: (i) the Bruininks-Oseretsky test of motor proficiency-2 (BOT-2); (ii) the
movement assessment battery for children-2 (MABC-2); (iii) the pediatric balance scale (PBS);
(iv) the Vineland adaptive behaviour scale-II (VABS-II) and (v) the pediatric evaluation of disability
inventory-computerised adaptive test (PEDI-CAT). The article presents the characteristics,
strengths and limitations of five standardised assessment tools that are currently in use, which
measure the movement and/or function of children with SLD. This article concludes with a
discussion of recommendations for the best approaches to evaluating the movement and functional
abilities of children with SLD.
4.Effects of Plateau Time on Cervical Vestibular Evoked Myogenic Potential (cVEMP) elicited by 500-Hz Tone Burst
Vijay Marimuthu ; Mohd Fairul Syafiq Harun
Malaysian Journal of Health Sciences 2016;14(1):31-36
Cervical Vestibular Evoked Myogenic Potential (cVEMP) is a routine vestibular test which checks the integrity of
vestibulocollic reflex (VCR) pathway. Clinically, 500-Hz tone burst is widely used stimulus to evoke a cVEMP. Although
several studies have suggested different plateau times (PT) for eliciting cVEMPs, but not many have reported the optimal
PT for evoking cVEMP using 500 Hz tone burst stimuli. Therefore, the present study aimed to investigate the effect of
PT on cVEMPs elicited by 500 Hz tone burst at 95 dBnHL using four different PT (0, 2, 4 and 10 ms). Thirty healthy
adults with normal hearing and vestibular systems participated in this study. Results revealed that the P1 latency was
significantly longer for PT 10 ms compared to other PTs. N1 latency was significantly prolonged for long PT of 10 ms
compared to PT 2 ms. P2 latency showed no significant differences among PTs. The P1-N1 inter-amplitude values
however revealed no significant difference across all PTs. It was found that the P1-N1 inter-amplitude was severely
affected after 4 ms of PT. This study concluded that the PT of either 0 or 2 ms yielded the most robust cVEMP.
Vestibular Evoked Myogenic Potentials
5.Metastatic mucinous carcinoma of the eyelid.
Gurjeet Kaur ; Rosli Ismail ; Hairulhasliza Harun
The Malaysian journal of pathology 2005;27(2):117-8
Metastatic eyelid tumours are rare and account for less than 2% of all eyelid neoplasms. We report a case of metastatic breast carcinoma to the eyelid in a 60-year-old Chinese lady presenting with a 2-year history of enlarging, painless nodular lower eyelid swelling. The 1 cm diameter lesion was provisionally diagnosed as a sebaceous cyst. However the excision biopsy revealed a mucinous carcinoma expressing oestrogen receptor protein. She had a past history of mastectomy one year previously and histology showed an infiltrating ductal carcinoma (oestrogen receptor status negative) without evidence of axillary lymph node metastasis. She had completed adjuvant radio- and chemotherapy. Further treatment of the current lesion involved a wide excision which did not show any residual malignancy. She had no other evidence of metastasis and was treated with letrozol. We highlight this case to create awareness among clinicians and opthalmologists on the possibility of metastatic disease as a cause of eyelid swelling, especially in patients with a history of cancer. It may also be the first sign of metastatic disease of an internal malignancy. A review of the literature is also presented.
Eyelids
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Metastatic to
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Neoplasm Metastasis
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Carcinoma
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brief historical notes, excludes case histories
6.Non-specific skin purpura
Mohd Shaiful Ehsan Shalihin ; Zulkifli Harun ; Iskandar Firzada Osman
Malaysian Family Physician 2018;13(2):39-41
Essential thrombocythemia is one of the myeloproliferative neoplasms. Palpable purpura is
a rare manifestation that may delay diagnosis and treatment. We report a case of essential
thrombocythemia in a 50-year-old man, who presented with recurrent thigh pain for the past one
year with nonspecific localized purpura. His full blood count revealed isolated thrombocytosis of
880,000/µL with an impression of myeloproliferative disorder from peripheral blood film. He
was referred urgently to the hematology team, which proceeded with a venesection. His condition
improved with hydroxyurea. This was a rare case of chronic presentation of myeloproliferative
neoplasm detected at a primary care clinic
7.Insulin therapy refusal among type II diabetes mellitus patients in Kubang Pasu district, the state of Kedah, Malaysia.
Wei Leong TAN ; Siti Fairus ASAHAR ; Noor Liani HARUN
Singapore medical journal 2015;56(4):224-227
INTRODUCTIONDiabetes mellitus is a rising non-communicable disease in Malaysia. Insulin therapy refusal is a great challenge for healthcare providers, as it results in delayed insulin initiation. This study was conducted to determine the prevalence of insulin therapy refusal and its associated factors.
METHODSThis cross sectional study was conducted at seven public health clinics in Kubang Pasu district, Malaysia, from March to October 2012. A newly developed and validated questionnaire was used and participants were selected via systematic random sampling. Only patients diagnosed with type II diabetes mellitus (T2DM) and under the public health clinic care in Kubang Pasu were included in the study. Multiple logistic regressions were used to study the association between insulin therapy refusal and its associated factors.
RESULTSThere were 461 respondents and the response rate was 100%. Among these 461 patients with T2DM, 74.2% refused insulin therapy. The most common reason given for refusal was a lack of confidence in insulin injection (85.4%). Multiple logistic regression revealed that respondents who had secondary education were 55.0% less likely to refuse insulin therapy than those who had primary or no formal education (p = 0.009, adjusted odds ratio [OR] = 0.45, 95% confidence interval [CI] = 0.25-0.82). There was also a significant inverse association between glycated haemoglobin (HbA1c) and insulin therapy refusal (p = 0.047, adjusted OR = 0.87, 95% CI = 0.76-1.00).
CONCLUSIONInsulin therapy refusal is common in Kubang Pasu. Education status and HbA1c should be taken into consideration when counselling patients on insulin therapy initiation.
Adult ; Aged ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 ; blood ; drug therapy ; epidemiology ; Female ; Follow-Up Studies ; Glycated Hemoglobin A ; metabolism ; Humans ; Hypoglycemic Agents ; therapeutic use ; Insulin ; therapeutic use ; Malaysia ; epidemiology ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Surveys and Questionnaires ; Young Adult
8.Inflammatory Pseudotumour of Skull Base – Diagnostic Challenge and Treatment Outcome
Kahairi Abdullah ; Ahmad Raja Lope ; Wan Ishlah Leman ; Norra Harun
The Medical Journal of Malaysia 2012;67(5):526-528
We report a case of an inflammatory pseudotumour (IP)
involving the floor of the skull base, which demonstrated
aggressive behavior both clinically and radiologically. In this case, the diagnosis was established by clinical presentation, magnetic resonance imaging (MRI), histopathological examination (HPE) and the dramatic response towards high dose steroid therapy. The clinical features improved with oral cyclophosphamide in combination with oral steroid, which were given for a period of three months.
9.Risk factors and outcomes of imipenem-resistant Acinetobacter bloodstream infection in North-eastern Malaysia
Deris Zainy Zakuan ; Shafei Nazri Mohd ; Harun Azian
Asian Pacific Journal of Tropical Biomedicine 2011;(4):313-315
Objective: To determine the risk factors and outcomes of imipenem-resistant Acinetobacterbaumannii (IRAB) bloodstream infection (BSI) cases, since there is very little publication on Acinetobacter baumannii infections from Malaysia. Methods: A cross sectional study of 41 cases (73.2%) of imipenem-sensitive Acinetobacter baumanii (ISAB) and 15 cases (26.8%) of IRAB was conducted in a teaching hospital which was located at North-Eastern state of Malaysia. Results:There was no independent risk factor for IRAB BSI identified but IRAB BSI was significantly associated with longer bacteraemic days [OR 1.23 (95% CI 1.01, 1.50)]. Although prior use of carbepenems and cephalosporin were higher among IRAB than ISAB group, statistically they were not significant. There was no significant difference in term of outcomes between the two groups. Conclusions: Although statistically not significant, this analysis compliments previous publication highlighting the importance of appropriate empiric antibiotic usage in hospital especially carbepenems and need further evaluation with bigger subjects.
10.An Observational Study of Blood Glucose Levels during Admission and 24 Hours Post-Operation in a Sample of Patients with Traumatic Injury in a Hospital in Kuala Lumpur
Rahmat Harun @ Haron ; Musa Kamarul Imran ; Mohammed Saffari Mohammed Haspani
Malaysian Journal of Medical Sciences 2011;18(4):69-77
Background: Traumatic brain injury (TBI) has been associated with an acute stress response mediated by the sympathoadrenomedullary axis, which can be assessed by measuring blood glucose level.
Methods: This prospective observational study was conducted for a year in 2007 among 294 patients who had been treated for TBI in Hospital Kuala Lumpur. Patients fulfilling the set criteria were recruited into the study and data, including blood glucose level and Glasgow Outcome Score at 3-month follow-up, were collected.
Results: 294 patients were included in the study: 50 females (17.0%) and 244 males (83.0%). The majority of cases were young adult patients (mean age of 34.2 years, SD 13.0). The mean blood glucose level during admission and post-surgery were 6.26 mmol/L (SD 1.30, n = 294) and 6.66 mmol/L (SD 1.44, n = 261), respectively. Specifically, the mean admission glucose level associated with mild TBI was 5.04 mmol/L (SD 0.71); moderate TBI, 5.78 mmol/L (SD 1.02); and severe TBI, 7.04 mmol/L (SD 1.18). The mean admission glucose level associated with a poor outcome in patients with isolated TBI was 6.98 mmol/L (SD 1.21). Patients with admission glucose of 5.56 mmol/L (SD 1.21) were more likely to have a favourable outcome.
Conclusion: Mild, moderate, and severe TBI were associated with an increase in blood glucose levels during admission, and the mean increase in glucose levels is based on the severity of the isolated TBI. Surgical intervention did not cause further significant changes in blood glucose levels. Patients with isolated TBI and minimal increases in blood glucose levels were more likely to have a favourable outcome.