Objective Cardiac resynchronization therapy(CRT) by simultaneous biventricular pacing improves left ventricular systolic synchrony in patients with dilated cardiomyopathy(DCM). Tissue synchronization imaging(TSI) technique was used to evaluate the impact of sequential CRT with individualized interventricular delay programming.Methods TSI was carried out in five patients with DCM and left bundle branch block before and one day after pacemaker implantation in four chamber view,two chamber view and apical long aixs view and in two patients with DCM before pacemaker implantation.Results Three patients with DCM showed that left ventricular asynchrony was improved afetr CRT,but two patients with DCM showed left ventricular asynchrony was not improved after CRT.CRT was not performed in one patient with DCM due to ventricular systolic resynchronization,one patient with DCM did not have CRT because LVEF was 42%.Conclusions TSI is useful in predicting and evaluating the effect of CRT in the patients with DCM.

The aryl hydrocarbon receptor(AhR),also known as dioxin receptor,is a ligand-dependent transcription factor.Because of its important role in occurrence and development of cancer,it has been widely studied.AhR is now considered to be an important regulator of host-environment interactions in immune and inflammatory responses and is involved in pathogenesis of many skin diseases.Because AhR is highly expressed in all types of skin cells and regulates many genes that are critical to skin function,it has the potential to be a new target for the treatment of inflammatory skin diseases.This paper presents and analyzes research findings on the relationship between AhR and inflammatory skin diseases to help accelerate the development of new drugs.

Urinary tract infection (UTI) is one of the most common infectious diseases. It has the characteristics of high recurrence rate and prolonged course. At present, the problem of antibiotic resistance is becoming more and more serious, the incidence of adverse reactions is high, and the disadvantages of long-term administration appear, which brings severe challenges to the treatment of recurrent urinary tract infection. The prevention and treatment of UTI recurrence has become the focus of research. Recurrent urinary tract infection is related to the immune regulation mechanism of the body. Administration of immune regulation can provide new ideas for prevention and treatment. The vaccine based on immune regulation to prevent rUTI has made some progress. It can not only reduce the frequency of recurrences, but also decrease related symptoms. At the same time, the vaccine has good tolerance, high safety and good application prospect. This paper aims to summarize the progress of immune regulation and immune vaccines in vivo and clinical research.