1.The expression and significance of cyclooxygenase-2 in primary and recurrent astrocytoma
Fei WANG ; Yan XUE ; Haoqing SONG ; Tingjian YANG ; He ZHANG ; Wei LIU ; Bing LIU
Chinese Journal of Postgraduates of Medicine 2014;37(8):14-16
Objective To observe the expression of cyclooxygenase(COX)-2 in different malignancy astrocytoma by immunohistochemistry,so as to judge the invasive action of COX-2 in astrocytoma.Methods A total of 55 cases with astrocytoma underwent 63 times operation including 8 recurrent cases were selected,and 9 cases with severe brain injury who needed decompression surgery were selected as control group.The astrocytoma tissues and decompression surgery to remove tissues removed immediately fixed in 10% formalin buffer solution.The expression of COX-2 was determined by immunohistochemistry.Results The positive expression rate of COX-2 in astrocytoma tissues was higher than that in decompression surgery to remove tissues[69.84% (44/63) vs.1/9],and there was significant difference (x2 =11.589,P < 0.01).The positive expression rate of COX-2 in recurrent astrocytoma tissues was higher than that in primmy astrocytoma tissues [8/8 vs.65.45% (36/55)],and there was significant difference (x2 =3.957,P < 0.05).With increased astrocytoma malignancy,the positive expression rate of COX-2 also increased,and there was significant difference (P < 0.05).Conclusion COX-2 may have some relationship with the invasion of astrocytoma,leading to increase tumor grade,and relapse.