1.Hospital Infection after Hemopoietic Stem Cell Transplantation:Clinical Analysis of 21 Cases
Ling ZHANG ; Zhenchuan SHANG ; Chunrong SU ; Haoping SUN
Chinese Journal of Nosocomiology 2005;0(11):-
OBJECTIVE To study the rate and the risk factors of hospital infection after hemopoietic stem cell transplantation and improve treatment strategy.METHODS The clinical data of 21 cases of hemopoietic stem cell transplantation were analyzed respectively in our hospital.RESULTS Hospital infection was found in 15 cases,the infection rate was 71.4%.Fifteen kinds of bacteria and 4 kinds of fungi were observed.The risk factors were aggressive operation,the abuse of glucocorticoid and antibiotics.CONCLUSIONS The patients have a high rate of hospital infection after hemopoietic stem cell transplantation and a poor prognosis because of hospital infection.To decrease the rate of hospital infection after hemopoietic stem cell transplantation,the whole environmental protection should be carried out except decreased aggressive operation and the correct use of glucocorticoid and antibiotics.
2.Clinical significance of diffusely increased 18F-FDG uptake in the thyroid
Ge ZHAI ; Biao LI ; Miao ZHANG ; Haoping XU ; Chao WANG ; Guizhi GE ; Chenwei SUN ; Chenmo ZHU
Chinese Journal of Endocrinology and Metabolism 2009;25(4):418-419
lymphocytic thyroiditis.
3.Correlation of imbalance of urinary exosome Th1/Th2 with diabetic nephropathy
Aili SUN ; Yihong NI ; Guangju GUAN ; Haoping DENG ; Yuantao LIU ; Shihong CHEN ; Fudun SUN ; Xianghua ZHUANG ; Xiaoyan HU ; Jingti DENG
Chinese Journal of Nephrology 2011;27(9):637-640
Objective To examine the correlation of imbalance of urinary exosome Th1/Th2 with diabetic nephropathy (DN).Methods A total of 120 patients with type 2 diabetes mellitus (DM) and 30 healthy volunteers as control were enrolled in the study.According to urinary albumin/creatinine ratio (UACR),type 2 diabetes mellitus patients were divided into 3 groups:diabetes mellitus without nepbropathy group (DM,n=40,UACR<30 mg/gCr),microalbuminuria group (DN 1,n=50,UACR-30~300 mg/gCr) and clinicoalbuminuria group (DN 2,n=30,UACR>300 mg/gCr).Urine exosome-interferon-gamma (IFN-γ) and exosome-interleukin 4 (IL-4) levels were determined by enzyme-linked immunosorbent assay (ELISA).Multiple stepwise linear regression was used to analyze the correlation of exosome-IFN-γ/IL-4 with glycated hemoglobin (HbA1c),cholesterol (CH),UACR,Scr and BUN.Results Th1/Th2 ratio in DM,DN1,DN2 groups was significantly higher than that in healthy group (0.8089±0.2458,0.8993 ±0.3515,0.8571±0.2470 vs 0.6198±0.1769,all P<0.01).Correlation analysis showed that urinary exosomeIFN-γ/IL-4 ratio was positively correlated with UACR (r=0.213,P=0.015) and BUN (r=0.292,P=0.001).Multiple stepwise linear regression analysis showed that BUN was independent determinants for exosome-IFN-γ/IL-4 (β=0.246,P=0.006).Conclusion The imbalance of urinary exosomeTh1/Th2 is correlated with DN,which may play an important role in the pathogenesis of DN.