1.Effect of antibiotics combined with surgical treatment and psychological intervention on congenital heart disease complicated with infective endocarditis
Shuqun HUANG ; Haofeng CEN ; Youyi SUN
Chinese Journal of Biochemical Pharmaceutics 2017;37(5):435-437
Objective To investigate the clinical treatment of congenital heart disease complicated with infective endocarditis effective programs, joint analysis of the clinical efficacy of the use of antibiotics in surgery on the basis of providing a basis for clinical treatment.MethodsAnalysis of January 2009 to December 2016 in our hospital with congenital heart disease complicated with infective endocarditis clinical data of 78 cases of patients were randomly divided into observation group and control group of 39 cases, The control group was given appropriate antimicrobial treatment, patients in the observation group according to the samples of culture and drug sensitivity test choose appropriate broad-spectrum antibiotics for treatment, observation after treatment and the clinical efficacy of the two groups were analyzed.According to the medical staff were given psychological psychological counseling for patients to explain the importance of disease related knowledge and related treatment, timely eliminate / alleviate the negative emotion of patients with, to ensure that patients with a good attitude to face treatment.Results78 cases of congenital heart disease complicated with infective endocarditis clinical infection germs mainly Staphylococcus aureus and Streptococcus viridans, in addition to a small number of patients infected with Enterococcus faecalis, Staphylococcus epidermidis, gram-negative bacteria and mixed bacteria.Two groups of patients after treatment statistical clinical efficacy results show 56.41% cure rate in patients in the observation group, the effective rate was 97.43% clinical cure rate was 35.90% in the control group of patients, clinical effective rate was 79.49%, a statistically significant difference between groups (P<0.05).Statistical quality of life of patients after two scores, statistics of daily living, psychological feelings, general health, drug dependence and pain and discomfort five indicators, pain and discomfort, and two indicators of the overall health of patients in the observation group was significantly better than the control group (P<0.05), no significant difference.ConclusionThe clinical administration congenital heart infection endocarditis surgical treatment of broad-spectrum antibiotics combined with substantial clinical efficacy, safety, reliability, patients were recovering well, can be clinical.
2.Comparison of the effect of full thoracoscopic lobectomy and thoracotomy in the treatment of non -small cell lung cancer
Haofeng CEN ; Yong MAO ; Sheng ZHAO
Chinese Journal of Primary Medicine and Pharmacy 2016;(1):15-17
Objective To study the clinical efficacy of full thoracoscopic lobectomy and thoracotomy in treat-ment of non -small cell lung cancer.Methods 200 patients with non -small cell lung cancer were divided into group A and group B according to the different surgical methods,with 100 cases in each group.Group A was given the full treatment thoracoscopic lobectomy,group B was received treatment thoracotomy.Pain situation were evaluated in visual analog scale(VAS)method,clinical efficacy and adverse reactions of the two groups were compared.Results The intraoperative blood loss,operative time,drainage,VAS scores and hospital stay of group A were (253.4 ± 1.9)mL,(181.3 ±9.3)min,(174.6 ±4.2)mL,(4.2 ±1.4)points and (7.2 ±0.6)d respectively,which were significantly better than (409.3 ±2.4)mL,(232.2 ±3.2)min,(312.9 ±2.5)mL,(6.3 ±0.9)points and (13.5 ± 0.6)d of group B,the differences were statistically significant(t =8.928,9.028,8.232,9.701,10.906,all P <0.05).The lymph node metastasis number and the number of lymph node dissection of the two groups had no statistically significant differences(t =2.098,3.092,2.983,all P >0.05).The incidence of complications of group A were significantly lower than those of group B,the difference was statistically significant(χ2 =9.033,P =0.002). Conclusion Full thoracoscopic lobectomy in the treatment of non -small cell lung cancer has better effect compared with thoracotomy,its harm to patients is small,and has fewer postoperative complications.
3.Clinical study on acute respiratory distress syndrome in severe thoracic trauma
Biao WU ; Xiaodong YUAN ; Haofeng CEN ; Yun CAI
China Modern Doctor 2015;(16):36-38,41
Objective To investigate the diagnosis and treatment method of acute respiratory distress syndrome (ARDS) caused by severe chest traumain. Methods Complicated 89 cases in our hospital from July 2007 to February 2015 with severe chest trauma in patients, among which 21 cases with acute respiratory distress syndrome (ARDS), the diagnosis, treatment were analyzed and summarized. Through the comparison of oxygen partial pressure (PaO2), partial pressure of carbon dioxide (PaCO2), oxygen index (PaO2/FiO2) before and after treatment, and were given thepatients to maintain respiratory tract unobstructed, through compared the change patient vital signs to value treatment effect evaluation. Results After treatment, PaO2 increased, PaCO2 decreased, PaO2/FiO2 increased significantly, there were significant differences compared with those before the treatment (P<0.05); in 21 cases, 6 cases were complicated with pneumonia appears, and they were recovered after symptomatic treatment; of which 2 cases died, 1 case of death due to excessive blood loss, also 1 case gave up the treatment. Conclusion Early detection and early treatment of ARDS is significant prognostic, in the course of treatment, reasonable and correct use of breathing machine is effect measure to improve the success rate of treatment.