Objective To find out the endoscopic characteristics of peptic ulcer disease in minority area. Methods Analysis of 28 547 endoscopic cases in Yanbian area during 1990－ 1998. Results In all endoscopic cases,4 348 cases(15.23％ ) of peptic ulcer were found.Among them,48.22％ (2 097cases) were of duodenal ulcer,44.18％ (1 921 cases) of gastric ulcer, and the rest 7.59％ (330 cases) of complex ulcer. Among these cases,male and female patients were 2 974(19.05％ ) and 1374(10.62％ ) respectively. The positive detective rates between male and female patients have significant difference(P0.01). Conclusion It suggested that the positive detective rate of peptic ulcer in Han nationality was higher than that in Korea nationality at Yanbian area; and, the male patient were more than the female ones.

Objective To investigate the diagnosis and treatment method of acute respiratory distress syndrome (ARDS) caused by severe chest traumain. Methods Complicated 89 cases in our hospital from July 2007 to February 2015 with severe chest trauma in patients, among which 21 cases with acute respiratory distress syndrome (ARDS), the diagnosis, treatment were analyzed and summarized. Through the comparison of oxygen partial pressure (PaO2), partial pressure of carbon dioxide (PaCO2), oxygen index (PaO2/FiO2) before and after treatment, and were given thepatients to maintain respiratory tract unobstructed, through compared the change patient vital signs to value treatment effect evaluation. Results After treatment, PaO2 increased, PaCO2 decreased, PaO2/FiO2 increased significantly, there were significant differences compared with those before the treatment (P<0.05); in 21 cases, 6 cases were complicated with pneumonia appears, and they were recovered after symptomatic treatment; of which 2 cases died, 1 case of death due to excessive blood loss, also 1 case gave up the treatment. Conclusion Early detection and early treatment of ARDS is significant prognostic, in the course of treatment, reasonable and correct use of breathing machine is effect measure to improve the success rate of treatment.

ObjectiveTo explore the therapeutic effect and mechanism of Xianglian Huazhuo prescription on chronic atrophic gastritis （CAG） in rats based on the Hedgehog signaling pathway. MethodsThe CAG rat model was established by sodium salicylate， N-methyl-N′-nitro-N-nitroguanidine （MNNG）， and irregular feeding. The successfully modeled rats were randomly divided into a model group （180 mg·L^-1）， a moradan group （1.4 g·kg^-1）， and Xianglian Huazhuo Prescription groups with high， medium， and low doses （36， 9， 18 g·kg^-1）， followed by drug intervention. Hematoxylin-eosin （HE） staining was used to observe morphological changes in the gastric mucosa. Transmission electron microscopy was used to observe the ultrastructure of gastric mucosa cells. Real-time quantitative polymerase chain reaction （Real-time PCR） was used to detect the mRNA expression of Sonic Hedgehog （Shh）， Patched 1 （Ptch1）， and Glioma-associated oncogene homolog 1 （Gli1）. Western blot was used to detect the protein expression levels of Shh， Ptch1， and Gli1 in the gastric mucosa. Immunohistochemistry was used to observe the protein expression of the epithelial marker E-cadherin. ResultsCompared with the normal group， the CAG model group showed a reduction in gastric mucosal intrinsic glands and infiltration of inflammatory cells. The ultrastructure of gastric mucosal cells showed nuclear pyknosis， fewer mitochondria， and abnormal mitochondrial structure. The mRNA and protein expression of Shh， Ptch1， and Gli1 in the gastric mucosa were significantly decreased （P<0.05）， and E-cadherin protein expression was decreased. Compared with the model group， the intervention groups showed varying degrees of improvement in histopathological morphology and cellular ultrastructure. The mRNA and protein expression of Shh， Ptch1， Gli1， and E-cadherin increased to varying degrees. Xianglian Huazhuo Prescription upregulated the expression of key Hedgehog pathway factors and E-cadherin at both the mRNA and protein levels （P<0.05）. ConclusionXianglian Huazhuo prescription has a therapeutic effect on CAG in rats， and its mechanism may be related to activation of the Hedgehog signaling pathway and inhibition of epithelial-mesenchymal transition （EMT）.