0.05).Incidence rate of leukopenia in the high dose DDP group was significantly higher than in the low dose DDP group(87.5% vs.71.6%)(P0.05).CONCLUSION:The therapeutic effects of high dose DDP and LD-DDP group were equivalent.The incidence rate of toxic effect was significantly higher in the HD-DDP group than in the LD-DDP group,but the rate of serious toxic effect in the two groups was similar.