Objective To explore the correlation between anemia and the pathogenesis and prognosis of patients with lung cancer. Methods From January 2013 to December 2014, 257 patients with primary lung cancer who were firstly treated at the First Affiliated Hospital of Anhui Medical University were retrospectively analyzed. The clinical data of the patients were collected and the patients were divided into anemia group and control group. The relationship of gender, age, and pathogenesis with anemia was analyzed by x 2 test. Survival analysis was evaluated by Kaplan-Meier and Log-rank test. Results The TNM stage, lymph nodes and remote metastasis , and ECOG score between the two groups were statistically different (x 2 values were 7.94, 4.97, 4.69, 9.02, all P< 0.05). The survival of the two groups showed statistical differences (x2=7.02, P=0.008). Conclusion Anemia might be correlated with the stage, lymph nodes and remote metastasis, ECOG score and prognosis of patients with lung cancer.

Acquired resistance of EGFR-TKIs has become the major limitation of the efficacy of targeted therapy for lung cancer. Lung cancer has been treated by traditional Chinese medicine (TCM) combined with EGFR-TKIs, which originated from clinic. In recent years, reversing research has been conducted based on clinic application to discuss TCM intervening, improving and reversing EGFR-TKIs acquired resistance becoming a novel target for research. This article reviewed mechanism and effects of TCM herbs and compounds’ with the efficacy of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis strengthening the body resistance, and invigorating the circulation of blood, and proposed that the whole regulation and targeted therapy of TCM may carry out synergistic effect and become innovation treatment model for lung cancer.

Intermedin can promote tumor angiogenesis through a variety of signaling pathways. Hypoxia of tumor cells can induce an increased expression of intermedin. Recently, there have been a surge of researches on the relation between intermedin and tumor initiation, progression and metastasis. Intermedin may be a new target for tumor therapy.

Incisional hernia is open a major postoperative complication that abdominal surgery remains. The incision type, suture technique, and the choice of primary suture materials are the main factors affecting wound healing. Prophylactic subfascial non-absorbable mesh can be used in high-risk patients to prevent in-cisional hernia.

Endothelin-1 (ET-1) was characterized as a powerful vasoconstrictor and mitogen for smooth muscle. ET-1 binds to two types of receptors: ET_ A-R and ET_ B-R. Pulmonary arterial hypertension (PH) is a severe condition characterized by a progressive increase in pulmonary vascular resistance. The Endothelial dysfunction plays an important role in the development of pulmonary arterial hypertension. PH can be treated by antagonism of ET-1.

Clonal hematopoiesis is a special mode of hematopoiesis in which hematopoietic stem cells with specific genetic and molecular biological characteristics differentiate into mature blood cells. It is the basis of a variety of hematological diseases. In depth study of its etiology, mechanism and characteristics are conducive to our understanding of the value of clonal hematopoiesis in different populations or diseases. This article reviews the latest progress in clonal hematopoiesis and its related clonal diseases.

Pulmonary function test is an indispensable auxiliary test for the measurement of children′s respiratory function.As one of the most important parameters in lung function test, peak expiratory flow has important guidance in respiratory diseases, neuromuscular diseases, surgery and so on.However, in addition to respiratory diseases, up to now, physicians have insufficient understanding of the application of peak expiratory flow in other diseases.Therefore, the application of peak expiratory flow in various clinical diseases was summarized, aiming at improving clinicians′ understanding of peak expiratory flow.

Objective: Angiotensin II (Ang II) contributes to modulating blood pressure by stimulation of Ang II AT1 receptors. We devised a rat transient middle cerebral artery occlusion (MCAO) model to assess whether oxidative damage is decreased after pretreatment with Angiotensin II AT1 receptor blocker (ARB). Methods: After 2 weeks pretreatment with ARB 0.5 and 1 mg/kg, the male Wister rats were subjected to 2 h middle cerebral artery occlusion (MCAO). At 24 h, the lumen diameter of middle cerebral artery, the plasma level of 8-hydroxy-2′-deoxyguanosine (8-OHdG), and HIF-1α levels were recorded and compared. Results: After pretreatment with ARB 0.5 and 1 mg/kg, blood pressure did not significantly change compared with that of controls. In the group of candesartan at 1 mg/(kg· day), the lumen diameter was significantly increased compared to that in control group [(86.0±5.0) μm vs. (69.0± 2.1) μm; P < 0.01, n = 6 - 8]. The plasma 8-OHdG levels of ARB pretreatment groups were decreased. In immunohistochemical findings, 8-OHdG- and HIF-1α-containing cells in ARB pretreatment groups were decreased. Conclusion: Brain ischemia and oxidative damage can be reversed by AT1 receptor blockade in normotensive rats after transient cerebral artery occlusion.

Objective: Angiotensin II (Ang-II) increases NADPH oxidase activity and stimulates the production of reactive oxygen species (ROS) including superoxide anion through Ang II AT1-receptor (AT1-R) activation. ROS is involved in various pathological processes in brain ischemia. We investigated whether the AT1-R blocker (ARB) candesartan can protect normotensive rats against brain ischemia. Methods: After 2-week pretreatment with candesartan, rats were subjected to 2 hours middle cerebral artery occlusion-reperfusion (MCAO-R) and 24 hours later, the infarct volume, iNOS, and eNOS mRNA in the internal carotid artery was recorded and compared. Results: Candesartan pretreatment reduced cerebral ischemia and oxidative brain damage after MCAO-R in normotensive rats, resulting in a decreased cortical infarct volume [0.5 mg/kg candesartan, (46.8±13.2) mm3; 1.0 mg/kg candesartan, (19.3±15.3) mm3 vs. control, (111.7±14.3) mm3; P<0.05, P<0.01, respectively]. Candesartan pretreatment increased the eNOS mRNA level in the internal carotid artery. Conclusion: In normotensive rats exposed to MCAO-R, candesartan protectes against brain ischemia. This effect may represent a significant therapeutic advantage and may induce end-organ protection even at normal blood pressure.

Objective To explor the safty and the effect of controlled intravenous analgesia with remifentanil on hyoxemia in obese patients with painless gastroscopy.Methods One hundred patients undergoing painless gastroscopy were randomly and equally allocated into 2 groups(50 each).In group R,anesthesia was induced with TCI(target-controlled infusion) of remifentanil,and the target plasma concentration (Cp) of propofol was set at 2ng/ml.In group N,the same volume of saline was continues infusion.MAP,RR and HR were monitored and recorded before the examination(T0),the time point of examination start(T1),gastroscopy go through glottis(T2),at the end of the operation (T3) and 5 min after examination (T4).The effect of sedation was evaluated by Ramsay.Except that,gastroscopy time,the satisfaction of patient,anesthetist and endoscopist were recored.In addition,apnea,bradycardia,hypoxemia,myoclonus,body movement,hypotension and postoperative complications were also recorded.Results Compared with group N,in group R,HR,MAP and rate of body movement were significantly decreased (P ＜ 0.05).Except that,the satisfaction of patient and endoscopist were increased (P ＜ 0.05).Conclusion TCI of remifentanil can provide satisfaction sedation for obese patients with painless gastroscopy with few adverse effects.