The ghrelin is an endogenous ligand of the growth hormone (GH) secretagogue receptor,which can regulate the secretion of GH,stimulate the appetite,adjust the energy metabolism,and improve the cardiovascular function.Children with congenital heart disease (CHD) usually suffered from malnutrition and growth retardation,which were connected with insufficiency of energy intake,poor absorption,and increase of nutritional requirement,anatomy and the changes of hemodynamics.Many infants with CHD gradually present ventricular dysfunction and growth restriction in their early childhood,which consequently lead to severe complications.Ghrelin is valuable in the early detection of potential CHD,plays an important role in improving the state of malnutrition and protecting the cardiac function,and provides an important reference to explore the new drug therapy for CHD.This review summarized the effects and significances of ghrelin on growth and cardiac function in infants with CHD.

Objective] To study the transmission of the Ishinpo versions ,understand the prevailing version of Ishinpo. [Method] With the research methods of the Chinese traditional history and philology,collect and sort historical cited references of the Ishinpo, by paying attention to three main emendation in the transmission history of Ishinpo. [Result] Ishinpo of Nakarai is the golden version for document research. The prevailing Ansei Ishinpo version of contemporary China is based on Nakarai version,which consists of twenty seven scrolls of Hei era and three scrolls of Edo Era. Ishinpo Versions have been divided into Emperor Nakarai versions,Uji versions and Family tradition versions. There are big differences in utilization and completeness of the three version system. The Emperor Nakarai versions are relatively good, of which the Nakarai version preserves best. The Uji versions are widespread, of which the RenHe Temple version is better preserved but lacuna. There are lots of lacunas in the family tradition versions, owing to circulateed copies. [Conclusion] In the three main emendation, of Ishinpo, mostly, the Nakarai version is the source edition, the Uji version is primary edition, and the family tradition version is the secondary edition. The paper, which is useful in the transmission of the Ishinpo and thus historical process of medical exchange between China and Japan, has established the system of Ishinpo versions, defined the golden version and the prevailing version.

Objective To analyze the literature of two core periodicals ,Military Medicine of the USA and Journal of the Royal Army Medical Corps of the UK,in order to highlight some important authors ,research institutes and some hot spots in the field of military medicine .Methods Citespace and Excel were used to analyze the data of authors institutes , keywords and citation frequency of the collected records .Results and Conclusion The core authors and critical research institutes are mainly from the USA and UK .America is absolutely taking the leading position in research on military medicine that focuses on injury risk factors , trauma and care , mental health , veteran affairs , military epidemiology and prevention .The results are of referential value for researchers and research administrators to find out about the main core authors ,research institutes and hot spots in military medicine .

Objective To study the ultrasonographic changes and blood flow characteristic ofthromboangiitis obliterans (TAO) by two-dimensional ultrasound and color Doppler imaging MethodForty-seven vessels of 40 patients with clinically suspected TAO vascular detected with two-dimensionalultrasound and color Doppler,and comparison with CT imagmg.Results Color Doppler imaging couldvisualize the arterial wall and blood flow echo filling case,and the spectrum showed the hemodynamicchanges.Conclusions Color Doppler is the first choice for the secondary check to the noninvasivethromboangiitis obliterans,close to the result by an angiography that is usually regarded as a sensitive,accurate and convenient diagnostic method.

Objective To observe the effects of ganglioside and piracetam in improving the neurological function in patients with hypertensive cerebral hemorrhage.Methods Ninety-six patients with hypertensive cerebral hemorrhage Were randomly divided into 2 groups,ganglioside group(48 patients)and piracetam group(48 patients).Ganglioside group used the amount 40mg ganglioside mixed with sodium chloride injection(100ml,concentration 0.9%),and the piracetam group uesd piracetam(20g)mixed with the same injection.Both the patients of the 2 groups were given intravenous drip once a day,then after continuous 3 weeks,the general information and the improvement of nerve were observed.Results The effective rate and excellent rate of ganglioside group were remarkably higher than piracetam group,there was significant difference between the two groups(P＜0.05).Conclusion Ganglioside was better than pimcetam in improving clinical symptoms and the neurological deficit of the patients with hypertensive cerebral hemorrhage.

Objective The purposes of the present study are to investigate the effects and mechanisms of Bu Shen Ning Xin Yi Jing Pill on premature ovarian failure (POF) through a clinical study. Methods Sixty women with POF were administered and randomized into the treatment group and the control group. Every group had thirty cases. Patients in the treatment and control groups were requested to have the Bu Shen Ning Xin Yi Jing Pill and the Liu Wei Di Huang Pill, respectively. Six-month duration was considered as a therapeutic course. The serum levels of follicle stimulating hormone (FSH) and estradiol (E2) were determined by the chemistry luminescence method. Differences between the treatment and control groups were investigated.Results Improved menstruation were revealed in both groups and the treatment group showed significant improvement than the control group (P<0.01). In the treatment group, serum FSH levels sharply dropped after treatment, while the serum E2 levels significantly elevated compared with those of prior-treatment (P<0.01) . The total effective rate in the treatment group was 70% (21 cases), whereas 40% in the control group (12 cases). The difference had statistical significance (P<0.01) .Conclusion The BuShen NingXin YiJing Pill is effective in the treatment of premature ovarian failure via significant improvements in the clinical symptoms and balance of the endocrine hormones.

Objective To determine whether pancreatic ductal preservation(pancreatic ductal injection of sparing TIUW solution at the time of pancreas procurement)can improve islet yield and function after cold preservation of pancreas.Methods Pancreases were classified into five groups:fresh pancreases(group1 ,n= 10);preserved for 6 hr in TIUW solution without and with pancreatic ductal preservation by TIUW solution(group2, n=10 and group3, n = 10);preserved for 24 hr in TIUW solution without and with pancreatic ductal preservation by TIUW solution(group4 ,n= 10 and group5,n= 10).Dithizon(DTZ)staining was used to identify islet morphous and yield, trypan blue uptake(TBU)was used to assess the nonviability of islets, the insulin secretory response to glucose was used to evaluate islet function in vitro, islet transplantation was used to determine islet function in vivo.Results Islet yields per pancreas after purification in group 1 to 5 were 590± 127, 272 ± 50,454 ± 65, 253± 56, 447 ± 66(islet equivalent ± SD), respectively.Percentage of nonviable islets in grouplto5were(5.7±4.2)%,(18.3±6.5)%,(11.7±4.2)%,(26.3±5.6)%,(15.0±5.3)%.Stimulation index in group 1 to 5 were 7.32±2.32, 4.81±1.17, 7.56±2.44, 2.88±1.00, 5.71±1.90.Cure rates in group 1 to 5 were 100%, 0%, 100%, 0%, 70%.In this study, the differences were significant between control groups and experimental groups(P＜0.05, group 2 vs.group3 and group4 vs.group5).Conclusion The pancreatic ductal preservation can improve islet yield and function.

Four methods for evaluating the academic impact of scholars were described according to their literature information, including subjective evaluation method, bibliometric method, social network analysis and comprehen-sive evaluation method .Their development trend was studied by analyzing their characteristics and applications .

Autophagy is a powerful process for removing such proteins and for maintaining homeostasis.However,autophagy dysfunction has also been implicated in the pathogenesis of vari-ous neurodegenerative diseases,including Parkinson 's disease (PD).Recent studies have shown that TFEB could regulate au-tophagy and lysosome function through regulating the expressionof the relatedgenes.Thus,TFEB plays a key role in the occur-rence of Parkinson's disease.Therefore,this article will make a review of the regulatory mechanism of TFEB and its role in Par-kinson's disease.

This paper reports a child with acute schistosomiasis,the routine X-ray of chest indicates the case is a typical pulmonary schistosomiasis.