1.Experimental Study on Effects of Hypoglycemic and Antiobesity of L-Arabinose in New Zealand Rabbit
Wei HAN ; Hanzhou WU ; Caixia YANG
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(03):-
Objective To research the function of hypoglycemic and antiobesity of L-Arabinose in New Zealand rabbit. Methods Thirty-two New Zealand white rabbits were randomly divided into 4 groups, 8 rabbits in each group. The control group was fed with high fat and high sucrose diet only. L-Arabinose group was fed with high fat and high sucrose diet along with L-Arabinose, the dosage were 0.308 5, 0.617, 0.925 5 g/kg respectively. After fed for two months, all groups were given L-Arabinose, and blood glucose was detected after orally given sucrose 0, 0.5, 2 h. After intervention of L-Arabinose for one month, the data of weight, food intake, stool quantity and the fat index were observed. Results L-Arabinose decreased significantly sucrose absorption, lower the fasting glucose level and the data of area-under-curve (AUC) significantly. Conclusion L-Arabinose proved to be highly effective in preventing the rise of circulating glucose and fat.
2.Analysis of the Utilization of Antidepressant Drugs in 11 Hospitals from Zhejiang Province during 2013-2017
China Pharmacy 2019;30(5):704-707
OBJECTIVE: To investigate the application of antidepressants in Zhejiang province and to provide reference for rational drug use in clinic. METHODS: WHO-recommended defined daily dose (DDD) method was used to statistically analyze consumption sum, main types, defined daily dose system (DDDs), daily drug cost (DDC) and ranking ratio (B/A value, i.e. consumption sum rank/DDDs rank, B/A<1 means the price of drugs was higher, whereas the price of drugs was lower) of antidepressant drugs in 11 hospitals from Zhejiang province during 2013-2017. RESULTS: The consumption sum of antidepressants was increased year by year in 11 hospitals from Zhejiang during 2013-2017, and increased from 3 235 200 yuan in 2013 to 4 569 100 yuan in 2017; the proportion of consumption sum of antidepressants in total consumption sum of all drugs kept stable, ranging from 0.47% to 0.50%. The top 5 drugs by consumption sum were fluoxetine, duloxetine, olanzapine and venlafaxine; consumption sum of escitalopram accounted for a larger increase (proportion ration increased from 8th place in 2013 to first place in 2017). Within 5 years, DDDs of fluoxetine, paroxetine and sertraline took up the first 3 place; DDC of olanzapine, quetiapine and duloxetine took up the first 3 place; the drugs with B/A value<1 included duloxetine, olanzapine, venlafaxine and quetiapine, etc; the drugs with B/A value>1 were paroxetine and sertraline. CONCLUSIONS: The use of antidepressant drugs in 11 hospitals from Zhejiang province is rational in structure; selective 5-hydroxytryptamine (5-HT) reuptake inhibitors (SSRI), selective 5-HT and noradrenaline reuptake inhibitor (SNRI) take up the predominant place. New antidepressant drug escitalopram shows a good clinical prospect.