Introduction: Rhabdomyosarcoma (RMS) is the major soft tissue sarcoma in childhood, correlated with high morbidity and mortality. We defined clinico-epidemiological profiles and prognoses on pediatric RMS patients in Indonesia. Methods: This study was conducted retrospectively by examining all medical records of pediatric RMS patients in Dr. Sardjito Hospital, Yogyakarta, Indonesia, for 5 years from 2011 until 2016. Results: There were 21 RMS patients in this study. The median age of our subjects was 6 years and predominantly under 10 years old (71.4%). There was a greater tendency for the disease in males, with a male to female ratio of 2 : 1. The head and neck region was the primary tumor site (52.4%). The most common histological subtype of tumor was embryonal RMS (85.7%). The most common measured diameter for tumor size was ≤ 5 cm (42.9%). Almost half of the patients received combination therapy, including surgery and chemotherapy (47,6%). Overall survival rate was 71.7%. Conclusion: We concluded that the epidemiological profile and prognostic factors of childhood RMS patients in our center are similar to the world reference data and were clinically associated with the mortality rate of our RMS patients, but the findings were not considered statistically significant.

Introduction: Wilms tumor is the major kidney neoplasm in childhood. Approach to therapy gives a 90% 2-year survival rate. However, the mortality rate in developing countries is relatively still high. Research about the clinicopathological profile of Wilms tumor in Indonesia is very limited. This study aimed to investigate the Wilms tumor patients in an Indonesian setting. Methods: This research was a descriptive observational study using a cross-sectional design. Clinical and pathological data were collected from patients’ medical records in Dr. Sardjito General Hospital, from 2011 to 2016. Results: Twenty-five patients were recruited with 52% female subjects. The mean age at the first diagnosis was 38 months. All patients had unilateral tumors. The tumor size was mostly (67%) equal or more than 10 cm. The most frequent symptom was abdominal mass. Ninety-two percent of patients have favorable histology. Most cases (68%) had triphasic morphology. The most common metastasis site of tumor was the liver, followed by the lung, skeletal bone, and spleen. Eighty-four percent of patients received chemotherapy, 80% received surgery, and 28% received radiotherapy. The gender distribution and the most common metastasis site in this study were different compared to previous studies. Conclusion: The clinicopathological profile of Wilms tumor in Yogyakarta, Indonesia, generally matches with other studies from other countries, except the gender distribution and the most common metastasis site. Further prospective studies regarding the prognosis of the patients are urgently needed.