Objective　To investigate the effect of positive pressure ventilation on radiosensitivity of the patients suffering from primary lung cancer. Methods　Thirty cases of lung cancer were randomly divided into two groups: ① combining therapy group: patients treated with posi tive pressure ventilation using BiPAP respirator and radiotherapy;② simple radi otherapy group. The changes of PaO2, SaO2, blood white cells and the cellula r immunological function were observed before and after treatment. Resul ts　Nasal or naso-facial positive pressure ventilation with BiPAP respi rator increased PaO2 significantly with the maximum of 7.5 kPa, SaO2 was ma inteined at above 95%. No significant change for the cellular immunological func tion was found in the combining therapy group （P>0.05）and only one patient with leukopenia（6.7%）. But in the radiotherapy group, the lymphocyte transfor mation efficiency and the ratio of CD4/CD8 were obviously decreased（P<0 .01), and leukopenia was found in 5 cases（33.3%）. Conclusion　 Nasal or naso-facial positive pressure ventilation with BiPAP respirator could improve the effect of radiotherapy for lung cancers. It could also increase PaO 2 significantly and has protective rote to the marrow and cellular immunologic al function of the patients.

in the period from Lanuary, 1983 to June, 1990, a total of 980 cases of cor pulmonale were hospitaluzed in this institute. Among the 980, 154 cases were complicated with multiple organ failure (MOF), and 114 cases out of the 154 died with a mortality rate of 74%. Besides the heart and the lungs, the organs involved were the brain, the liver, the gastrointestinal tract, the kidneys and the blood system. It was found that MOF more often occurred in elderly persons. The older the patient is, the more the organs will be involved and the higher the mortality rate will be. Infection especially that of gram negative bacilli was the main factor to induce MOF. The combined administration of penicillin and the antibiotics of cephalosporin group was quite helpful to control the infections, which is the key step in the management of such cases, when the antibiotics of aminoglycoside group were used, special attention must be paid to the prevention of their toxic effects on the kidneys High-frequency jet ventilation is not suitable to treat cor pulmonale complicated with MOF.

The cellular proliferative activity (CPA) of the surgical specimens of 35 patients with lung cancer,10 patients with benign lesions of the lungs,and 10 normal subjects was studied with flow cytometry.It was found that CPA was significantly higher in lung cancer than in benign pulmonary lesion and it was significantly higher in benign pulmonary lesion than in the normal lungs.The finding suggests that CPA is useful in the screening of lung cancer patients.

BACKGROUND: Limited published research has examined the relationships of negative life events and coping styles with sleep quality in Chinese junior high school students. We aimed to investigate the prevalence of poor sleep quality and to clarify the role of coping styles between negative life events and sleep quality. METHODS: A cross-sectional study of 3081 students was conducted in Ganzhou City, Jiangxi Province, Southeastern China. Adolescent Self-Rating Life Events Checklist, Simplified Coping Style Questionnaire, and Pittsburg Sleep Quality Index were applied to assess negative life events, coping styles, and sleep quality, respectively. Descriptive analyses, independent-samples t tests, one-way analyses of variance, Pearson correlation analyses, and structural equation modeling (SEM) were applied to analyze the data. RESULTS: The prevalence of poor sleep quality was 26.7%. Negative life events (B = 0.038, P < 0.001) and negative coping style (B = 0.049, P < 0.001) demonstrated a positive association with poor sleep quality, while positive coping style indicated a negative association with poor sleep quality (B = -0.029, P < 0.001). Interactions of negative life events and coping styles with sleep quality were not found (all P > 0.05). The association between negative life events and sleep quality was mediated by negative coping styles. CONCLUSIONS Our results indicated that poor sleep quality was common in these Chinese adolescents. Negative life events and negative coping style were associated with an increased prevalence of poor sleep quality, while the positive coping style was related to a decreased prevalence of poor sleep quality. A negative coping style mediated the association between negative life events and sleep quality.
Adaptation, Psychological ; Adolescent ; Child ; China ; Cross-Sectional Studies ; Humans ; Life Change Events ; Psychology, Adolescent ; Psychology, Child ; Sleep