OBJECTIVE:To prepare a compound gel composed of chlorphenamine(CH) and ephedrine hydrochloride(EP) METHODS:The gel was prepared by taking carbomer 940 as emulgator,trolamine as pH adjuster and propylene glycol as preservative The contents of CH and EP in gel were determined with the first order derivative spectroanalysis and dual-wave_length spectrophotometry RESULTS:The prepared gel exhibited fine consistency and moderate viscosity The content of CH was 101 0% with an average recovery of 100 4%,RSD 0 99% and the content of EP was 100 4% with an average recovery of 101 3%,RSD 1 7% CONCLUSION:This preparation is stable and non-irritative It is a newly developed preparation for tre_ating allergic rhinitis