Objective: To observe the curative and side effects on malignant pleural effusion treated with Ya Dan Zhi's grease (YDZ) and DDP by injecting chest. Methods:Patients were divided into 3 groups randomly: treatment group (24 patients of MPE, injected to chest with DDP60mg and YDZ80mL once every week)、YDZ group (25 patients)、DDP group (23 patients), observing the effects、strength improvement and the side effects.Results: The toltal effective rates in the treatment group was 88.33% and YDZ group 56%、DDP group 56.52% respectively ( P