Objective To investigate the relationship between uric acid levels and lipid metabolism in Uyghur and Han people who underwent physical examination.Methods From February 2012 to February 2013,8 197 blood samples were collected for the tests of serum uric acid and some other relevant lipid metabolism indicators in the First Affiliated Hospital of Xinjiang Medical Uni-versity.Results The uric acid level of Han was higher than that of Uyghur people(P <0.05),the levels of uric acid has gradually increased with the growing age both in the Uygur and Han people.The uric acid and high-density lipoprotein and apolipoprotein-A showed negative correlation between Uyghur and Han(P <0.05),however,the uric acid and other factors showed positive correla-tion(P <0.05).Conclusion There is ethnic differences in the level of uric acid and the prevalence of hyperuricemia in people who underwent physical examination of Urumqi,there are correlations between uric acid levels and the lipid metabolism.