2.Clinical Experience of Right Heart Bypass Using Heparin-coated Tube and Roller Pump System.
Hajime OHZEKI ; Satosi NAKAZAWA ; Akira SAITO ; Hisanaga MORO ; Hirofumi OKAZAKI ; Junichi HAYASHI ; Haruo MIYAMURA ; Shoji EGUCHI
Japanese Journal of Cardiovascular Surgery 1992;21(5):510-514
A 47 year-old man with frequent attacks of ventricular tachycardia (VT) due to arrhythmogenic right ventricular dysplasia (ARVD) developed severe right heart failure following cryoablation of the multiple VT focuses. Inotropic support and intraaortic balloon pumping failed to maintain the systemic circulation, so that we performed the right heart bypass (RHB) using a heparin-coated tube and roller pump. With the use of RHB, systemic circulation improved. We attempted to wean the patient off after 14 days RHB support. However this was unsuccessful because of poor RV function, and RHB was recommenced. The patient finally died of multiple organ failure on the 21st postoperative day, but the major organ function was well maintained for at least two weeks. The heparin-coated tube and roller pump system is easy to handle, and is suitable as a short term lifesaving adjunct for severe right ventricular failure.
3.Circulatory Support for the Operation of the Descending Thoracic Aorta with a Heparin-coated Tube and a Roller Pump.
Akira SAITO ; Shoji EGUCHI ; Jun-ichi HAYASHI ; Kazuo YAMAMOTO ; Hisanaga MORO ; Hajime OHZEKI
Japanese Journal of Cardiovascular Surgery 1992;21(5):515-518
We applied a new circulatory support system to three patients with descending aortic operation between 1989 and 1990. The new system consisted of a polyvinylchloride tube coated with hydrophilic heparinized polymer and a roller pump. Low doses of heparin (0.5mg/kg) were administered in two patients and none in one patient before aortic bypass. The aortic crossclamping time ranged between 52 and 64 minutes. In two patients, whose inflow cannulae were 18Fr. or 20Fr., successful bypass flow exceeded 2l/min and optimal distal aortic pressure were maintained during aortic cross-clamping. The postoperative courses of these patients were uneventful, free from thromboembolic episodes and subsequently discharged from hospital. Furthermore, postoperative careful examination revealed no thrombus formation occurred in the three devices. In conclusion, our new simple, antithrombogenic circulatory system is extremely useful for descending aortic operations.
4.Intra-coronary Shunt for Coronary Artery Revascularization in the Beating Heart.
Masakazu Sogawa ; Akira Saito ; Osamu Namura ; Hajime Ohzeki ; Hisanaga Moro ; Jun-ichi Hayashi
Japanese Journal of Cardiovascular Surgery 1998;27(4):222-226
A minimally invasive approach to coronary artery revascularization without cardiopulmonary bypass has been performed recently and its feasibility and effectiveness have been proved. However, occlusion of the coronary artery during anastomosis in the beating heart is liable to cause myocardial ischemia or infarction. To prevent these and to perform minimally invasive coronary artery bypass on the beating heart safely, intra-coronary shunt was developed and applied in animal experiments. Materials and methods: The left internal mammary artery was harvested endoscopically and anastomosed to the left anterior descending coronary artery in the beating heart without cardiopulmonary bypass in seven pigs. Three of them utilized intracoronary shunt tubes (group S) and the other did not (group C). Results: Use of an intracoronary shunt tube facilitated non-blood exposure of the coronary artery during anastomosis. In group C, three pigs out of four had ventricular fibrillation during occlusion for the anastomosis. In group S the anastomosis was accomplished without change of ECG except one case and without any elevation of CPK-MB and Troponin T during and after the anastomosis. Conclusion: These results showed that an intra-coronary shunt can prevent myocardial ischemia and may be very useful especially to those who do not develop collateral branches from other coronary arteries.
5.An Experimental Evaluation for Blood Compatibility of Mock Cardiopulmonary Bypass Systems.
Hisanaga MORO ; Hajime OHZEKI ; Mitsuo UENO ; Osamu NAMURA ; Satoshi NAKAZAWA ; Shoichi TSUCHIDA ; Junichi HAYASHI ; Haruo MIYAMURA ; Shoji EGUCHI
Japanese Journal of Cardiovascular Surgery 1992;21(5):447-451
To estimate the blood compatibility during extracorporeal circulation, we designed mock circulation system consisted of a membrane oxygenator and vinyl circuit with roller pump. Primed with 200ml Ringer's acetate and 200ml of fresh whole human blood, mock circulation was worked at flow rate 0.5l/min for 6hr. Heparin was not primed, oxygenator did not fill any gases and circulation was keeping at 37°C. The thrombin-antthrombin complex and fibrinopeptide-A showed progressive increase and fibrinogen correspondingly decrease. Nevertheless, the plasmin α2 plasmin inhibitor complex and D-dimer showed minimal changes within normal range in spite of increasing fibrinopeptide B β 15-42. We can not find any signs of secondary fibrinolytic activity. On the other hand, the platelet was persistently activated as shown statistically significant increase in β-thrombogloblin and platelet factor IV. Significant elevations of complement 3a and 4a were seen with increase of complement 5a and activated oxygen productivity by neutrophilic leucocytes. In conclusion, moderate and limited blood alterations occurred in mock cardiopulmonary bypass circuit.