Objective To investigate the impact of initial dialysis dose on residual renal function of peritoneal dialysis patients. Methods Clinical data of 178 consecutive patients on initial peritoneal dialysis received follow-up for 3 months in our department were analyzed retrospectively. According to urinary volume after peritoneal dialysis, patients were divided into three groups: lower urine group (LU, n=97), decreased urine group (DU, n=19), and normal urine group (NU, n=62). Their dialysate volume, dialysate glucose content, uhrafiltration, weekly renal urea clearance normalized to total body water (Kt/V), body weight, edema degree and daily urinary volume were recorded and association among these parameters were examined. Results There were no significant differences in age, gender, serum albumin and total Kt/V among three groups. One month after dialysis, body weight and edema degree in DU group were significantly higher than those in LU and NU groups (all P<0.05); the dialysate volume, dialysate glucose content, ultrafiltration and renal Kt/V in DU group were significantly higher than those in LU group (all P<0.05), but were not significantly different from NU group. Three months after dialysis, in DU group, dialysate volume, ultrafiltration and urinary volume decreased significantly (P<0.05) as compared with LU and NU groups, but body weight and edema degree were still higher, and Kt/V decreased significantly as well. Conclusions The residual renal function (urinary volume and Kt/V value) of initial patients will be deteriorated by over ultrafihration in early stage of peritoneal dialysis. Excess uhrafiltration should be avoided for the initial peritoneal dialysis patients.

Objective To explore the application value of ultra -high frequency ultrasound in detection of femoral artery stenosis in rabbits.Methods Twenty-four healthy male New Zealand white rabbits (body weight 2.5 -3.0 kg) were randomly divided into three groups , 8 rabbits in each group.Preparation of femoral atherosclerosis model : the rabbits were fed with high fat diet for 4 weeks, 8 weeks and 12 weeks after femoral artery balloon injury , respectively.The changes of cholesterol level were observed .We used ultra-high frequency ultrasonic probe to observe the femoral artery , to assess the diameter stenosis rate and peak systolic velocity (SPV) at the symptomatic side, and the histological areal stenosis was evaluated.Results 1.The blood cholesterol levels were increased after fed high cholesterol diet , with a significant difference among the groups (P <0.001); 2.There was a stenosis to a different degree in the modeling artery after fed high cholesterol diet for 4 wks, 8 wks, and 12 wks, and the stenosis degree was increased gradually .At 12 w, the degree of stenosis was higher than that at 4 w and 8 w, respectively, showing statistical significance ( P <0.001).At the symptomatic side, the peak systolic flow velocity was increased , and it was higher at 12 w than that at 4w and 8 w, respectively.3.With the extension of time, the arterial stenosis rate was increased along with the time course (P <0.05). Conclusions 1.High fat diet combined with balloon injury can cause varying degrees of rabbit femoral artery stenosis ; 2. Ultrahigh frequency ultrasound can clearly show different degrees of rabbit femoral artery stenosis , and can be used for detecting the lesions in animal models of peripheral vascular diseases .

Objective To grasp the current situation and trend of health personnel development in public TCM hospitals through the analysis of health personnel statistics data of public TCM hospitals in China; To provide decision-making references for management departments. Methods Data were from the National Health and Family Planning Commission Statistical Information Center. This article analyzed staff number, the average speed of development, the average annual growth rate, health staff age, academic qualifications and job titles and other indicators of TCM public hospitals during 2010-2015. Results From 2010 to 2015, there was an annual increasing tendency of the number of TCM health personnel, and the average annual growth rate was 5.9％, but the growth of the percentage of the TCM health personnel to the total health personnel was only 0.3％. In 2015, the proportion of TCM health personnel was less than 50％; the doctor-to-nurse ratio was 1:1.18; the educational level of postgraduate and undergraduate were 14.0％ and 48.0％ respectively, less than the average level of national hospitals. Conclusion From 2010 to 2015, there is an increasing tendency of the TCM health personnel of public TCM hospitals, but the proportion of TCM health personnel is low. The doctor-to-nurse ratio is reasonable gradually, but there is still a gap compared with the average level of the national hospitals. The average age of technical health personnel tends to be younger. The proportion of high educational level health personnel is increasing, but the proportion of senior technical position is reduced. The management departments should take appropriate measures to promote the rational allocation of human resources and development of TCM hospitals.

To further uncover the scientific significance and molecular mechanism of the Chinese herbs with pungent hot or warm natures, endogenous and exogenous expression systems were established by isolation of dorsal root ganglion (DRG) neurons and transfection of HEK293 cells with TRPV1 channel gene separately. On this basis, the regulation action of capsaicin, one main ingredient from chili pepper, on TRPV1 channel was further explored by using confocal microscope. Besides, the three-sites one-unit technique and method were constructed based on the brown adipose tissue (BAT), anal and tail skin temperatures. Then the effect of capsaicin on mouse energy metabolism was evaluated. Both endogenous and exogenous TRPV1 channel could be activated and this action could be specifically blocked by the TRPV1 channel inhibitor capsazepine. Simultaneously, the mice's core body temperature and BAT temperature fall down and then go up, accompanied by the increase of temperature of the mice's tail skin. Promotion of the energy metabolism by activation of TRPV1 channel might be the common way for the pungent-hot (warm) herbs to demonstrate their natures.

Objective An 80 years old man,suffered from cardiopulmonary arrest during swimming.After successfully cardiopulmonary resuscitation,he was sent to a hospital.After examination and inspection,he was diagnosed as cardiopulmonary arrest,aspiration pneumonia,hyperlipidemia,high level of creatine kinase.We prescribed a statin for the hyperlipidemia,but the level of creatine kinase was higher and higher.Finally he was diagnosed as hypothyroidism and lung cancer.We considered that severe weakness may be the reason of cardiopulmonary arrest in swimming pool.

Objective To evaluate the clinical efficacy and adverse effects of brucea javanica oil emulsion combined with DP chemotherapy in treating advanced non-small-cell lung cancer.Methods Totally 48 patients with advanced non-small-cell lung cancer were divided into two groups randomly by mechanical sampling method.Twenty-four cases in treatment group were treated by brucea javanica oil emulsion combined with DP chemotherapy, while 24 cases in control group were treated by DP chemotherapy only.The clinical effects were evaluated after treatment of two cycles.Results The short-term effective rate was 54.2% (13/24) in treatment group and 45.8% (11/24) in control group, and there was no significant difference between two groups ( χ2 = 0.333, P = 0.564).The rate of increased and stable life quality was 87.5%(21/24) in treatment group and 58.3%(14/24) in control group,and there was significant difference between two groups (χ2 = 5.169,P = 0.023).The rate of increased and stable weight was 79.2% (19/24) in treatment group and 45.8%( 11/24) in control group, and there was significant difference between two groups (χ2 = 5.689,P = 0.017).The incidence of nausea or vomiting was 45.8% (11/24) in treatment group and 41.7%( 10/24 ) in control group, and there was no significant difference between two groups (χ2 = 0.085, P = 0.771 ).Compared with those in control group, patients in treatment group had less adverse effects in decreasing of peripheral blood leucocytes and showed better immune function.Conclusion Brucea javanica oil emulsion combined with DP chemotherapy in treating advanced non-small-cell lung cancer has good clinical effect, especially enhances the quality of life, improves immune function and decreases the adverse effects of chemotherapy.

To explore the development tendency and major influential factors of traditional Korean medicine (TKM) resource and service by statistics analysis. Data are mainly from the Yearbook of Traditional Korean Medicine (2009-2015). Ministry of Health and Welfare Statistical Yearbook 2016, and the Ministry of health and welfare practicing qualification management system. This article analyzed the related indicators, such as the average annual growth rates and the proportion in the national medical system. From 2006 to 2015, the average annual growth rate of the number of TKM hospital and TKM clinics were 7.0％ and 3.2％ separately; the average annual growth rate of TKM doctor and TKM pharmacists were 4.3％ and 10.0％ separately; the average annual growth rate of the number of beds in TKM institutions were 9.3％; and the average annual growth rate of the number of applications for outpatient and inpatient reimbursement for medical insurance of TKM institutions were 12.3％ and 20.5％ separately. From 2006 to 2015, the resources and services of TKM presented an increasing tendency, and the accessibility of TKM resource and service was enhanced. It is suggested that China should use reference from the aspects of strengthening policy, expanding the sources of capital investment, and expanding the coverage of medical insurance.

Objective To provide a reference for the selection of frailty assessment tools for stroke patients by conducting a literature review of existing frailty assessment tools for stroke patients.Methods Systematic searches were conducted in PubMed,Web of Science,EMbase,SinoMed,Wanfang,VIP,and China National Knowledge Infrastructure(CNKI)databases from their inception to May 2023.The literature that met the research purpose and question were screened,and the basic in-formation of each article,including the first author,publication year,country of publication,type of research design,name of the assessment tool,dimensions of scale,the number of items,and assess-ment time,was extracted.Results A total of 1,729 articles were retrieved in this study.After multi-ple screenings,22 articles(including 8 frailty assessment tools)were ultimately included.The analy-sis results showed that the evaluation indicators,evaluation time,and evaluation methods of the 8 frail-ty assessment tools were different and had their own advantages and disadvantages.Among them,the frailty index was the most commonly used frailty assessment tool for stroke patients.The selection of ef-fective frailty assessment tools for stroke patients is essential for strengthening prestroke risk stratifica-tion and improving poststroke outcomes.Conclusion There are significant differences among different frailty assessment tools,and existing assessment tools have limitations in measuring frailty in stroke pa-tients.Comprehensive assessments should be conducted in combination with clinicians'experience and judgment.New frailty assessment tools are needed in future research to better guide the rehabilitation treatment and management of stroke patients.

Objective To investigate the prevalence of sarcopenia in the elderly people in a community of Chenghua District of Chengdu city and analyze its relationship with geriatric frailty syn-drome.Methods A total of 586 elderly people in a community of Chenghua District of Chengdu city were selected as research objects for comprehensive geriatric assessment,including general data sur-vey,anthropometric measurements(height,weight,grip strength,pace and skeletal muscle),and frailty screening scale survey.Incidence conditions of sarcopenia and geriatric frailty syndrome were evaluated,and the relationship between sarcopenia and geriatric frailty syndrome was analyzed.Results Totally 83 cases were diagnosed as sarcopenia,and the prevalence of sarcopenia was 14.98％.There were no significant differences in gender,education level,smoking,alcohol con-sumption and basic diseases between the sarcopenia group and the normal group(P＞0.05).Com-pared with the normal group,the sarcopenia group had a significant lower ratio of patients aged 60 to 74 years old,a significant higher ratio of patients aged 75 to 84 years old and ≥85 years old,and a significant higher incidence of geriatric frailty syndrome(P＜0.05).Compared with the normal group,the sarcopenia group had significant lower grip strength,pace,skeletal muscle mass of the four limbs,and appendicular skeletal muscle index(ASMI)(P＜0.05).Multivariate analysis showed that age,body mass index(BMI)and geriatric frailty syndrome were influencing factors for sarcopenia(P＜0.05).Conclusion Prevalence of sarcopenia in the elderly people in a community of Chenghua District of Chengdu city is relatively high,and sarcopenia is closely correlated with the occurrence of geriatric frailty syndrome.

Objective To provide a reference for the selection of frailty assessment tools for stroke patients by conducting a literature review of existing frailty assessment tools for stroke patients.Methods Systematic searches were conducted in PubMed,Web of Science,EMbase,SinoMed,Wanfang,VIP,and China National Knowledge Infrastructure(CNKI)databases from their inception to May 2023.The literature that met the research purpose and question were screened,and the basic in-formation of each article,including the first author,publication year,country of publication,type of research design,name of the assessment tool,dimensions of scale,the number of items,and assess-ment time,was extracted.Results A total of 1,729 articles were retrieved in this study.After multi-ple screenings,22 articles(including 8 frailty assessment tools)were ultimately included.The analy-sis results showed that the evaluation indicators,evaluation time,and evaluation methods of the 8 frail-ty assessment tools were different and had their own advantages and disadvantages.Among them,the frailty index was the most commonly used frailty assessment tool for stroke patients.The selection of ef-fective frailty assessment tools for stroke patients is essential for strengthening prestroke risk stratifica-tion and improving poststroke outcomes.Conclusion There are significant differences among different frailty assessment tools,and existing assessment tools have limitations in measuring frailty in stroke pa-tients.Comprehensive assessments should be conducted in combination with clinicians'experience and judgment.New frailty assessment tools are needed in future research to better guide the rehabilitation treatment and management of stroke patients.