OBJECTIVE:To investigate the utilization and the economic value of the medicare drugs in our hospital. METHODS: The utilization of the medicare drugs in our hospital from 2001 to 2006 were analyzed statistically by sequencing drug consumption sum and DDDs. RESULTS: The consumption of medicare drugs represented 81.9% of the total drugs used in the clinic in our hospital. Both DDDs and consumption sum increased year on year. CONCLUSION: The utilization of medicare drugs was rational with good economic value, yet the application of new drugs was still on the high side in spite of their high prices.

Objective To detect the expression of STAT3 in breast cancer and adjacent paracancerous tissues ,then analyze the correlationship between its expression level and some other clinical features of breast cancer,and to evaluate its significance in prognosis of patients with breast cancer. Methods 130 breast cancer patients were enrolled in the Jiangmen Central Hospital ,and 61 cases of adjacent normal tissues. The expression of STAT3 was detected by IHC. We compared the expression of STAT3 between the two groups and analyzed the relationship between STAT3 and other clinical features. Results The expression of STAT3 in breast cancer group was much higher than the adjacent paracancerous tissues. STAT3 expression showed obvious correlationship with clinical stage ,tumor size ,lymph node metastasis ,the expression of ER and PR ,but no statistical correla-tion with age ,histological grade and Her-2 expression. Survival analysis showed that patients with high STAT3 expression level had a significantly poor prognosis. The Cox regression analysis showed that PR and STAT3 expres-sion were independent prognostic factors for patients with breast cancer. Conclusion These results may implicate that STAT3 will promote the development of breast cancer and higher expression of STAT3 indicates the poor survival rate.

Oxygen enrichment of room air is an effective way to resist hypoxia at high altitude, but it may introduce a potential fire hazard. In common, the burning rate of light and thin homogeneous solid in oxygen enriched atmosphere was used to assess the fire hazard. For the purpose of measuring the burning rate of light and thin homogeneous solid in oxygen enriched atmosphere, we used the methods of laser contact ignition and direct calculation of burning rate, and invented a device that includes mixing gas system, ignition equipment, system of measuring the burning rate and self-made specimen frame. By using the homemade device, we studied the burning rate of filter paper under low pressure and in oxygen-enriched atmosphere and in that of the oxygen concentration of reached stationary burning rate. The results showed that this device was simple, and could obtain the burning rate of light and thin homogeneous solid quantitatively.
Air Pressure ; Altitude ; Atmosphere Exposure Chambers ; Environment, Controlled ; Equipment Design ; Fires ; prevention & control ; Oxygen ; analysis

Objective To evaluate the efficacy of the sleeve type guide growth rod sliding automatically with the growth of piglet spine.Methods Fourteen 4-month-old piglets were randomly divided into growth rod group (n=8) and control group (n=6).Animals in growth rod group were implanted with the sleeve type guide growth rod system through the small incision of the tho racodorsal.Whereas ones in control group were just expose the bilateral lamina.On the day of surgery,6 and 12 weeks of postoperation,all piglets accepted the spinal X-ray examination.Measured the mean height of T8,T9 vertebral bodies,the average height of T7-8,T8-9,Tg-10 discs and the mean length of the rods through X-ray film.Spinal MRI was measured 3 months after the operation.The morphological changes of the plate were observed after HE staining.The morphological changes of the nucleus pulposus cells were observed and the thickness of the growth plate and the length of the growth bar were measured.Results Two piglets of growth rod group did not complete the experiment,1 piglet died of aspiration due to anesthesia resuscitation,and 1 piglet had infection after operation.The average height of T8,T9 vertebral bodies of the piglets in the growth rod group on the day after surgery and 3 months after operation was 18.26±3.26 mm and 27.15±4.18 mm,respectively,and the difference was statistically significant (F=16.868,P=0.002).Similarly,the mean height of T7-8,T8-9,Tg-10 discs of the piglets in growth rod group on the day after surgery and 3 months of postoperation was 1.79±0.24 mm and 2.14±0.23 mm,respectively,and the difference was statistically significant (F=6.455,P=0.029).The average height of T8,T9 vertebral bodies in the control group on the day after surgery and 3 months after operation was 17.86±3.50 mm and 28.63±4.45 mm,respectively,and the difference was statistically significant (F=21.654,P=0.001).Similarly,the mean height of T7-8,Ts-9,Tg-10 discs in control group at the day after surgery and 3 months of postoperation was 1.78±0.27 mm and 2.17±0.30 mm,respectively,the difference was statistically significant (F=5.928,P=0.035).There was no statistically significant difference in average height between T8 and T9 vertebral bodies in growth rod group and the control group at 3 months after operation (F=0.352,P=0.566).Similarly,There was no statistically significant difference in average height of T7-8、Ts-9、Tg-10 discs in growth rod group and the control group at 3 months after operation (F=0.053,P=0.823).The average sliding length of the growth rod in growth rod was 65.74 mm.Furthermore,growth plate chondrocytes and nucleus pulposus cells in EG and SG,all showed that the cells were arranged in order,the cell volume was large,the shape was round and the cytoplasm was rich.Simultaneously,there was no significant difference between the two groups in growth plate chondrocytes (P ＞ 0.05).Conclusion The sleeve type guiding growing rod can automatically slip to extend due to the driving force of young pig's spine growth,without obvious effects on the normal growth of piglet's spine.

OBJECTIVE：To know about the use of policy tools for trad itional Chinese medicine （TCM）inheritance and innovation policies in China ，and to provide reference for subsequent improvement of TCM inheritance and innovation policies. METHODS：The content analysis method was used to classify and code the policy texts related to TCM inheritance and innovation policies at the national level before Sept. 2020. Statistical analysis was carried out from the two dimensions of basic policy tools and the TCM inheritance and innovation system ，and related suggestions were put forward. RESULTS ：Nine related policy texts were collected ，which were published during 2007-2020. In terms of basic policy tool dimensions ，environmental policy tools were the most （46.47％），followed by supplying policy tools （41.36％）and demanding policy tools （12.17％）. The supply-based policy tools included scientific research and informatization support （25.67％），talent training （7.06％），infrastructure construction （5.6％），public health services （2.07％），and capital investment （used the least ，0.97％）. The demand-based policy tools included international exchanges and cooperation （5.11％），organization coordination （3.77％），industry shaping （1.82％），pilot/ demonstration projects （1.46％），the latter two contents were used less. Among the environmental policy tools ，laws and regulations were used the most （24.94％），followed by target planning （9.73％），intellectual property （6.57％），financial support （2.43％），policy publicity （1.95％），quality evaluation （0.61％），and medical insurance support （0.24％）. The dimensions of TCM inheritance and innovation system included scientific research and innovation （34.67％），management mechanism （19.59％）， Chinese medicine industry （18.37％），service system （18.00％）and team building （9.37％），among which team building was related less. CONCLUSIONS ：In order to better implement TCM inheritance and innovation policies in China ，it is recommended to optimize supply-based policy tools and highlight policy promotion functions ；increase demand-based policy tools to form an effective“pull force ”；adjust the structure of environmentalpolicy tools to improve the external environment for inheritance and innovation ；promote the full use of policy tools in the inheritance and innovation system to achieve planning goals.

Objective:To discuss the diagnostic value of miR-26a/b and relationship of this microRNA with clinicopathological features in patients with gastric cancer. Methods:The expression of serum miR-26a/b was detected in 121 patients with gastric cancer and 116 healthy controls using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). The relationship of miR-26a/b and clinicopathological parameters of patients were analyzed. The receiver operating curve (ROC) was constructed to in vestigate the value of miR-26a/b in the diagnosis of gastric cancer. Results:The relative expression levels of serum miR-26a and miR-26b in patients with gastric cancer were lower than those in the control group (1.60±1.02 vs. 5.35±0.44;1.44±0.71 vs. 5.35±0.71;P<0.05). The relative expression level of miR-26a/b correlated with TNM stage, and the relative expression level of miR-26a also correlated with invasion depth and lymph node metastasis (P<0.05), but not with sex, age, tumor size, or histological type (P>0.05). The area under the ROC curve of miR-26a was 0.828 (95％CI:0.776～0.881), with sensitivity of 73.3％and specificity of 81.0％, while the area under the ROC curve of miR-26b was 0.853 (95％CI:0. 801～0.906), with sensitivity of 68.1％and specificity of 99.2％. Conclusion:The expression of miR-26a/b significantly reduced in patients with gastric cancer, and its expression level correlated with the clinical stage, invasion depth, and lymph node metastasis. MiR-26a/b has potential diagnostic value for gastric cancer.

Rice is a major cereal crop for China. The development of the "three-line" hybrid rice system based on cytoplasmic male sterility in the 1970s (first-generation) and the "two-line" hybrid rice system based on photoperiod- and thermo-sensitive genic male-sterile lines (second-generation) in the 1980s has contributed significantly to rice yield increase and food security in China. Here we describe the development and implementation of the "third-generation" hybrid rice breeding system that is based on a transgenic approach to propagate and utilize stable recessive nuclear male sterile lines, and as such, the male sterile line and hybrid rice produced using such a system is non-transgenic. Such a system should overcome the intrinsic problems of the "first-generation" and "second-generation" hybrid rice systems and hold great promise to further boost production of hybrid rice and other crops.
China ; Oryza ; genetics ; growth & development ; Photoperiod ; Plant Breeding ; methods

Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been reported to be involved in each stage of cancer development, the role of miR-24 in GC has not been reported yet. In the present study, miR-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3'UTR of mRNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, miR-24 is a novel onco-miRNA that can be potential drug targets for future clinical use.
Animals ; Apoptosis ; genetics ; Apoptosis Regulatory Proteins ; deficiency ; genetics ; Base Sequence ; Bcl-2-Like Protein 11 ; Cell Line, Tumor ; Cell Movement ; genetics ; Cell Proliferation ; genetics ; Down-Regulation ; genetics ; Gene Silencing ; Male ; Membrane Proteins ; deficiency ; genetics ; Mice ; MicroRNAs ; genetics ; Proto-Oncogene Proteins ; deficiency ; genetics ; Rats ; Stomach Neoplasms ; genetics ; pathology