Objective To investigate the effect of laparoscopy-assisted partial small bowel resection combined with open tension-free hernioplasty on patients with strangulated inguinal hernia. Methods 98 patients with strangulated inguinal hernia from January 2013 to December 2015 in our hospital were enrolled in the study and divided into the minimally invasive group (n= 41, laparoscopy-assisted partial small bowel resection combined with open tension-free hernioplasty) and laparotomy group (n=57, open partial small bowel resection combined with Bassini repair) ac﹣cording to the operation mode. Preoperative baseline data, operation time, postoperative complications, postoperative hospital stay, survival status and recurrence rate were compared between two groups. Results There were no signifi﹣cant differences in preoperative baseline data between the two groups (P> 0.05). The incidence of postoperative chronic pain and recurrence in the minimally invasive group were significantly lower than that in laparotomy group (P< 0.05). There were no significant differences in operation time, incidence of incision infection, inguinal bruising or hematoma, postoperative hospital stay, perioperative mortality between the two groups (P>0.05). Conclusions For patients with strangulated inguinal hernia, laparoscopy-assisted partial small bowel resection combined with open tension-free hernioplasty could not only make full use of advantages of tension-free repair patch, but also avoid pol﹣lution of the bowel resection to patch, which can reduce the risk of infection and recurrence, it is worthy of clinical application.