Objective To compare the effect between mifepristone and medroxyprogesterone in the treatment of patients with perimenopausal dysfunctional uterine bleeding.Methods 90 patients with perimenopausal dysfunctional uterine bleeding were randomly divided into two groups after diagnostic curettage surgery,the control group (n =45 cases) and the observation group(n =45 cases).The patients in the control group were treated with medroxyprogesterone,while the patients in the treatment group were treated with mifepristone.The endometrial thickness,anemia and menstrual flow were analyzed after three months.Results The total efficient rates were 71.1％ in the control group and 88.9％ in the observation group.There was a significant difference between two groups (P ＜ 0.01).The endometrial thickness,anemia and menstrual flow were improved after treatment in both groups,which were more significantly improved in the treatment group (P ＜ 0.05).Conclusion The mifepristone is significantly better than medroxyprogesterone acetate tablets in the control perimenopausal dysfunctional uterine bleeding.

OBJECTIVE:To study the characteristics of the occurrence of ADR in our hospital so as to promote rational drug use in the clinic.METHODS:Information concerning clinical manifestation,patients'age,dosage forms,route of administration and the related drug variety of 162 cases of ADR reports collected in2004in our hospital were analyzed statistically.RESULTS:The main characteristics of the 162 ADR cases were like the following:the dosage forms of drugs administered was centralized,the patients turned out to be the older one,dosage of drugs were too much,course of treatment was longer,the percentage of allergic response was higher and etc.CONCLUSION:Medical worker should work cooperatively in the monitoring of ADR and promote rational drug use in the clinic.

Resveratrol is a natural phytoalexins.In vivo aud vitro experiments show that resveratrol could inhibit tumor metastasis by multiple approaches,such as influencing the expression level of matrix metalloproteinases and inhibitors,inhibiting tumor angiogenesis and interferencing signaling pathways,et al.

Objective To study the correlation of multiple factors with phlegm blood-stasis syndrome(PBSS) of coronary heart disease(CHD),and to explore the objective evidence for the clinical research.Methods A total of 135 cases was enrolled,which were divided into PBSS group(N=87) and non-PBSS group(N=48).Meanwhile,28 healthy volunteers served as the normal control.Five aspects including symptom scoring,hazard factor,basic laboratory examination,inflammatory factors and the result of coronarography were compared in the three groups.Results PBSS was the dominated syndrome of CHD.Symptom score in PBSS was higher.The analysis results of hazard factors of CHD showed that the body weight index,hypertension and the abnormal level of blood lipid were closely related with PBSS of CHD.The incidence of PBSS of CHD had a close relationship with the increased levels of total cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C) in blood lipid examination.Of the inflammatory factors,C-reactive protein(CRP),tumor necrosis factor ?(TNF-?),interleukin 6(IL-6),soluble CD40 ligand(SCD40L) and intercellular adhesion molecule 1(ICAM-1) levels were closely related with PBSS of CHD.The pathological changes of coronary artery of PBSS involved multiple vessels,and were severe.Conclusion Phlegm blood-stasis syndrome of coronary heart disease is relevant with multiple factors.

Objective Study the effect of chlorogenie acids(CHA)on insulin resistance in obese rats induced by high‐fat diet . Methods We induced the obese rat model by feeding high‐fat diet ,obese rat model were divided into 4 groups:model group ,piogli‐tazone group(4 .5 mg/kg) ,CHA large dose group and group ,and finally determinated the levels of glucose tolerance ,serum insulin , serum lipid profiles and others .Results CHA showed a higher anti‐obesity activity with lower rate of increase of obese rats′body weights ,reversingglucose intolerance induced by high‐fat diet ,ameliorating the hyperinsulinemia ,decreaseing the levels of TG and TC ,and increase liver glycogen and muscle glycogen level compared with other group which treated with high‐fat diet .And in‐creased HOMA‐ISI ,decreased HOMA‐IR .Conclusion CHA can ameliorate the symptoms of insulin resistance in obese rats ,which mechanism may be related with CHA can stimulate glucose uptake and utilization by peripheral tissues ,and decrease the the serum levels of FFA ,decrease oxygen stress ,prevent and cure the injury induced by lipid peroxidation .

Aconite roots are a common clinical poisonous herb in Chinese herb. It has the effect of restoring yang and rescuing collapse, supplementing fire and assisting yang, eliminating cold and relieving pain. It is used in the treatment of yang collapse and yang deficiency syndromes. It is called principle medicine of all medicines. Monks-hood polysaccharide is one of effective components in Aconite roots. The study found that monkshood polysaccharide has effects of immune regulation, antitumor, myocardial preservation, lipid lowering, etc.

OBJECTIVE:To understand the teaching effect of cooperative training model between colleges and hospitals,and provide reference for the teaching effect of clinical pharmacy. METHODS:Questionnaire survey was conducted on 87 clinical phar-macy students that joint trained by our hospital and Chongqing Medical University. The questionnaire included the students’opin-ions on teachers,teaching materials,teaching methods and suggestions for teaching improvement,all the questionnaires were col-lected and analyzed. RESULTS:There were totally 87 effective question naires with effective rate of 100%. 94.25% of students showed overall satisfaction in cooperative training model between colleges and hospitals,however,5 students thought distribution of the theoretical study time and the traine time still exist some problems;57.48% of students considered the textbook was not suit-able to use and they made recommendations;25.29% of students thought that clinicians responsible for teaching was not appropri-ate,the main reason was clinicians were not clear enough for drug teaching. CONCLUSIONS:Compared with traditional teaching model,the clinical pharmacist training model of cooperation between college and hospital has certain advantages,but some prob-lems still exist in the teachers,textbooks and curriculum arrangements,which need to be further improved.

Objective:To observe the influence of Xinfeng capsule(XFC) on pulmonary HRCT images and cytokines(TNF-?,IL-10) in blood serum adjuvant arthritis rats.Methods:60 rats were averagely divided into normal control group,model control group,methotrexate(MTX) treated group,tripterygium wilfordii polycoride tablet(TPT) treated group, XFC treated group,12 in each.Except for the rats of normal group,the others were intracutaneously injected with 0.1 ml of Freund’s complete adjuvant in the right hindlimb.After 19 days,different drugs were given to all rats. Pulmonary HRCT images were obtained and the blood samples were reserved for assaying cytokines.Results:In model control group ,the lungs’ outlines weren’t clear and the blood vessels expanded with the edges of them being obscure and unregular. There were high density images shaped as rope and slip in lungs of model control group rats and the pleura near the images were a little thickening. In MTX treated group, there were high density images shaped as slice along pulmonary veins. The veins of the blood vessels were obscure and the edges were unclear. In TPT treated group,there were multiple high density images shaped as tubercle and slice and the boundary were not clear. In XFC treated group, the lungs’ outlines were clear and the veins were well-distributed. High density images shaped as spot were found in part lungs. Compared with normal control group,tumor necrosis factor-?(TNF-?) in blood serum ascended obviously in model control group(P0.05).Conclusion:XFC eliminates swelling by down-regulating the levels of TNF-?, up-regulating the levels of IL-10, restraining the inflammatory reaction.In adittion,cytokines participated in forming pulmanory fibrofication.So the changes of pulmanory HRCT images were also improved at the same time.

OBJECTIVE:To compare clinical efficacy,safety and economy of urokinase and alteplase each combined with Enoxaparin sodium in the treatment of acute ST segment elevation myocardial infarction (STEMI). METHODS:80 STEMI pa-tients were randomly divided into control group and observation group,with 40 cases in each group. Both groups received Aspirin enteric-coated tablet for antiplatelet aggregation,and Clopidogrel hydrogen sulfate tablet for anticoagulation before thrombolysis. Control group were given urokinase 1 500 000 U added into 0.9% Sodium chloride injection 100 ml,ivgtt,within 30 min;given Enoxaparin sodium injection 7 500 U intramuscularly 12 h after thrombolysis,for 3-5 d. Observation group was given Enoxaparin sodium 60 U/kg,ivgtt,1 mg/ml Alteplase for injection 8 ml with intravenous push,other 42 ml ivgtt within 90 min;continued to receive Enoxaparin sodium with 12 U/(kg·h)micro-pump for 48 h,followed by Low molecular weight heparin calcium injection 5 000 U intramuscularly,bid,for consecutive 5 d. Clinical efficacy of 2 groups were observed,and thrombolytic recanalization situa-tion were observed 30,60,90 and 120 min after thrombolysis. ECG,cost-effectiveness and ADR were also observed. RESULTS:The effective rate of observation group(92.50%)was significantly higher than that of control group(85.00%). The rates of throm-bolytic recanalization in observation group 60,90 and 120 min after thrombolysis were significantly higher than in control group, with statistical significance(P<0.05). Q wave time,Qwave/Rwave and ST segment deviation of observation group after treatment were significantly lower than those of control group,with statistical significance(P<0.05). The total hospitalization cost of obser-vation group was significantly higher than that of control group,with statistical significance(P<0.05);there was no statistical sig-nificance in effective rate and the per unit cost of thrombolytic recanalization rate (P>0.05). The incidence of ventricular aneu-rysm,pericardial effusion,heart failure or cardiac shock,angina pectoris after infarction,severe arrhythmia,death and other as-pects in observation group were significantly lower than in control group,with statistical significance(P<0.05). CONCLUSIONS:Alteplase and enoxaparin thrombolysis therapy is better than urokinase and enoxaparin for STMEI in respects of clinical efficacy, and thrombolytic recanalization with less ADR and better safety;urokinase is cheaper and better than alteplase in cost-effectiveness ratio. Both of them can be used after careful consideration.

Objective To observe effects of Xinfeng capsule(XFC)on depressive mood and serum cortisol in patients with rheumatoid arthritis and study its mechanism.Methods 76 RA patients were randomly divided into two groups.The treatment group(n=40)was treated with XFC,and the control group(n=36)with Zhengqing Fengtongning.The targets included clinical effects,symptom and sign,integral of quality of life,self-rating depression scale(SDS)and serum cortisol.Results The effects of XFC were similar to that of Zhengqing Fengtongning in the total effective rate,improving symptoms and sign,active index,etc.XFC was superior to Zhengqing Fengtongning in improving SDS standard score,the symptoms of splenic asthenia and quality of life(P