1.Active surveillance for papillary thyroid microcarcinoma: considerations before making a decision
Chinese Journal of Endocrinology and Metabolism 2017;33(4):359-362
For rapidly increasing low-risk papillary thyroid micocarcinoma (PTMC), Japanese scholars have proposed that immediate surgery can be replaced by active surveillance, i.e. observation strategy. The new strategy has brought not only an important update to the management of PTMC, but also controversies from different perspectives. Here we would like to give a thorough review on the observation strategy for PTMC, including its development background, available clinical data, current recommendations/suggestions by guidelines/consensuses, common misunderstandings toward this topic, challenges, and prospective in the future.
2.Can we use vitamin D to prevent and treat COVID-19?
Chinese Journal of Endocrinology and Metabolism 2021;37(3):177-179
Multiple lines of evidence, including anti-inflammatory effects of vitamin D and the association of lower circulating vitamin D levels with the higher risk and worse outcomes in patients with coronavirus disease 2019 (COVID-19), suggested a potential role for vitamin D to prevent and treat COVID-19. However, existing results from quasi-experimental studies and clinical trials do not support routine use of high-dose vitamin D to curb COVID-19. It is still important to emphasize on correction of vitamin D deficiency before more results of ongoing clinical trials become available.
3.Post-operative follow-up and hormone treatment for thyroid cancer
Chinese Journal of Practical Internal Medicine 2003;0(01):-
Surgery is now still the first choice for treatment of thyroid cancer.Long-term post-operative follow-up and thyroid hormone treatment are of great importance in reducing recurrence,early detection of metastases or recurrence,and improving patients' quality of life.This article reviews the recent advancement in post-operative follow-up and hormone treatment in thyroid cancer patients.
4.Recent progress of study in pregnancy and thyroid cancer
Chinese Journal of Endocrinology and Metabolism 2014;30(12):1132-1134
Thyroid cancer accounts for the most common endocrine malignancies in women during childbearing age.Many questions remain to be answered regarding the association between thyroid cancer and pregnancy.This review will discuss both the effects of pregnancy on thyroid cancer and vice versa.Recommendations on how to manage thyroid cancer in pregnancy will also be cited from a Chinese academic guideline as listed at the end of this review.
5.Utility of the BRAFT1799Amutation in papillary thyroid cancer
Chinese Journal of Endocrinology and Metabolism 2011;27(6):525-528
Significant progress has been made toward understanding the tumorigenic role and clinical significance of the T1799A B-type Raf kinase(BRAF)mutation in papillary thyroid cancer(PTC). With these advances, it has become clearer that BRAF mutation will likely have significant impact on the clinical management.
6.The evolving field of tyrosine kinase inhibitors in the treatment of thyroid carcinoma
Chinese Journal of Endocrinology and Metabolism 2012;28(10):798-801
The outstanding progress in the molecular basis of thyroid carcinoma has offered a tool for the development of new drugs,mainly tyrosine kinase inhibitors (TKIs).A number of TKIs are now being applied to the treatment of thyroid carcinomas.Recent clinical trials of TKIs in patients with advanced thyroid cancer have shown some promising preliminary results.This review summarizes the most relevant achievements in the field and the challenges we are facing.
8.Immediate effects of three different regimens in advanced colorectal cancers
Haixia QIN ; Kejun NAN ; Guan YANG
China Oncology 2001;0(03):-
0.05).Conclusions:There was no difference in terms of both effect and toxicity among the three regimens. All of them were effective and could be well tolerated by advanced colorectal cancer patients.
9.The study of Th_1/Th_2 bias in Hashimoto thyroiditis
Jinyuan MAO ; Chenling FAN ; Haixia GUAN
Chinese Journal of Practical Internal Medicine 2002;0(08):-
Objective To explore the trend of Th_1/Th_2 bias in Hashimoto thyroiditis(HT)and their effects on the pathogenesis of HT.Methods The proportion and mean fluorescence intensity(MFI)of CCR5 and CD30 were examined on peripheral T lymphocytes by flow cytometry in patients with Hashimoto thyroiditis(HT)(n=21)and healthy controls(n=45).Results The proportion of both CD4~+CCR5~+and CD~+4 CD30~+ cells were significantly increased in HT group(P
10.Thyroid diseases in adults aged over 60 years in the northern countryside.
Haixia GUAN ; Zhongyan SHAN ; Xiaohui YU
Chinese Journal of Practical Internal Medicine 2001;0(10):-
Objective To assess the prevalence,development and prognosis of thyroid disorders in adult healthy subjects aged over 60 years.Methods We performed a cross-sectional study in 1999 and a 5-year follow-up study in 2004.A total of 102 men and 147 women aged 60 to 88 years from rural communities in north China were studied.Serum thyrotropin(TSH),thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)were determined by an immunochemiluminometry assay in all participants.Free triiodothyronine(FT_3)and free thyroxine(FT_4)were determined in subjects with abnormal TSH results.Results We dropped the reference range for TSH into 0.28~4.75 mU/L.The prevalence of thyroid dysfunction,positive TPOAb and TgAb was 10.84%,12.85%and 11.65%,respectively.six newly diagnosed patients were found in the follow-up study,3 cases(all women)with hypothyroidism and 3(all men)with hyperthyroidism.Conclusion The high prevalence of thyroid dysfunction in the elderly indicates screening is necessary.Most elderly patients with subclinical dysfunction can recover spontaneously.The strategy should be focused on whether we monitor these patients.