Neonatal bacterial meningitis may lead to severe neurological sequelaes,with a high mortality rate.It shows different etiology characteristics in different regions and different days of age.The lack of specific clinical manifestations of the disease,easily lead to delays in diagnosis and treatment.Diagnosis needs to realize cerebrospinal fluid (CSF) culture and biochemical parameters by lumbar puncture,however,the rate of positive in CSF culture is extremely low,and the sensitivity in biochemical parameters in the early days and after treatment with antibiotics may be decreased.The reverse transcription-PCR technique may improve the early diagnosis of specificity and sensitivity,but which is expensive and restricted by technical conditions,therefore,clinicians should be alert to the suspicious children and to check in time even repeated lumbar puncture.The third generation of cephalosporins antibiotics are the choices for gram-negative bacilli,gram-positive coccus preferred vancomycin,hormone application is still not advocate.Because of greater incidence of neurological complications of bacterial meningitis in neonates,head imaging examination timely in treatment process is an important means of assessing prognosis.

Osteoporosis （OP）， a common systemic skeletal disease in the elderly， is characterised by bone loss and bone microstructural degeneration. Its clinical manifestations include increased bone fragility and bone pain. Furthermore， OP increases the risk of fracture due to the high bone fragility， which leads to lifelong disability or death， imposing a heavy economic and psychological burden on the patients and their families. The pathogenesis of OP is extremely complex and associated with a variety of factors such as proliferation and differentiation of osteoblasts， impairment of osteoclast activity and function， and abnormalities in autophagy activation. Recent studies have found that mammalian target of rapamycin （mTOR） signaing pathway is involved in the regulation of bone homeostasis， which can promote bone formation and improve bone metabolism and bone microstructure by regulating osteoblast proliferation and differentiation and osteoclast function and activating cellular autophagy， thus playing a crucial role in the prevention and treatment of OP. The prevention and treatment of OP with Chinese medicine has a long history， clear efficacy， multiple targets of action， low adverse effects， and wide medicine sources. Therefore， this paper briefly describes the role of mTOR signaling pathway in the development of OP by reviewing the latest research reports and summarizes in detail the latest research results on the treatment of OP with Chinese medicine extracts and prescriptions via the mTOR signaling pathway. This review aims to provide a basis for the in-depth research on the relationship between mTOR signaling pathway and OP and the clinical application of traditional Chinese medicine in the prevention and treatment of OP.