Objective:To understand the situation of drug expense dishonour to the patients participated in health insurance new rural cooperative medical system ( NCMS) in our hospital, analyze the dishonour reasons and find countermeasures. Methods:The da-ta of drug expense dishonour to the patients participated in health insurance NCMS were collected in our hospital during October 2014 and October 2015, the reasons for the dishonour were analyzed, and countermeasures were proposed in order to reduce the dishonour under the policy of health insurance NCMS. Results:The most common reason of drug expense dishonour was the violation of restricted medication rules in the policy followed by the irrational use of Chinese medicines and antimicrobial drugs. Hospital should look for countermeasures according to the reasons for the dishonour in order to promote the implementation of the new rural cooperative medical policy and strengthen the rational and regular drug use under the policy of health insurance NCMS. Conclusion: The most important reason for drug expense dishonour was the incompletely implementation of the policy of health insurance NCMS, and the violation of drug use exists in our hospital. Pharmacy department should supervise drug use, focus on promoting the policy of health insurance NC-MS, implement forward position, participate in medication development and promote rational drug use.