1.Intramedullary nail or anatomical plate internal fixation for closed reduction of femoral shaft fracture: comparison of fracture stability
Chinese Journal of Tissue Engineering Research 2015;19(17):2724-2729
BACKGROUND:Closed reduction of femoral shaft fracture is a common orthopedic fracture type,and can be treated conservatively,but comminuted fracture and serious conditions should be treated by surgery.Intramedulary nail and anatomical plate are commonly used for internal fixation,the choice of the two materials for the femoral fixation remains controversial.OBJECTIVE:To compare and analyze the clinical prognosis and fracture stability in closed reduction of femoral shaft fractures with intramedulary nail or anatomical bone plates.METHODS:From January 2011 to December 2013,86 patients with femoral shaft fracture recruited from Jiangdu People's Hospital of Yangzhou were involved in the retrospective study.Al patients were divided into two groups,receiving intramedulary nail and anatomical bone plates,respectively.Clinical prognosis,fracture stability and adverse events in the two groups were compared.RESULTS AND CONCLUSION:The intraoperative blood loss and postoperation drainage volume in the intramedulary nail group were significantly lower,while the operation time and fracture healing time were significantly shorter than the anatomical bone plates group (P<0.05).The excelent and good rate was higher in the two groups,and there was no significant difference between the two groups,although the rate in intramedulary nail group was higher than anatomical bone plates group (P>0.05).The adverse reactions inintramedulary nail group were significantly less than anatomical bone plates group (9%,35%,P<0.05).Compared with the intramedulary nail group,more cases in anatomical bone plates group appeared poor fixation and fixator rupture,the incidence of complications was higher,and postoperative stability was poorer.Experimental findings indicate that,both intramedulary nail and anatomical bone plates can achieve good outcomes in the treatment of closed reduction of femoral shaft fractures,but the intramedulary nailing causes fewer trauma,lower incidence of adverse events,and better compatibility and stable,it is worthy of clinical application.
2.A study of sleep architecture and cognitive functions in dementia with Lewy bodies
Quan PENG ; Yuping NING ; Haishan SHI ; Dong ZHENG
Journal of Chinese Physician 2015;17(9):1351-1355
Objective To investigate the sleep architecture in dementia with Lewy bodies (DLB),and study the sleep architecture and cognitive functions in DLB.Methods We described polysomnography (PSG) findings in 34 consecutive subjects diagnosed with DLB.All the patients underwent Mini-Mental State Examination (MMSE),Montreal Cognitive Assessment (MoCA),Clinical Dementia Rating (CDR) to quantify cognitive functions.Results (1)Sleep architecture analysis:DLB group compared to normal control group,the sleep period time (SPT) was reduced (P < 0.05),total sleep time (TST) and sleep efficiency (SE) were decreased,total wake time (TWT) and wake after sleep onset (WASO) were increased,1 non-rapid eye movement (NREM) sleep (TS1),2NREM sleep (TS2),total NREM sleep (TNREMS),and REM sleep (TREMS) time were significantly decreased (P <0.01).(2)The DLB patients were divided into groups based on MMSE,MoCA,qnd CDR scores,the sleep architecture of each group was no significant difference (P > 0.05).Conclusions Patients with DLB exists sleep architecture disorder.The cognitive functions and sleep architecture changes in patients with DLB have no obvious correlation.It is different from other degenerative dementia.
3.Clinical analysis and management of complications of breast augmentation with injected polyacrylamde hydrogel
Haishan SHI ; Chuan CAO ; Liang CHEN ; Xiaoge LI ; Shirong LI
Journal of Regional Anatomy and Operative Surgery 2015;(3):263-266
Objective To discuss the clinical manifestation and treatment of the complications caused by injected polyacrylamde hydro-gel( PAAG) for breast augmentation. Methods This retrospective research was performed among 212 patients who undergoing breast aug-mentation with injected polyacrylamde hydrogel. The clinical manifestation and treatment outcome of the complications were analyzed and summarized,which is aim to search an effective treatment method. Results For the 212 patients,the main complications were breast multi-ple indurations (131 cases),fever (9 cases),infection (14 cases),breast pain (65 cases),PAAG displacement (28 cases) and secondary deformity or asymmetry (25 cases). 152 cases experienced one clinical symptom,the rest patients simultaneously undergone no less than two clinical symptoms. Patients were received open operation with periareolar incision ( surgery group) or vacuum absorption by needle ( aspira-tion group) for dislodging PAAG. No significant difference was found in wound healing,breast shape satisfaction and pain anesis between the two groups. Whilethe surgery group was better than the aspiration group in efficiency for taking out PAAG and the incidence of reoperation, with statistical significance. Conclusion A plenty of complications occurred after breast augmentation with injected polyacrylamde hydrogel, the method of open operation with periareolar incision is a better way for eliminating PAAG and treating the complications.
4.Interaction of SNP in non-coding region between estrogen receptor alpha gene and brain-derived neurotrophic factor (BDNF) gene in late-onset Alzheimer's disease in southern Chinese Han population
Yuping NING ; Le HOU ; Muni TANG ; Yan TAN ; Kangguang LIN ; Haishan SHI
Chinese Journal of Nervous and Mental Diseases 2009;35(12):717-721
Objective To study the interaction of BDNF gene C270T polymorphism and estrogen receptor alpha (ERα)gene Xba Ⅰ loci and Pvu Ⅱ loci polymorphism in late-onset Alzheimer's disease(LOAD)pathogenesis in southern Chinese Han population.Methods BNDF gene C270T locus,ERα gene Xba Ⅰ site and Pvu Ⅱ site polymorphisms were examined in 203 LOAD patients and normal controls using PCR-RFLP technique.Results There was an interaction be-tween BDNF gene and ERα gene,and BDNF gene C270T locus CC genotype and the ERa gene Xba Ⅰ locus xx genotype increased the LOAD incidance risk(OR=2.38,95%CI:1.02~5.53).Conclusions BDNF gene and ERα gene are in-teracted each other in the pathogenesis of LOAD.Patients carrying both BDNF gene C270T locus CC genotype and the ERα gene Xba Ⅰ locus xx genotypes might have an increased risk for LOAD.
5.The study on the relationship between the 1h-proton magnetic resonance spectroscopy and cognitive im-pairment in patients with general paresis of the insane
Haishan SHI ; Xiaomei ZHONG ; Le HOU ; Xinni LUO ; Xinru CHEN ; Sha LIU ; Dong ZHENG ; Yuping NING
Chinese Journal of Nervous and Mental Diseases 2016;42(7):406-409
Objective We aimed to use 1H-MRS to characterize metabolite concentrations in the bilateral hippo?campus in GPI patient. Methods Metabolite ratios in the bilateral hippocampus were compared between patients with GPI (n=52) and Normal Control (NC) (n=38). Clinical neurological tests were measured in all subjects and were correlat?ed to the metabolite concentrations. Results The GPI patients showed significantly lower concentrations of N-acetylas?partate(NAA)/creatine(Cr) ratios in the bilateral hippocampus region compared to the NC subjects. There was significant?ly difference in the NAA/Cr ratios between the mild GPI dementia and the severe GPI dementia groups on the left hippo?campus region. We found that the NAA/Cr ratios concentrations were positively correlated with Mini Mental state Exami?nation (MMSE) and Montreal Cognitive Assessment scale (MoCA) scores in the left hippocampus region and the mI/Cr ra?tios concentrations were positively correlated. Conclusions GPI Patients have neuronal dysfunction in the bilateral hippo?campus. The severity of cognitive impairments is associated with the severity of the damage in the left side.
6.Comparison of therapeutic effect between skin flap-extension auricular reconstruction and improved Brent au-ricular reconstruction
Wei LYU ; Julong WU ; Liang WANG ; Fan WANG ; Haishan SHI ; Shirong LI
Journal of Regional Anatomy and Operative Surgery 2016;25(3):188-190
Objective To compare the rate of postoperative complications and satisfaction between skin flap -extension auricular recon-struction ( hereinafter flap-extension ) and improved Brent auricular reconstruction ( hereinafter improved Brent ) .Methods From October 2009 to October 2014, totally 199 patients who have been diagnosed as congenital microtia and received auricular reconstruction were divided into two groups.Group A (159 patients) received flap-extension and Group B (40 patients) received improved Brent.The medical records, pre-and post-surgery photos of all patients were analyzed and satisfaction of patients was collected by the telephone follow -up.Results Pa-tients in both of the two groups were satisfied with their therapies .There were 47 cases of complications in Group A (29.6%, 47/159) and 5 cases of complications in Group B (12.5%, 5/40).The postoperative complications were significantly different between the two groups (P<0.05).Conclusion There was no difference in patients ’ satisfaction between the two methods ,but the postoperative complications of improved Brent were much lower .
7.Application of cosmetic suture technique for reparation and reconstruction in facial emergency surgery
Xiaoge LI ; Hongxia WANG ; Shupeng HUANG ; Le LI ; Haishan SHI ; Yi JI ; Liang CHEN
Journal of Regional Anatomy and Operative Surgery 2015;(3):285-286,287
Objective To investigate the clinical effect of cosmetic suture technique applied in organs of facial emergency surgery. Methods There were 25 patients who were admitted in our hospital from August 2009 to December 2013. After anatomical reduction and functional restoration, they were given surgery with cosmetic suture technique on the base of debridement. Results All of the patients a-chieved good surgical result, the satisfaction is 100%. After the first stage of operation, 23 patients of them were of no obvious scar and good function recovery. The other 2 patiens also got good effects after secondary surgery. Conclusion Cosmetic suture technique pay attaintion to anatomical and functional restoration. It is of equisite technique, slight injury, less scar after operation and it can maximumly get close to the normal tissue structures and achieve the objective of beauty.
8. Comparison of the middle-term follow-up results between anterior decompression with fusion and posterior open-door laminoplasty for treatment of multi-level cervical spondylotic myelopathy
Haishan GUAN ; Chenggang LI ; Jie SHI ; Jianghua TIAN ; Laichun HAN
Chinese Journal of Orthopaedics 2019;39(17):1044-1052
Objective:
To compare the medium-term clinical and radiologic outcomes between anterior decompression with fusion (ADF) and posterior open-door laminoplasty (LAMP) in the treatment of multi-level cervical spondylotic myelopathy (MCSM).
Methods:
Data of 121 patients meeting to inclusion criteria from October 2011 to February 2016 were retrospectively analyzed. All the patients were treated with ADF (ADF group,
9.The study of plasma levels of sCD40 and sCD40L in Alzheimer’s disease and mild cognitive impairment
Ling LI ; Xiaomei ZHONG ; Haishan SHI ; Le HOU ; Xinni LUO ; Yanhua WANG ; Guoyan HU ; Xinru CHEN ; Wenru ZHANG ; Ben CHEN ; Qi PENG ; Yuping NING
Chinese Journal of Nervous and Mental Diseases 2016;42(8):460-464
Objective To explore the plasma levels of soluble CD40 (sCD40) and soluble CD40 ligand (sCD40L) in the patients with Alzheimer’s disease (AD) and those with amnestic mild cognitive impairment (aMCI). Methods The levels of plasma sCD40 and sCD40L were measured in 20 patients with AD, 35 patients with aMCI, and 32 cognitively normal controls (NC) using commercially available ELISAs. The cognitive function of AD and aMCI patients was mea?sured by mini-mental state examination (MMSE). Results There were significant differences in plasma sCD40 among AD, aMCI and NC groups (P<0.05) as the medians (the upper and lower quartiles) of plasma levels were 123.3 (97.4, 149.5) pg/mL, 102.9 (63.6, 124.0) pg/mL and 70.66 (51.0, 90.8) pg/mL, respectively. There were significant differences in plasma sCD40L among AD, aMCI and NC groups (P<0.05) as plasma levels were 537.0 (316.0, 1134.0) pg/mL, 316.0 (190.0,546.0) pg/mL and 167.0 (107.5,478.0) pg/mL. A negative correlation between the plasma concentrations of sCD40L and the MMSE scores was found in aMCI patients (r=-0.736, P<0.001). Conclusions There are relevant chang?es of plasma sCD40 and sCD40L levels in patients with AD and aMCI. The present results suggest that plasma levels of sCD40 and sCD40L may be appropriate biomarkers for AD patients and indicate that CD40-CD40L signaling may be in?volved in AD pathophysiology.
10.The effect of reduction and in situ fusion on postoperative imaging parameters of degenerative lumbar spondylolisthesis
Haoran SHI ; Tao LIU ; Yueyong WANG ; Haosheng ZHOU ; Zhuangzhi DING ; Haishan GUAN
Chinese Journal of Orthopaedics 2023;43(15):999-1006
Objective:To compare the efficacy of reduction and in situ intervertebral fusion fixation in the treatment of degenerative lumbar spondylolisthesis.Methods:A total of 182 patients (92 males and 90 females) with L 4 degenerative lumbar spondylolisthesis of Meyerding's classification of grade I and grade II, aged (62.6±6.8) years (range, 57-73 years), who underwent posterior L 4, 5 internal fixation and interbody fusion in the Department of Spinal Surgery, the Second Hospital of Shanxi Medical University, were retrospectively analyzed from January 2019 to December 2022. There were 105 cases of I-degree spondylolisthesis and 77 cases of II-degree spondylolisthesis. According to the operation method, the patients were divided into reduction intervertebral fusion fixation (reduction group) and in situ intervertebral fusion fixation group (in situ group). Imaging parameters such as lumber lordosis (LL), pelvic incidence (PI)-LL, L 3, 4 intervertebral space heights, fusion segment angle, and sagittal vertical axis (SVA) were measured on the pre- and post-surgical lumbar spine lateral radiographs. The visual analogue scale (VAS) and Oswestry Disability Index (ODI) of low back pain were recorded before and after surgery. The differences in clinical and imaging parameters were compared between reduction and in situ fusion group. Results:All 182 patients successfully completed the surgery and were followed up for 12.0±2.4 months (range, 9-15 months). The LL of the reduction group before surgery, immediately after surgery, and at the last follow-up were 46.9°±7.1°, 57.2°±5.9°, 55.6°±5.5°, respectively, with statistically significant differences ( F=87.61, P<0.001), with immediate and final follow-up being smaller than those in the in situ fixation group. The LL of the in situ fixation group before surgery, immediately after surgery, and at the last follow-up were 47.8°±7.2°, 50.5°±7.0°, and 48.7°± 6.4°, respectively, with no statistically significant difference ( F=2.83, P=0.062). The immediate and final follow-up of LL in the reduction group was lower than those in the in situ fixation group ( P<0.05). The fusion segment angles of the reduction group before surgery, immediately after surgery, and at the last follow-up were 14.2°±5.1°, 23.2°±4.7°, 23.2°±4.7°, respectively, with statistically significant differences ( F=152.87, P<0.001), with immediate and final follow-up after surgery being greater than before surgery. The fusion segment angles of the in situ fixation group before surgery, immediately after surgery, and at the last follow-up were 15.4°±5.9°, 18.2°±5.5°, and 17.4°±5.1°, respectively, with statistically significant differences ( F=4.69, P=0.009), with immediate and final follow-up being greater than before surgery. The fusion segment angulation in the reduction group was greater than that in the in situ fixation group at both the immediate and final follow-up ( P<0.05). The SVA of the reduction group before surgery, immediately after surgery, and at the last follow-up were 16.9±18.2 mm, 9.5±12.0 mm, and 8.7±11.3 mm, respectively, with statistically significant differences ( F=11.32, P<0.001), with immediate and final follow-up being smaller than before surgery. The SVA of immediately after surgery and at the last follow-up were both smaller than before surgery. The SVA of the in situ fixation group before surgery, immediately after surgery, and at the last follow-up were 16.4±17.2 mm, 14.3±15.5 mm, and 13.8±15.0 mm, respectively, with no statistically significant difference ( F=0.57, P=0.576). The SVA of the reduction group at immediate and final follow-up was lower than that of the in situ fixation group ( P<0.05). Conclusion:Both reduction and in situ intervertebral fusion fixation can effectively relieve the clinical symptoms of patients. Fusion fixation after reduction can improve the angulation of fusion segments to form segmental kyphosis, which is more conducive to improving SVA.