Objective To investigate the constitution factors for metabolic syndrome(MS). Methods 271 MS cases and 271 non-MS controls were selected. They were assessed according to the diagnosis standard of constitution of TCM. Results Multiple logistic regression analysis revealed that phlegm-dampness constitution and dampness-heat constitution were dangerous factors for MS, normal constitution was protective factor for MS (P<0.05). Conclusion Research on constitution play a role in investigating pathogenesis of MS.