A study was conducted to investigate the effectiveness of freeze-dried bovine pericardium (FDBP) as a biomaterial in diaphragmatic herniorrhapy in dogs. Eight adult dogs were randomly selected and divided into two equal groups. In FDBP group, a diaphragmatic defect was induced and repaired with an identical size of FDBP. In the control group, a diaphragmatic wall was incised at three-side border creating a flap and sutured. Grossly, only mild intrathoracic adhesion was observed for most of the animals, and no herniation occured. Microscopically, the biomaterial incorporated into the host's tissue by ingrowth of young muscle fiber and massive new blood vessel formation in between the fibrous tissue.
*Biological Dressings ; Biomechanics ; Diaphragm/pathology ; Diaphragm/surgery ; Freeze Drying ; Hernia, Diaphragmatic/pathology ; Hernia, Diaphragmatic/*surgery ; *Materials Testing ; Pericardium ; *Prostheses and Implants