1.Effects of Electrical Stimulation on Dysphagia after Stroke
Xianni WANG ; Hong LIN ; Haini QI ; Yifang ZHU ; Ping XU
Chinese Journal of Rehabilitation Theory and Practice 2008;14(3):222-223
Objective To investigate the effects of electrical stimulation on dysphagia after stroke.Methods 40 patients with dysphagia after stroke were divided into control group and research group randomly.Both groups were treated with rehabilitation training and medicine.Research group was managed with electrical stimulation in addition.They were assessed with the classification of dysphagia.Results Dysphagia was reduced in both groups,but was better in the research group than in the control group(P<0.05).Conclusion Electrical stimulation can improve the recovery of deglutition.
2.Study on Extraction Technique for Xiangjiang Granula Essential Oil
Haini LI ; Siwang WANG ; Jianbo WANG ; Ying CHANG ; Jianbo TU ; Zhihua QI
China Pharmacy 2001;0(12):-
OBJECTIVE: To study the optimum supercritical- fluid extraction technique for Xiangjiang Granula essential oil. METHODS: The orthogonal test was adopted to optimize the extraction process using the content of Ligustilide and the yield rate of essential oil as indicators, and 95% ethanol as co- solvents. The content of Ligustilide was determined by HPLC, using Phenomenex Luna C18( 250nm? 4. 6nm, 5? m) as column and methanol- 0. 5% glacial acetic acid( 30∶ 70) as mobile phase, with the detection wavelength set at 280 nm. RESULTS: The optimal extraction conditions were: temperature at 50℃ , pressure at 45MPa, extraction time for 3h, and 95% ethanol as co- solvents. The Ligustilide had a good linearty relationship between 5. 1~ 25. 5? g? mL- 1( r=0. 999 8) . CONCLUSIONS: This technique is easy, convenient and workable, and can provide theoretical support for production.
3.The biological effects of multi-electrode radiofrequency ablation on normal rabbit lungs.
Weiqiang ZHANG ; Qingshu CHENG ; Lianjun MA ; Yunjie WANG ; Kun LIU ; Mingxiang DU ; Haini QI
Chinese Journal of Lung Cancer 2002;5(6):444-446
BACKGROUNDTo study the biological effects of multi-electrode radiofrequency ablation on pulmonary tissues of rabbits.
METHODSUnder the guidance of computer tomograph, electrodes were inserted into right lungs of New Zealand white rabbits and radiofrequency was performed. The biological effects were observed through CT image and microscopy.
RESULTSCoagulative necrosis was found immediately in ablation area after the procedure. On the 7th postradiofrequency ablation day, fibrous tissues appeared in the necrotic lesions. On the 30th postradiofrequency ablation day, bronchial and alveolar epithelium began to proliferate. Within 60 to 90 days after treatments, the necrotic lesions were almost replaced by normal pulmonary tissues. In group with electrodes into the right hilum, time for treating and initial impedance were significantly different from those with electrodes into the peripheral sites of the right-lower lobes (P < 0.01, P < 0.01).
CONCLUSIONSMulti-electrode radiofrequency ablation can be safely and effectivly performed in pulmonary tissue and cause coagulative necrosis within a certain extent.
4.The effect of radio-frequency ablation in the treatment of the VX2 tumor in rabbit lung.
Lianjun MA ; Qingshu CHENG ; Kun LIU ; Yunjie WANG ; Yaocheng WANG ; Daoxi WANG ; Weiqiang ZHANG ; Zhengyuan ZHAO ; Haini QI ; Mingxiang DU
Chinese Journal of Lung Cancer 2002;5(2):115-118
BACKGROUNDTo observe the CT appearance and pathological changes of VX2 tumor in rabbit lung after radio-frequency ablation.
METHODSAfter VX2 tumor tissue suspension was injected into the lungs, the transplanted lung cancer models were established in 36 New Zealand white rabbits. Twenty-eight rabbits were treated with radio-frequency ablation, and another 8 rabbits without any treatment as control. The CT appearances and pathological changes were observed in different time intervals after the treatment in 14 rabbits out of experimental group. The survival periods of the rabbits were recorded in the rest 14 rabbits of experimental group and the control group respectively.
RESULTSCoagulative necrosis and cell apoptosis appeared in the tumor tissues after the ablation, and inflammatory cells were found in the lung tissues around the areas of ablation. Wadding shadows appeared in CT images after the treatment and disappeared with the inflammation vanished, but the tumor shadows ceased to increase. In the experimental group, tumor tissues were almost necrosed in the target areas of 21 rabbits, however, peripheral residual nests of histologically viable tumor were found in the target areas of the other 7 rabbits. The survival periods of rabbits in the experimental group and the control group were 38 days±3.4 days days and 26 days±2.8 days respectively (P < 0.05).
CONCLUSIONSRadio-frequency ablation may be an effective method in the treatment of lung cancer.